Home > Articles > Published articles > Decreased activation of parvalbumin interneurons in the medial prefrontal cortex in intact inbred Roman rats with schizophrenia-like reduced sensorimotor gating |
Date: | 2023 |
Abstract: | Prepulse inhibition (PPI) allows assessing schizophrenia-like sensorimotor gating deficits in rodents. Previous studies indicate that PPI is modulated by the medial prefrontal cortex (mPFC), which is in agreement with our findings showing that PPI differences in the Roman rats are associated with divergences in mPFC activity. Here, we explore whether differences in PPI and mPFC activity in male Roman rats can be explained by (i) differences in the activation (c-Fos) of inhibitory neurons (parvalbumin (PV) interneurons); and/or (ii) reduced excitatory drive (PSD-95) to PV interneurons. Our data show that low PPI in the Roman high-avoidance (RHA) rats is associated with reduced activation of PV interneurons. Moreover, the RHA rats exhibit decreased density of both PV interneurons and PSD-95 puncta on active PV interneurons. These findings point to reduced cortical inhibition as a candidate to explain the schizophrenia-like features observed in RHA rats and support the role of impaired cortical inhibition in schizophrenia. |
Grants: | Agencia Estatal de Investigación PSI2017-82257-P Agencia Estatal de Investigación PID2020-114697GB-I00 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR-1586 Ministerio de Educación, Cultura y Deporte FPU15/06307 Agencia Estatal de Investigación FJC2018-038808-I |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | Parvalbumin ; Prepulse inhibition ; Psd-95 ; Roman rats ; Schizophrenia ; C-fos |
Published in: | Behavioural brain research, Vol. 437 (Feb. 2023) , art. 114113, ISSN 1872-7549 |
5 p, 3.7 MB |