Accuracy and Survival Outcomes after National Implementation of Sentinel Lymph Node Biopsy in Early Stage Endometrial Cancer
Cabrera Díaz, Silvia (Hospital Universitari Vall d'Hebron)
Gómez-Hidalgo, Natalia R (Hospital Universitari Vall d'Hebron)
Bebia, Vicente (Hospital Universitari Vall d'Hebron)
Fernández-González, Sergi (Hospital Universitari de Bellvitge)
Fusté, Pere (Hospital Clínic i Provincial de Barcelona)
Martínez, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gil-Moreno, Antonio 1965- (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Imprint:	Springer New York, 2023
Description:	10 pàg.
Abstract:	Sentinel lymph node (SLN) biopsy has recently been accepted to evaluate nodal status in endometrial cancer at early stage, which is key to tailoring adjuvant treatments. Our aim was to evaluate the national implementation of SLN biopsy in terms of accuracy to detect nodal disease in a clinical setting and oncologic outcomes according to the volume of nodal disease. A total of 29 Spanish centers participated in this retrospective, multicenter registry including patients with endometrial adenocarcinoma at preoperative early stage who had undergone SLN biopsy between 2015 and 2021. Each center collected data regarding demographic, clinical, histologic, therapeutic, and survival characteristics. A total of 892 patients were enrolled. After the surgery, 12. 9% were suprastaged to FIGO 2009 stages III-IV and 108 patients (12. 1%) had nodal involvement: 54. 6% macrometastasis, 22. 2% micrometastases, and 23. 1% isolated tumor cells (ITC). Sensitivity of SLN biopsy was 93. 7% and false negative rate was 6. 2%. After a median follow up of 1. 81 years, overall surivial and disease-free survival were significantly lower in patients who had macrometastases when compared with patients with negative nodes, micrometastases or ITC. In our nationwide cohort we obtained high sensitivity of SLN biopsy to detect nodal disease. The oncologic outcomes of patients with negative nodes and low-volume disease were similar after tailoring adjuvant treatments. In total, 22% of patients with macrometastasis and 50% of patients with micrometastasis were at low risk of nodal metastasis according to their preoperative risk factors, revealing the importance of SLN biopsy in the surgical management of patients with early stage EC.
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	SDG 3 - Good Health and Well-being
Published in:	Annals of Surgical Oncology, ISSN 1534-4681

DOI: 10.1245/s10434-023-14065-3
DOI: 10.1245/s10434-023-14068-0
PMID: 37633852
PMID: 37552347

10 p, 564.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles