The novel inflammatory biomarker GlycA and triglyceride-rich lipoproteins are associated with the presence of subclinical myocardial dysfunction in subjects with type 1 diabetes mellitus
Puig-Jové, Carlos (Universitat Autònoma de Barcelona. Departament de Medicina)
Julve i Gil, Josep (Institut d'Investigació Biomèdica Sant Pau)
Castelblanco, Esmeralda (Washington University School of Medicine)
Julián, María Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Amigó, Núria (Universitat Rovira i Virgili)
Andersen, Henrik U (Steno Diabetes Center Copenhagen)
Ahluwalia, Tarunveer S (University of Copenhagen)
Rossing, Peter (University of Copenhagen)
Mauricio Puente, Dídac (Institut d'Investigació Biomèdica Sant Pau)
Jensen, Magnus T (Copenhagen University Hospital Amager Hvidovre)
Alonso Pedrol, Núria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)

Fecha:	2022
Resumen:	Subjects with Type 1 diabetes mellitus (T1DM) have an increased incidence of heart failure (HF). Several pathophysiological mechanisms have been involved in its development. The aim of this study was to analyze the potential contribution of the advanced lipoprotein profile and plasma glycosylation (GlycA) to the presence of subclinical myocardial dysfunction in subjects with T1DM. We included subjects from a Danish cohort of T1DM subjects (Thousand & 1 study) with either diastolic and/or systolic subclinical myocardial dysfunction, and a control group without myocardial dysfunction, matched by age, sex and HbA1c. All underwent a transthoracic echocardiogram and an advanced lipoprotein profile obtained by using the NMR-based Liposcale® test. GlycA NMR signal was also analyzed. Systolic dysfunction was defined as left ventricular ejection fraction ≤ 45% and diastolic dysfunction was considered as E/e'≥12 or E/e' 8-12 + volume of the left atrium > 34 ml/m2. To identify a metabolic profile associated with the presence of subclinical myocardial dysfunction, a multivariate supervised model of classification based on least squares regression (PLS-DA regression) was performed. One-hundred forty-six subjects had diastolic dysfunction and 18 systolic dysfunction. Compared to the control group, patients with myocardial dysfunction had longer duration of diabetes (p = 0. 005), and higher BMI (p = 0. 013), serum NTproBNP concentration (p = 0. 001), systolic blood pressure (p < 0. 001), albuminuria (p < 0. 001), and incidence of advanced retinopathy (p < 0. 001). The supervised classification model identified a specific pattern associated with myocardial dysfunction, with a capacity to discriminate patients with myocardial dysfunction from controls. PLS-DA showed that triglyceride-rich lipoproteins (TGRLs), such as VLDL (total VLDL particles, large VLDL subclass and VLDL-TG content) and IDL (IDL cholesterol content), as well as the plasma concentration of GlycA, were associated with the presence of subclinical myocardial dysfunction. Proatherogenic TGRLs and the proinflammatory biomarker Glyc A are strongly associated to myocardial dysfunction in T1DM. These findings suggest a pivotal role of TGRLs and systemic inflammation in the development of subclinical myocardial dysfunction in T1DM. The online version contains supplementary material available at 10. 1186/s12933-022-01652-z.
Ayudas:	Instituto de Salud Carlos III PI17/00232 Instituto de Salud Carlos III PI17/01362 Ministerio de Economía y Competitividad CB15/00071
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	GlycA ; Heart failure ; Lipoproteins ; Myocardial dysfunction ; Type 1 diabetes
Publicado en:	Cardiovascular diabetology, Vol. 21 (november 2022) , ISSN 1475-2840

DOI: 10.1186/s12933-022-01652-z
PMID: 36434633

11 p, 1.1 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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