Effects and mechanisms of mindfulness training and physical exercise on cognition, emotional wellbeing, and brain outcomes in chronic stroke patients : Study protocol of the MindFit project randomized controlled trial
Bermudo-Gallaguet, Adrià (Institut de Recerca Sant Joan de Déu)
Ariza, Mar (Universitat de Barcelona)
Dacosta Aguayo, Rosalia (Institut Universitari d'Investigació en Atenció Primària Jordi Gol)
Agudelo, Daniela (Universitat de Barcelona)
Camins-Vila, Neus (Institut Nacional d'Educació Física de Catalunya)
Boldo Alcaine, Maria (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Carrera, Òscar (Universitat de Barcelona)
Vidal, Sandra (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ferrer-Uris, Blai (Institut Nacional d'Educació Física de Catalunya)
Busquets, Albert (Institut Nacional d'Educació Física de Catalunya)
Via, Marc (Institut de Recerca Sant Joan de Déu)
Pera, Guillem (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Cáceres, Cynthia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gomis, Meritxell (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García-Molina, Alberto (Institut Germans Trias i Pujol. Institut Guttmann)
Tormos, Jose M (Institut Germans Trias i Pujol. Institut Guttmann)
Arrabé, Ana (Universidad Complutense de Madrid)
Diez, Gustavo (Universidad Complutense de Madrid)
Dura Mata, Maria Jose (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Torán Montserrat, Pere (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Soriano-Raya, Juan José (Universitat de Barcelona)
Domènech, Sira (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Perera-Lluna, Alexandre (Universitat Politècnica de Catalunya)
Erickson, Kirk I. (Universidad de Granada)
Mataró, Maria (Institut de Recerca Sant Joan de Déu)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Post-stroke cognitive and emotional complications are frequent in the chronic stages of stroke and have important implications for the functionality and quality of life of those affected and their caregivers. Strategies such as mindfulness meditation, physical exercise (PE), or computerized cognitive training (CCT) may benefit stroke patients by impacting neuroplasticity and brain health. One hundred and forty-one chronic stroke patients are randomly allocated to receive mindfulness-based stress reduction + CCT (n = 47), multicomponent PE program + CCT (n = 47), or CCT alone (n = 47). Interventions consist of 12-week home-based programs five days per week. Before and after the interventions, we collect data from cognitive, psychological, and physical tests, blood and stool samples, and structural and functional brain scans. The effects of the interventions on cognitive and emotional outcomes will be described in intention-to-treat and per-protocol analyses. We will also explore potential mediators and moderators, such as genetic, molecular, brain, demographic, and clinical factors in our per-protocol sample. The MindFit Project is a randomized clinical trial that aims to assess the impact of mindfulness and PE combined with CCT on chronic stroke patients' cognitive and emotional wellbeing. Furthermore, our design takes a multimodal biopsychosocial approach that will generate new knowledge at multiple levels of evidence, from molecular bases to behavioral changes. , identifier NCT04759950.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biomarkers ; Computerized cognitive training ; Mindfulness ; Neuroimaging ; Physical exercise ; Stroke
Published in:	Frontiers in aging neuroscience, Vol. 14 (september 2022) , ISSN 1663-4365

DOI: 10.3389/fnagi.2022.936077
PMID: 36248000

15 p, 1.6 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles