Effect of Calibration for Tissue Differentiation Between Healthy and Neoplasm Lung Using Minimally Invasive Electrical Impedance Spectroscopy
Company-Se, Georgina (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica)
Nescolarde, Lexa (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica)
Pajares Ruiz, Virginia (Institut d'Investigació Biomèdica Sant Pau)
Torrego, Alfons (Institut d'Investigació Biomèdica Sant Pau)
Riu, Pere J. (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica)
Rosell Ferrer, Javier (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica)
Bragos, Ramon (Universitat Politècnica de Catalunya. Departament d'Enginyeria Electrònica)

Date:	2022
Abstract:	This study proposes a calibration method and analyses the effect of this calibration in lung measures, using minimally invasive electrical impedance spectroscopy with the 3-electrode method, for tissue differentiation between healthy and neoplasm lung tissue. Tissue measurements were performed in 99 patients [54 healthy tissue and 15 neoplastic tissue samples obtained] with an indicated bronchoscopy. Statistically significant difference (P < 0. 001) were found between healthy lung tissue and neoplasm lung tissue in bioimpedance parameters. The calibration of the bioimpedance measures with respect to a measure performed in bronchi reduces the inter-patient dispersion, increasing the sensitivity, decreasing the specificity and increasing the area below the ROC curve for three out of four impedance-derived estimators. Results also show that there are no significant differences between healthy lung tissue among smoker, non-smoker and ex-smoker samples, which was initially stated as a possible cause of EIS measurement dispersion in lungs.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bronchi ; Bronchoscopy ; Calibration ; Electrical impedance spectroscopy (EIS) ; Lung
Published in:	IEEE Access, Vol. 10 (2022) , p. 103150-103163, ISSN 2169-3536

DOI: 10.1109/ACCESS.2022.3209809

14 p, 2.0 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles