The Kappa Opioid Receptor and the Sleep of Reason : Cortico-Subcortical Imbalance Following Salvinorin-A
Oña, Genís (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau)
Romero, Sergio (Universitat Politècnica de Catalunya)
Valle, Marta (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Camacho, Valle (Institut d'Investigació Biomèdica Sant Pau)
Migliorelli, Carolina (Universitat Politècnica de Catalunya)
Mañanas, Miguel Ángel (Universitat Politècnica de Catalunya)
Antonijoan Arbós, Rosa Ma. (Institut d'Investigació Biomèdica Sant Pau)
Puntes, Montserrat (Institut d'Investigació Biomèdica Sant Pau)
Coimbra, Jimena (Institut d'Investigació Biomèdica Sant Pau)
Ballester, Maria Rosa (Institut d'Investigació Biomèdica Sant Pau)
Garrido, Maite (Institut d'Investigació Biomèdica Sant Pau)
Riba, Jordi (Maastricht University)

Date:	2021
Abstract:	The mechanisms through which kappa opioid receptor (KOR) agonists induce psychotomimetic effects are largely unknown, although the modulation of this receptor has attracted attention for its clinical use. In this work, we characterize the neuropharmacological effects of salvinorin-A, a highly selective KOR agonist. Changes in multimodal electroencephalography, single-photon emission computed tomography, and subjective effects following the acute administration of salvinorin-A are reported. The study included 2 sub-studies that employed a double-blind, crossover, randomized, placebo-controlled design. The electroencephalography measures showed a marked increase in delta and gamma waves and a decrease in alpha waves while subjects were under the effect of salvinorin-A. Regarding single-photon emission computed tomography measures, significant decreases in regional cerebral blood flow were detected in multiple regions of the frontal, temporal, parietal, and occipital cortices. Significant regional cerebral blood flow increases were observed in some regions of the medial temporal lobe, including the amygdala, the hippocampal gyrus, and the cerebellum. The pattern of subjective effects induced by salvinorin-A was similar to those observed in relation to other psychotomimetic drugs but with an evidently dissociative nature. No dysphoric effects were reported. The salvinorin-A-mediated KOR agonism induced dramatic psychotomimetic effects along with a generalized decrease in cerebral blood flow and electric activity within the cerebral cortex.
Grants:	Agencia Estatal de Investigación DPI2017-83989-R
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	EEG ; Hallucinogens ; Kappa opioid receptor ; Opioids ; Salvinorin-a ; SPECT
Published in:	International journal of neuropsychopharmacology, Vol. 25 (september 2021) , p. 54-63, ISSN 1469-5111

DOI: 10.1093/ijnp/pyab063
PMID: 34537829

10 p, 19.2 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles