Multi-center study of inter-rater reproducibility, image quality, and diagnostic accuracy of CZT versus conventional SPECT myocardial perfusion imaging
Mansour, Nabeel (LMU Munich. Department of Radiology, University Hospital)
Nekolla, Stephan G. (Partner Site Munich Heart Alliance. DZHK (German Centre for Cardiovascular Research))
Reyes, Eliana (Royal Brompton and Harefield NHS Trust)
Angelidis, George (University Hospital of Larissa. Department of Nuclear Medicine, Faculty of Medicine, University of Thessaly)
Georgoulias, Panagiotis (University Hospital of Larissa. Department of Nuclear Medicine, Faculty of Medicine, University of Thessaly)
Anagnostopoulos, Constantinos (BRFAA - Biomedical Research Foundation Academy of Athens)
Bravo, Paco (Hospital of the University of Pennsylvania. Divisions of Nuclear Medicine and Cardiology, Departments of Radiology and Medicine)
Bruno, Isabella (Fondazione Policlinico Universitario Agostino Gemelli IRCCS)
Flotats, Albert (Institut d'Investigació Biomèdica Sant Pau)
Fuentes-Ocampo, Francisco (Institut d'Investigació Biomèdica Sant Pau)
Sciagrà, Roberto (University of Florence. Department of Experimental and Clinical Biomedical Sciences 'Mario Serio')
Keng, Felix (National Heart Centre)
Kessler, Lukas (University of Duisburg-Essen. Department of Nuclear Medicine, University Hospital Essen)
Papathanasiou, Maria (Department of Cardiology, West German Heart and Vascular Center, University Hospital, Essen, Germany)
Soman, Prem (University of Pittsburgh Medical Center. Division of Cardiology)
Rischpler, Christoph (University of Duisburg-Essen. Department of Nuclear Medicine, University Hospital Essen)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Cadmium-zinc-telluride (CZT)-based detectors exhibit higher diagnostic sensitivity in myocardial perfusion imaging (MPI) than conventional Anger-MPI for detection of coronary artery disease (CAD); however, reduced specificity and diagnostic accuracy of CZT-MPI were observed. This study aims to compare these different camera systems and to examine the degree of inter-rater reproducibility among readers with varying experience in MPI. 83 patients who underwent double stress/rest examinations using both a CZT and conventional SPECT cameras within one visit were included. Anonymized and randomized MPI-images were distributed to 15 international readers using a standardized questionnaire. Subsequent coronary angiography findings of ten patients served as a reference for analysis of sensitivity and specificity. Image quality was significantly better in CZT-MPI with significantly lower breast attenuation (P < 0. 05). CZT-MPI exhibited higher sensitivity than Anger-MPI (87. 5% vs. 62. 5%) and significantly reduced specificity (40% vs. 100%). Readers experienced with both camera systems had the highest inter-rater agreement indicating higher reproducibility (CZT 0. 54 vs. conv. 0. 49, P < 0. 05). Higher diagnostic sensitivity of CZT-MPI offers advantages in detection of CAD yet potentially of at the cost of reduced specificity, therefore it requires special training and a differentiated evaluation approach, especially for non-experienced readers with such camera systems. The online version contains supplementary material available at 10. 1007/s12350-022-03054-w.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cadmium-zinc-telluride ; Coronary artery disease ; Myocardial perfusion imaging ; Single-photon emission tomography
Published in:	Journal of Nuclear Cardiology, Vol. 30 (july 2022) , p. 528-539, ISSN 1532-6551

DOI: 10.1007/s12350-022-03054-w
PMID: 35799039

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