Comparative genomics reveals the hybrid origin of a macaque group
Zhang, Baolin (Chinese Academy of Sciences)
Chen, Wu (Guangzhou Zoo and Guangzhou Wildlife Research Center)
Wang, Zefu (Sichuan University)
Pang, Wey (Chinese Academy of Sciences)
Luo, Meng-Ting (Chinese Academy of Sciences)
Wang, Sheng (Chinese Academy of Sciences)
Shao, Yong (Chinese Academy of Sciences)
He, Wen-Qiang (Chinese Academy of Sciences)
Deng, Yuan (University of Copenhagen)
Zhou, Long (Zhejiang University School of Medicine)
Chen, Jiawei (BGI-Shenzhen)
Yang, Min-Min (Chinese Academy of Sciences)
Wu, Yajiang (Guangzhou Zoo and Guangzhou Wildlife Research Center)
Wang, Lu (Northwest University)
Fernández-Bellon, Hugo (Zoo de Barcelona)
Molloy, Sandra (Dublin Zoo)
Meunier, Hélène (Université de Strasbourg)
Wanert, Fanélie (Université de Strasbourg)
Kuderna, Lukas (Illumina Inc)
Marques-Bonet, Tomas 1975- (Institut Català de Paleontologia Miquel Crusafont)
Roos, Christian (German Primate Center)
Qi, Xiao-Guang (Northwest University)
Li, Ming (Chinese Academy of Sciences)
Liu, Zhijin (Capital Normal University)
Schierup, Mikkel Heide (Aarhus University)
Cooper, David N. (Cardiff University)
Liu, Jianquan (Sichuan University)
Zheng, Yong-Tang (Chinese Academy of Sciences)
Zhang, Guojie (Zhejiang University Medical Cente)
Wu, Dong-Dong (Chinese Academy of Sciences)

Data:	2023
Resum:	Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque species and show that the fascicularis group originated from an ancient hybridization between the sinica and silenus groups ~3. 45 to 3. 56 million years ago. The X chromosomes and low-recombination regions exhibited equal contributions from each parental lineage, suggesting that they were less affected by subsequent backcrossing and hence could have played an important role in maintaining hybrid integrity. We identified many reproduction-associated genes that could have contributed to the development of the mixed sexual phenotypes characteristic of the fascicularis group. The phylogeny within the silenus group was also resolved, and functional experimentation confirmed that all extant Western silenus species are susceptible to HIV-1 infection. Our study provides novel insights into macaque evolution and reveals a hybrid speciation event that has occurred only very rarely in primates.
Ajuts:	European Commission 864203 Agencia Estatal de Investigación BFU2017-86471-P
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Science advances, Vol. 9, Issue 22 (June 2023) , art. eadd3580, ISSN 2375-2548

DOI: 10.1126/sciadv.add3580
PMID: 37262187

14 p, 1.4 MB

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