DJ-1 administration exerts cardioprotection in a mouse model of acute myocardial infarction
Gallinat, Alex (Universitat Autònoma de Barcelona)
Mendieta, Guiomar (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau)
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Cardiovascular diseases, and particularly acute myocardial infarction (MI), are the most common causes of death worldwide. Infarct size is the major predictor of clinical outcomes in MI. The Parkinson's disease associated protein, DJ-1 (also known as PARK7), is a multifunctional protein with chaperone, redox sensing and mitochondrial homeostasis activities. Previously, we provided the evidence for a central role of endogenous DJ-1 in the cardioprotection of post-conditioning. In the present study, we tested the hypothesis that systemic administration of recombinant DJ-1 exerts cardioprotective effects in a mouse model of MI and also explored the associated transcriptional response. We report a significant treatment-induced reduction in infarct size, leukocyte infiltration, apoptosis and oxidative stress. Effects potentially mediated by G-protein-coupled receptor signaling and modulation of the immune response. Collectively, our results indicate a protective role for the exogenously administrated DJ-1 upon MI, and provide the first line of evidence for an extracellular activity of DJ-1 regulating cardiac injury in vivo.
Grants:	Agencia Estatal de Investigación SAF-2016-76819-R Agencia Estatal de Investigación PID 2019-107160RB-I00 Agencia Estatal de Investigación PGC 2018-094025-B-I00 Agencia Estatal de Investigación BES-2017-081378 Instituto de Salud Carlos III JTC 2020-023/AC 209-00054 Instituto de Salud Carlos III FIS PI19/01687
Note:	Altres ajuts: Ministerio de Ciencia e Innovación.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cardioprotection ; DJ-1 ; PARK7 ; Ischemia ; Reperfusion ; Myocardial infarction ; Ischemia/reperfusion injury
Published in:	Frontiers in Pharmacology, Vol. 13 (September 2022) , p. 1002755, ISSN 1663-9812

DOI: 10.3389/fphar.2022.1002755
PMID: 36210822

12 p, 2.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles