| Abstract: |
Background and aim: COVID-19 patients with severe heart or respiratory failure are potential candidates for extracorporeal membrane oxygenation (ECMO). Indications and management of these patients are unclear. Our aim is to describe the results of a prospective registry of COVID-19 patients treated with ECMO. Methods: An anonymous prospective registry of COVID-19 patients treated with veno-arterial (V-A) or veno-venous (V-V) ECMO was created on march 2020. Clinical, analytical and respiratory preimplantation variables, implantation data and post-implantation course data were recorded. The primary endpoint was all cause in-hospital mortality. Secondary events were functional recovery and the combined endpoint of mortality and functional recovery in patients followed at least 3 months after discharge. Results: Three hundred and sixty-six patients from 25 hospitals were analyzed, 347 V-V ECMO and 18 V-A ECMO patients (mean age 52. 7 and 49. 5 years respectively). Patients with V-V ECMO were more obese, had less frequently organ damage other than respiratory failure and needed less inotropic support; Thirty three percent of V-A ECMO and 34. 9% of V-A ECMO were discharged (P = NS). Hospital mortality was non-significantly different, 56. 2% versus 50. 9% respectively, mainly during ECMO therapy and mostly due to multiorgan failure. Other 51 patients (14%) remained admitted. Mean follow-up was 196 ± 101. 7 days (95%CI: 170. 8-221. 6). After logistic regression, body weight (OR 0. 967, 95%CI: 0. 95-0. 99, P = 0. 004) and ECMO implantation in the own centre (OR 0. 48, 95%CI: 0. 27-0. 88, P = 0. 018) were protective for hospital mortality. Age (OR 1. 063, 95%CI: 1. 005-1. 12, P = 0. 032), arterial hypertension (3. 593, 95%CI: 1. 06-12. 19, P = 0. 04) and global (2. 44, 95%CI: 0. 27-0. 88, P = 0. 019), digestive (OR 4,23, 95%CI: 1. 27-14. 07, P = 0. 019) and neurological (OR 4. 66, 95%CI: 1. 39-15. 62, P = 0. 013) complications during ECMO therapy were independent predictors of primary endpoint occurrence. Only the post-discharge day at follow-up was independent predictor of both secondary endpoints occurrence. Conclusions: Hospital survival of severely ill COVID-19 patients treated with ECMO is near 50%. Age, arterial hypertension and ECMO complications are predictors of hospital mortality, and body weight and implantation in the own centre are protective. Functional recovery is only predicted by the follow-up time after discharge. A more homogeneous management of these patients is warranted for clinical results and future research optimization. |
guest ::
(Hospital Universitario 12 de Octubre (Madrid))
