Availability in Spain of "one pill killers" and other highly toxic drugs in infants Disponibilidad en España de «one pill killers» y otros medicamentos altamente tóxicos en la infancia
Martínez-Sánchez, Lidia (Sociedad Española de Farmacia Hospitalaria-Societat Catalana de Farmàcia Clínica)
Aguilar-Salmerón, Raquel (Hospital Universitari de Girona Doctor Josep Trueta)
Pi-Sala, Núria (Clínica Girona)
Gispert-Ametller, Maria Àngels (Hospital Universitari de Girona Doctor Josep Trueta)
García-Peláez, Milagros (Hospital ASEPEYO Sant Cugat)
Broto-Sumalla, Antoni (Consorci Sanitari de Terrassa)
Fernández de Gamarra Martínez, Edurne (Institut d'Investigació Biomèdica Sant Pau)
Nogué-Xarau, Santiago (Hospital Clínic i Provincial de Barcelona)
Universitat Autònoma de Barcelona

Data:	2020
Resum:	To prepare a list of highly toxic drugs in infants (HTDs) marketed in Spain, comparing those that reach the lethal dose in a child of 10 kg with the ingestion of 1 to 3 units. HTDs are defined as those capable of causing severe or lethal poisoning in children less than 8-year-old. Severe poisoning is considered as that corresponding to Grade 3 in the Poisoning Severity Score classification and to the "major effects" category in publications in the American Association of Poison Control Centers. A literature review was carried out on the annual reports of the American Association of Poison Control Centers, as well as in PubMed, between January 2000 and February 2019 (Keywords "severe", "fatal", "life-threatening", "poisoning", "child", "paediatric", "toxicological emergency"). An observational, retrospective study was also conducted on infants less than 8-year-old that were seen in a Paediatric Emergency Department due to suspected drug poisoning between July 2012 and June 2018. The active ingredients responsible marketed in Spain were selected, and the lethal or highly toxic doses were determined. The number of units (pills) necessary to reach this dose in children of 10 kg was calculated. A total of 7 HTD groups were identified: analgesics; psychotropics and other medication used in neurological disorders; catarrh decongestants - cough -antihistamine - asthma drugs; cardiovascular drugs; antibiotics, topical preparations, and other drugs. In 29 active ingredients, the ingestion of a single pill could cause death in 10 kg infant, in another 13, the ingestion of 2 pills could cause death, as well as the ingestion of 3 pills in 10 cases. There are numerous HTDs marketed in Spain, some of which are available in potentially fatal presentations with few pills.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Castellà
Document:	Article ; recerca ; Versió publicada
Matèria:	Emergencia toxicológica ; Grave ; Ingesta ; Intoxicación ; Mortal ; Pediatría
Publicat a:	Anales de pediatría, Vol. 93 Núm. 6 (diciembre 2020) , p. 380-395, ISSN 1695-9531

DOI: 10.1016/j.anpedi.2020.02.012
PMID: 32284232

16 p, 746.7 KB

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