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| Pàgina inicial > Articles > Articles publicats > Brain aging in major depressive disorder : |
(Vrije Universiteit & GGZinGeest) (University of Southern California) (University of California San Diego) (Vrije Universiteit & GGZinGeest) (University of Groningen) (The University of Melbourne) (Novosibirsk State University) (Universidade de Sao Paulo) (Florida State University) (University of Queensland) (University of Münster) (The University of Melbourne) (King's College London) (Universidade de Sao Paulo) (University of Münster) (Cognitive & Translational Neuroscience) (University Medicine Greifswald) (German Center for Neurodegenerative Diseases (DZNE)) (University of East London) (University of Oxford) (Stanford University) (German Center for Neurodegenerative Diseases) (University of Cape Town) (The University of Melbourne & Melbourne Health) (University of California San Diego) (University of Münster) (University of Sydney) (Philipps-University Marburg) (University of Minnesota) (University of Heidelberg) (University of Bonn) (Addictions and Mental Health Strategic Clinical Network) (University of Edinburgh) (University of Alberta) (Queensland University of Technology) (QIMR Berghofer Medical Research Instititute) (University of Minnesota Medical School) (DepartThe University of Texas Health Science Center at Houston) (Novosibirsk State University) (Institut d'Investigació Biomèdica Sant Pau) (The University of Melbourne & Melbourne Health) (Amsterdam UMC. University Medical Center) (University of Münster) (Amsterdam UMC. University Medical Center) (The University of Texas Health Science Center at Houston) (University of Cape Town) (University of Queensland) (University of Southern California) (University of Groningen) (Charité - Universitätsmedizin Berlin) (University of Edinburgh) (German Center of Neurodegenerative Diseases (DZNE) Site Rostock/Greifswald) (University of Queensland) (The University of Texas Health Science Center at Houston) (University Medicine Greifswald) (Queensland University of Technology) (Karolinska Institutet (Estocolm, Suècia)) (Dalhousie University) (Oslo University Hospital (Oslo, Noruega)) (Oslo University Hospital (Oslo, Noruega)) (Hospital Clínic i Provincial de Barcelona) (FIDMAG Germanes Hospitalàries Research Foundation) (National University of Ireland Galway) (Cardiff University) (Hôpitaux Universitaires Mondor) (Cardiff University) (University of New South Wales) (Hospital Clínic i Provincial de Barcelona) (University of Groningen) (Hôpitaux Universitaires Mondor) (University of Cape Town) (Karolinska Institutet (Estocolm, Suècia)) (University of Sao Paulo (FMUSP)) (University of Sao Paulo (FMUSP)) (Oslo University Hospital (Oslo, Noruega)) (National University of Ireland Galway) (National University of Ireland Galway) (Universidade de Sao Paulo) (Neuroscience Research Australia) (FIDMAG Germanes Hospitalàries Research Foundation) (Hospital Clínic i Provincial de Barcelona) (FIDMAG Germanes Hospitalàries Research Foundation) (FIDMAG Germanes Hospitalàries Research Foundation) (University of Pennsylvannia Perelman School of Medicine) (The University of Tulsa) (University of New South Wales) (Universidade de Sao Paulo) (National University of Singapore) (University of Sao Paulo (FMUSP)) (University of California San Diego) (University of Cape Town) (Hospital Clínic i Provincial de Barcelona) (Hospital Sírio-Libanês) (University of Southern California) (Vrije Universiteit & GGZinGeest) (Radboud University Medical Centre) (University College London) (The University of Melbourne)| Data: | 2021 |
| Resum: | Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1. 08 (SE 0. 22) years (Cohen's d = 0. 14, 95% CI: 0. 08-0. 20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates. |
| Ajuts: | Ministerio de Economía y Competitividad CPII16/00018 Ministerio de Economía y Competitividad PI14/01151 Ministerio de Economía y Competitividad PI14/01148 Ministerio de Economía y Competitividad PI15/00283 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Depression ; Neuroscience |
| Publicat a: | Molecular psychiatry, Vol. 26 Núm. 9 (september 2021) , p. 5124-5139, ISSN 1476-5578 |
