Cognitive Performance and Health-Related Quality of Life in Patients with Neuromyelitis Optica Spectrum Disorder
Lopez-Soley, Elisabet (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Meca-Lallana, Jose E. (Instituto Murciano de Investigación Biosanitaria)
Llufriu, Sara (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Blanco, Yolanda (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Gómez-Ballesteros, Rocío (Medical Department. Roche Farma)
Maurino, Jorge (Medical Department. Roche Farma)
Pérez-Miralles, Francisco (Hospital Universitari i Politècnic La Fe (València))
Forero, Lucía (Hospital Universitario Puerta del Mar (Cadis, Andalusia))
Calles, Carmen (Hospital Universitario Son Espases. Servicio de Neurología)
Martinez-Gines, María L. (Hospital General Universitario Gregorio Marañón)
Gonzalez-Suarez, Inés (Hospital Álvaro Cunqueiro. Servicio de Neurología)
Boyero, Sabas (Hospital Universitario de Cruces (Barakaldo, País Basc))
Romero-Pinel, Lucía (Hospital Universitari de Bellvitge)
Sempere, Ángel P. (Hospital General Universitario de Alicante (Alacant, País Valencià))
Meca-Lallana, Virginia (Hospital Universitario de La Princesa. Servicio de Neurología)
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau)
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid))
Sepulveda, Maria (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Solana, Elisabeth (Institut d'Investigacions Biomèdiques August Pi i Sunyer)

Date:	2022
Abstract:	(1) Background: The frequency of cognitive impairment (CI) reported in neuromyelitis optica spectrum disorder (NMOSD) is highly variable, and its relationship with demographic and clinical characteristics is poorly understood. We aimed to describe the cognitive profile of NMOSD patients, and to analyse the cognitive differences according to their serostatus; furthermore, we aimed to assess the relationship between cognition, demographic and clinical characteristics, and other aspects linked to health-related quality of life (HRQoL). (2) Methods: This cross-sectional study included 41 patients (median age, 44 years; 85% women) from 13 Spanish centres. Demographic and clinical characteristics were collected along with a cognitive z-score (Rao's Battery) and HRQoL patient-centred measures, and their relationship was explored using linear regression. We used the Akaike information criterion to model which characteristics were associated with cognition. (3) Results: Fourteen patients (34%) had CI, and the most affected cognitive domain was visual memory. Cognition was similar in AQP4-IgG-positive and-negative patients. Gender, mood, fatigue, satisfaction with life, and perception of stigma were associated with cognitive performance (adjusted R = 0. 396, p < 0. 001). (4) Conclusions: The results highlight the presence of CI and its impact on HRQoL in NMOSD patients. Cognitive and psychological assessments may be crucial to achieve a holistic approach in patient care.
Note:	Altres ajuts: Medical Department of Roche Farma Spain (ML41397).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Neuromyelitis optica spectrum disorder ; Cognition ; Health-related quality of life ; Mood
Published in:	Journal of personalized medicine, Vol. 12 Núm. 5 (may 2022) , p. 743, ISSN 2075-4426

DOI: 10.3390/jpm12050743
PMID: 35629165

11 p, 557.0 KB

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Articles > Research articles
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