Chronic nodular prurigo : clinical profile and burden. A European cross-sectional study
Pereira, Manuel Pedro (University Hospital of Münster (Alemanya))
Hoffmann, V. (University Hospital of Münster (Alemanya))
Weisshaar, E. (University of Heidelberg)
Wallengren, J. (Dermatology and Venereology and Skane University Hospital)
Halvorsen, J.A. (Oslo University Hospital (Oslo, Noruega))
Garcovich, S. (Università Cattolica del Sacro Cuore)
Misery, L. (University Hospital of Brest)
Brenaut, Emilie (University Hospital of Brest)
Savk, E. (Aydin Adnan Menderes University)
Potekaev, N. (Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology)
Lvov, A. (Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology)
Bobko, Svetlana (Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology)
Szepietowski, J.C. (Wroclaw Medical University)
Reich, A. (University of Rzeszów)
Bożek, Agnieszka (University of Information Technology and Management)
Legat, F.J. (Medical University of Graz)
Metz, M. (Charité - Universitätsmedizin Berlin)
Streit, M. (Kantonsspital Aarau)
Serra-Baldrich, E (Institut d'Investigació Biomèdica Sant Pau)
Gonçalo, Margarida (University of Coimbra)
Storck, M. (University of Münster)
Greiwe, I. (University Hospital of Münster (Alemanya))
Nau, T. (University Hospital of Münster (Alemanya))
Steinke, S. (University Hospital of Münster (Alemanya))
Dugas, M. (University of Münster)
Ständer, S. (University Hospital of Münster (Alemanya))
Zeidler, Claudia (University Hospital of Münster (Alemanya))
Dalgard, F.
Elberling, J.
Forner, C.
Leslie, T.
Riepe, C.
Schneider, G.
Ständer, H.
Universitat Autònoma de Barcelona

Data:	2020
Resum:	Chronic nodular prurigo (CNPG) is a condition characterized by chronic itch, a prolonged scratching behaviour and the presence of pruriginous nodules. A comprehensive understanding of this condition, especially regarding its clinical characteristics and impact on quality of life is still lacking. Aim of this pan-European multicentre cross-sectional study was to establish the clinical profile of CNPG, including its associated burden. Fifteen centres from 12 European countries recruited CNPG patients presenting at the centre or using the centres' own databases. Patients were asked to complete a questionnaire in paper or electronic format. Demography, current co-morbidities, underlying disease, itch intensity, additional sensory symptoms, quality of life, highest burden and emotional experience of itch were assessed. A total of 509 patients (210 male, median age: 64 years [52; 72]) were enrolled. Of these, 406 reported itch and CNPG lesions in the previous 7 days and qualified to complete the whole questionnaire. We recorded moderate to severe worst itch intensity scores in the previous 24 h. Scores were higher in patients with lower educational levels and those coming from Eastern or Southern Europe. Most patients experience itch often or always (71%) and report that their everyday life is negatively affected (53%). Itch intensity was considered to be the most burdensome aspect of the disease by 49% of the patients, followed by the visibility of skin lesions (21%) and bleeding of lesions (21%). The majority of patients was unaware of an underlying condition contributing to CNPG (64%), while psychiatric diseases were the conditions most often mentioned in association with CNPG (19%). This multicentre cross-sectional study shows that itch is the dominant symptom in CNPG and reveals that the profile of the disease is similar throughout Europe.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Chronic Disease ; Cross-Sectional Studies ; Europe ; Humans ; Male ; Middle Aged ; Prurigo ; Pruritus ; Quality of Life
Publicat a:	Journal of the European Academy of Dermatology and Venereology, Vol. 34 Núm. 10 (january 2020) , p. 2373-2383, ISSN 1468-3083

DOI: 10.1111/jdv.16309
PMID: 32078192

11 p, 349.0 KB

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