Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation : Insights from the OCTOPUS-CHF Study
Martínez-Solano, Jorge (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Gutiérrez-Ibañes, Enrique (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Ortiz-Bautista, Carlos (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
García-Cosío, María Dolores (Hospital 12 de Octubre (Madrid))
Sarnago-Cebada, Fernando (Hospital 12 de Octubre (Madrid))
Díaz-Molina, Beatriz (Hospital Universitario Central de Asturias. Servicio de Cardiología)
Pascual, Isaac (Hospital Universitario Central de Asturias. Servicio de Cardiología)
Oteo-Domínguez, Juan Francisco (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Gómez-Bueno, Manuel (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Calviño-Santos, Ramón (Complejo Hospitalario Universitario de A Coruña)
Crespo-Leiro, Maria Generosa (Complejo Hospitalario Universitario de A Coruña)
Gómez-Hospital, Joan Antoni (Hospital Universitari de Bellvitge. Servei de Cardiologia)
Díez-López, Carles (Hospital Universitari de Bellvitge. Servei de Cardiologia)
García-Lara, Juan (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
Garrido Bravo, Iris (Hospital Clínico Universitario Virgen de la Arrixaca (El Palmar, Múrcia))
de la Fuente-Galán, Luis (Hospital Clínico Universitario de Valladolid)
López-Díaz, Javier (Hospital Clínico Universitario de Valladolid)
Mirabet Pérez, Sonia (Institut d'Investigació Biomèdica Sant Pau)
Martínez-Sellés, Manuel (Universidad Europea de Madrid. Facultad de Ciencias Biomédicas y de la Salud)

Date:	2022
Abstract:	Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization data, and the echocardiographic estimation of pulmonary pressure in patients studied for elective heart transplants. Methods: This research is an observational, prospective, multicenter study involving 90 adults with a one-year follow-up. Results: A total of 10 patients (11. 1%) died due to worsening heart failure before heart transplantation, 50 underwent a heart transplant (55. 6%), and 9 died in the first year after the transplant. The patients with and without events (mortality or heart failure-induced hospitalization) had similar data regarding echocardiography, right heart catheterization, and pulmonary OCT (with a median estimated pulmonary artery systolic pressure of 42. 0 mmHg, interquartile range (IQR) of 30. 3-50. 0 vs. 47. 0 mmHg, IQR 34. 6-59. 5 and p = 0. 79, median pulmonary vascular resistance of 2. 2 Wood units, IQR 1. 3-3. 7 vs. 2. 0 Wood units, IQR 1. 4-3. 2 and p = 0. 99, and a median pulmonary artery wall thickness of 0. 2 ± 0. 5 mm vs. 0. 2 ± 0. 6 mm and p = 0. 87). Conclusion: Pulmonary vascular remodeling (evaluated with echocardiography, right heart catheterization, and pulmonary OCT) was not associated with prognosis in a selected sample of adults evaluated for elective heart transplants. Pulmonary OCT is safe and feasible for the evaluation of these patients.
Grants:	Instituto de Salud Carlos III PI18/00254 European Commission CB16/11/00502
Note:	Altres ajuts: European Regional Development Fund.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Pulmonary hypertension ; Pulmonary vascular remodeling ; Advanced heart failure ; Optical coherence tomography ; Intravascular imaging ; Right heart catheterization ; Heart transplant
Published in:	Journal of Cardiovascular Development and Disease, Vol. 9 Núm. 12 (december 2022) , p. 439, ISSN 2308-3425

DOI: 10.3390/jcdd9120439
PMID: 36547436

10 p, 946.8 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles