Sentinel Lymph Node Biopsy vs. Observation in Thin Melanoma : A Multicenter Propensity Score Matching Study
Tejera-Vaquerizo, Antonio (Hospital San Juan de Dios)
Boada, Aram (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Ribero, Simone (University of Turin)
Puig, Susana (Hospital Clínic i Provincial de Barcelona)
Paradela, Sabela (Hospital Universitario de la Coruña)
Moreno-Ramírez, David (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Cañueto, Javier (Complejo Asistencial Universitario de Salamanca)
de Unamuno-Bustos, Blanca (Hospital Universitari i Politècnic La Fe (València))
Brinca, Ana (University Hospital of Coimbra)
Descalzo-Gallego, Miguel A. (Fundación Piel Sana)
Osella-Abate, Simona (University of Turin)
Cassoni, Paola (University of Turin)
Podlipnik, Sebastian (Hospital Clínic i Provincial de Barcelona)
Carrera, Cristina (Hospital Clínic i Provincial de Barcelona)
Vidal-Sicart, Sergi (Hospital Clínic i Provincial de Barcelona)
Pigem, Ramón (Hospital Clínic i Provincial de Barcelona)
Toll Abelló, Agustí (Hospital Clínic i Provincial de Barcelona)
Rull, Ramón (Hospital Clínic i Provincial de Barcelona)
Alos, Llucìa (Hospital Clínic i Provincial de Barcelona)
Requena, Celia (Fundació Institut Valencià d'Oncologia)
Bolumar, Isidro (Fundació Institut Valencià d'Oncologia)
Traves, Víctor (Fundació Institut Valencià d'Oncologia)
Pla, Ángel (Fundació Institut Valencià d'Oncologia)
Fernández-Orland, Almudena (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Jaka, Ane (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Fernandez Figueras, Maria Teresa (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Richarz, Nina Anika (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Vieira, Ricardo (University Hospital of Coimbra)
Botella-Estrada, Rafael (Hospital Universitari i Politècnic La Fe (València))
Román-Curto, Concepción (Complejo Asistencial Universitario de Salamanca)
Ferrándiz-Pulido, Lara (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Iglesias-Pena, Nicolás (Hospital Universitario de la Coruña)
Ferrándiz, Carlos (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Malvehy, Josep (Hospital Clínic i Provincial de Barcelona)
Quaglino, Pietro (University of Turin)
Nagore, Eduardo (Fundació Institut Valencià d'Oncologia)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	The therapeutic value of sentinel lymph node biopsy (SLNB) in thin melanoma remains controversial. The aim of this study is to determine the role of SLNB in the survival of thin melanomas (≤1 mm). A multicenter retrospective observational study was designed. A propensity score matching was performed to compare patients who underwent SLNB vs. observation. A multivariate Cox regression was used. A total of 1438 patients were matched by propensity score. There were no significant differences in melanoma-specific survival (MSS) between the SLNB and observation groups. Predictors of MSS in the multivariate model were age, tumor thickness, ulceration, and interferon treatment. Results were similar for disease-free survival and overall survival. The 5- and 10-year MSS rates for SLN-negative and -positive patients were 98. 5% vs. 77. 3% (p < 0. 001) and 97. 3% vs. 68. 7% (p < 0. 001), respectively. SLNB does not improve MSS in patients with thin melanoma. It also had no impact on DSF or OS. However, a considerable difference in MSS, DFS, and OS between SLN-positive and -negative patients exists, confirming its value as a prognostic procedure and therefore we recommend discussing the option of SLNB with patients.
Grants:	Ministerio de Economía y Competitividad PI15/00956 Ministerio de Economía y Competitividad PI12/00840 Ministerio de Economía y Competitividad PI15/00716 Instituto de Salud Carlos III PI18/00419
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Melanoma ; Sentinel lymph node biopsy ; Survival
Published in:	Journal of clinical medicine, Vol. 10 (december 2021) , ISSN 2077-0383

DOI: 10.3390/jcm10245878
PMID: 34945175

14 p, 1.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles