Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder : results from the ENIGMA MDD Working Group
Leerssen, Jeanne (Vrije Universiteit Amsterdam)
Blanken, Tessa F (Vrije Universiteit Amsterdam)
Pozzi, Elena (The National Centre of Excellence in Youth Mental Health)
Jahanshad, Neda (University of Southern California)
Aftanas, Lyubomir (Novosibirsk State University)
Andreassen, Ole A (University of Oslo)
Baune, Bernhard T. (The University of Melbourne)
Brak, Ivan (Scientific Research Institute of Neuroscience & Medicine)
Carballedo, Angela (Trinity College Dublin)
Ching, Christopher R. K (University of Southern California)
Dannlowski, Udo (University of Münster)
Dohm, Katharina (University of Münster)
Enneking, Verena (University of Münster)
Filimonova, Elena (Scientific Research Institute of Neuroscience & Medicine)
Fingas, Stella M. (University of Münster)
Frodl, Thomas (Otto von Guericke University Magdeburg)
Godlewska, Beata R. (University of Oxford)
Goltermann, Janik (University of Münster)
Gotlib, Ian H. (Stanford University)
Grotegerd, Dominik (University of Münster)
Gruber, Oliver (Heidelberg University)
Harris, Mathew A. (University of Edinburgh)
Hatton, Sean N. (University of Sydney)
Hawkins, Emma (University of Edinburgh)
Hickie, Ian B. (University of Sydney)
Jaworska, Natalia (University of Ottawa)
Kircher, Tilo (Philipps-University Marburg)
Krug, Axel (University of Bonn)
Lagopoulos, Jim (Sunshine Coast Mind and Neuroscience Thompson Institute)
Lemke, Hannah (University of Münster)
Li, Meng (Max Planck Institute for Biological Cybernetics)
MacMaster, Frank P. (Strategic Clinical Network for Addictions and Mental Health)
McIntosh, Andrew M. (University of Edinburgh)
McLellan, Quinn (University of Alberta)
Meinert, Susanne (University of Münster)
Mwangi, Benson (University of Texas Health Science Center at Houston)
Nenadić, Igor (Philipps-University Marburg)
Osipov, Evgeny (Scientific Research Institute of Neuroscience & Medicine)
Portella Moll, Maria Jesús (Institut d'Investigació Biomèdica Sant Pau)
Redlich, Ronny (University of Halle)
Repple, Jonathan (University of Münster)
Sacchet, Matthew D. (Harvard Medical School)
Sämann, Philipp G. (Max Planck Institute of Psychiatry)
Simulionyte, Egle (Heidelberg University)
Soares, Jair C. (University of Texas Health Science Center at Houston)
Walter, Martin (University of Tübingen)
Watanabe, Norio (Kyoto University)
Whalley, Heather (University of Edinburgh)
Yüksel, Dilara (SRI International)
Veltman, Dick J. (Amsterdam UMC. University Medical Center)
Thompson, Paul M. (University of Southern California)
Schmaal, Lianne (The University of Melbourne)
Van Someren, Eus J.W. (VU University)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of overall depression severity. Disease specificity was evaluated in two independent samples comprising 2108 healthy controls, and in 260 clinical controls with bipolar disorder. Results showed that MDD patients with more severe insomnia had a smaller cortical surface area, mostly driven by the right insula, left inferior frontal gyrus pars triangularis, left frontal pole, right superior parietal cortex, right medial orbitofrontal cortex, and right supramarginal gyrus. Associations were specific for insomnia severity, and were not found for overall depression severity. Associations were also specific to MDD; healthy controls and clinical controls showed differential insomnia severity association profiles. The findings indicate that MDD patients with more severe insomnia show smaller surfaces in several frontoparietal cortical areas. While explained variance remains small, symptom-specific associations could bring us closer to clues on underlying biological phenomena of MDD.
Ajuts:	Ministerio de Economía y Competitividad PI13/01057
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Depression ; Human behaviour
Publicat a:	Translational psychiatry, Vol. 10 Núm. 1 (december 2020) , p. 425, ISSN 2158-3188

DOI: 10.1038/s41398-020-01109-5
PMID: 33293520

11 p, 870.1 KB

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