Synthesis of novel nucleoside analogues built on a bicyclo[4.1.0]heptane scaffold
Domínguez Pérez, Beatriz (Universitat Autònoma de Barcelona. Departament de Química)
Ferrer Mallofré, Èric (Universitat Autònoma de Barcelona. Departament de Química)
Figueredo Galimany, Marta (Universitat Autònoma de Barcelona. Departament de Química)
Maréchal, Jean-Didier (Universitat Autònoma de Barcelona. Departament de Química)
Balzarini, Jan (KU Leuven. Rega Institute for Medical Research)
Alibes, Ramón (Universitat Autònoma de Barcelona. Departament de Química)
Busqué Sánchez, Félix (Universitat Autònoma de Barcelona. Departament de Química)

Date:	2015
Abstract:	A new class of carbocyclic nucleoside analogues built on a bicyclo[4. 1. 0]heptane scaffold, a perspective novel pseudosugar pattern, have been conceived as anti-HSV agents on the basis of initial protein-ligand docking studies. The asymmetric synthesis of a series of these compounds incorporating different nucleobases has been efficiently completed starting from 1,4-cyclohexanedione.
Grants:	Ministerio de Economía y Competitividad CTQ2014-54071 Ministerio de Economía y Competitividad CTQ2013-41161-R
Note:	Altres ajuts: we acknowledge a grant from the Generalitatde Catalunya (to B.D.-P.)
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Alcohols ; Antimicrobial agents ; Hydrocarbons ; Nucleic acids ; Peptides and proteins
Published in:	Journal of organic chemistry, Vol. 80, issue 19 (Oct. 2015) , p. 9495-9505, ISSN 1520-6904

DOI: 10.1021/acs.joc.5b01413

Postprint 33 p, 1004.1 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Synthesis of Bioactive Organic Compounds and Functional Materials (SynOrgFUN)
Articles > Research articles
Articles > Published articles