Diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders : A systematic review protocol Precisión diagnóstica de biomarcadores salivales para cáncer oral y desórdenes potencialmente malignos: protocolo de revisión sistemática
Madera, Meisser (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Ariel Franco, J.V. (Instituto Universitario Hospital Italiano)
Solà, Ivan (Institut d'Investigació Biomèdica Sant Pau)
Bonfill, X. (Xavier) (Institut d'Investigació Biomèdica Sant Pau)
Arevalo-Rodriguez, Ingrid (Hospital Universitario Ramón y Cajal (Madrid))
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Oral cancer has a 5-year survival rate of 50% because diagnosis is commonly performed at an advanced stage of the disease, so new diagnostic tools are needed. Nowadays, there is a vast number of publications suggesting the use of salivary biomarkers for oral cancer and potentially malignant disorders diagnosis, but their diagnostic accuracy is unclear. Thus, the goal of this systematic review is to evaluate the diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders. This protocol is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P). We will include primary studies assessing the diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders. Studies must report data about sensitivity and specificity; gold standard must be the histopathology diagnosis. We will search MEDLINE, EMBASE, the Cochrane Library, and gray literature. Two authors will independently select the studies and extract the data. The methodology quality of studies will be determined using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). Our findings will provide information about the diagnostic accuracy of salivary biomarkers for oral cancer and potentially malignant disorders.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Castellà
Document:	Article ; recerca ; Versió publicada
Subject:	Biomarkers ; Diagnosis ; Mouth neoplasms ; Saliva ; Sensitivity ; Specificity
Published in:	Medwave, Vol. 20 Núm. 5 (junio 2020) , p. e7938, ISSN 0717-6384

DOI: 10.5867/medwave.2020.05.7938
PMID: 32603320

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles