A simple new screening tool for diagnosing imported schistosomiasis
Roure, Silvia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Pérez-Quílez, Olga (Institut Català de la Salut)
Vallès, Xavier (Institut Germans Trias i Pujol)
Valerio, Lluís (Institut Català de la Salut)
Fernandez Rivas, Gema (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Rivaya, Belén (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
López-Muñoz, Israel (Institut Català de la Salut)
Soldevila Langa, Laura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Villanova, Xavier (Institut Català de la Salut)
Paredes, Roger (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Pedro-Botet, Maria-Lluïsa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Videla, Sebastián (Hospital Universitari de Bellvitge)
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	We sought to test the sensitivity and feasibility of a Schistosoma infection screening process consisting of a scored patient consultation questionnaire and a serological diagnostic test. Prospective cross-sectional study. We collected from Schistosoma-exposed individuals a 14-point check list of clinical and laboratory data related to Schistosoma infection, alongside a serological test to detect Schistosoma spp infection. A check list score was created and compared with the risk of infection and clinical recovery through an agreement analysis. Two-hundred and fifty individuals were enrolled, of whom 220 (88%) were male and 30 (12%) female. The median age was 39 (range 18-78). One hundred-fifty (60%, 95% CI 54. 9%-65. 1%) had a check-list score ≥2. Serology test results were positive for 142 (56. 8%, 95% CI 51. 6%-62%). Chronic complications compatible with long-term Schistosoma infection were detected in 29 out of these 142 (20. 4%, 95% CI 13. 8%-27%). ,. The median score value was 3, the area under the receiver operating characteristic (ROC) curve against serology results was 0. 85 and the estimated intercept check-list questionnaire score value was 1. 72 (95%, CI: 1. 3-2. 2). Participants with a positive serological test had a substantially higher check-list score (Cohen's kappa coefficient: 0. 62, 95% CI: 0. 54-0. 70). Ninety four percent patients empirically treated showed a subsequent improvement in clinical and laboratory parameters. A two-component process consisting of a scored patient consultation questionnaire followed by serological assay can be a suitable strategy for screening populations at high risk of schistosomiasis infection.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Imported disease ; Migrant population ; Schistosomiasis ; Screening
Published in:	Public Health in Practice, Vol. 3 (march 2022) , ISSN 2666-5352

DOI: 10.1016/j.puhip.2022.100245
PMID: 36101771

6 p, 1.3 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles