Physicochemical properties of lipoproteins assessed by nuclear magnetic resonance as a predictor of premature cardiovascular disease. Presarv-sea study
Fernández-Cidón, Bárbara (Institut d'Investigació Biomèdica de Bellvitge)
Candás-Estébanez, Beatriz (Hospital Universitari de Bellvitge)
Gil-Serret, Miriam (Biosfer Teslab)
Amigó, Núria (Universitat Rovira i Virgili)
Corbella, Emili (Institut d'Investigació Biomèdica de Bellvitge)
Rodríguez-Sánchez, M. Ángeles (Institut d'Investigació Biomèdica de Bellvitge)
Padró i Miquel, Ariadna (Institut d'Investigació Biomèdica de Bellvitge)
Brotons, Carlos (Institut d'Investigació Biomèdica Sant Pau)
Hernández-Mijares, Antonio (Hospital Universitari Doctor Peset (València))
Calmarza, Pilar (Hospital Universitario Miguel Servet (Saragossa))
Jarauta, Estíbaliz (Hospital Universitario Miguel Servet (Saragossa))
Brea-Hernando, Ángel (Hospital General San Pedro (Logronyo, La Rioja))
Mauri Pont, Marta (Consorci Sanitari de Terrassa. Hospital de Terrassa (Terrassa, Catalunya))
Guijarro, Carlos (Hospital Universitario Fundación Alcorcón)
Vila, Àlex (Hospital de Figueres)
Valdivielso, Pedro (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Corbella, Xavier (Hospital Universitari de Bellvitge)
Pintó, Xavier (Hospital Universitari de Bellvitge)

Date:	2021
Abstract:	Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipopro-teins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL parti-cles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.
Grants:	Instituto de Salud Carlos III PI16/01094 Instituto de Salud Carlos III PI19/01032
Note:	Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	NMR analysis of lipoproteins ; Lipid profile ; Premature cardiovascular disease ; Residual cardiovascular risk ; Small dense LDL ; Lipoprotein particle number ; Lipoprotein precipitation
Published in:	Journal of clinical medicine, Vol. 10 Núm. 7 (january 2021) , p. 1379, ISSN 2077-0383

DOI: 10.3390/jcm10071379
PMID: 33805580

10 p, 459.1 KB

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