Leukocyte telomere length correlates with hypertrophic cardiomyopathy severity
Chatterjee, Shambhabi (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School)
Gonzalo Calvo, David de (Institut d'Investigació Biomèdica Sant Pau)
Derda, Anselm Arthur (Hannover Medical School. Department of Cardiology and Angiology)
Schimmel, Katharina (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School)
Sonnenschein, Kristina (Hannover Medical School. Department of Cardiology and Angiology)
Bavendiek, Udo (Hannover Medical School. Department of Cardiology and Angiology)
Bauersachs, Johann (REBIRTH Excellence Cluster. Hannover Medical School)
Bär, Christian (Institute of Molecular and Translational Therapeutic Strategies (IMTTS). Hannover Medical School)
Thum, Thomas (National Heart and Lung Institute. Imperial College London)

Data:	2018
Resum:	Telomere length is a marker of biological aging. Short leukocyte telomere length has been associated with various conditions including cardiovascular disorders. Here, we evaluated if patients with hypertrophic cardiomyopathy have altered leukocyte telomere length and whether this is associated with disease severity. A quantitative polymerase chain reaction-based method was used to measure peripheral blood leukocyte telomere length in 59 healthy control subjects and a well-characterized cohort of 88 patients diagnosed with hypertrophic cardiomyopathy: 32 patients with non-obstructive cardiomyopathy (HNCM) and 56 patients with obstructive cardiomyopathy (HOCM). We observed shorter leukocyte telomeres in both HNCM and HOCM patients compared to healthy controls. Furthermore, leukocyte telomere length was inversely associated with HCM even after adjusting for age and sex. Telomere length of HOCM patients was also inversely correlated with left ventricular outflow tract obstruction. Therefore, HOCM patients were categorized by tertiles of telomere length. Patients in the first tertile (shortest telomeres) had a significantly increased left ventricular posterior wall thickness at end-diastole and higher left ventricular outflow tract gradients, whereas the left ventricular end-diastolic diameter was lower compared with patients in the second and third tertile. In summary, telomere length is associated with the severity of the disease in the HOCM subtype.
Ajuts:	Ministerio de Economía y Competitividad IJCI-2016-29393 Instituto de Salud Carlos III CB16/11/00403
Nota:	Altres ajuts: Deutsche Forschungsgemeinschaft (BA5631/2-1); the Hannover Medical School REBIRTH Excellence cluster (KFO311).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adult ; Aged ; Aged, 80 and over ; Cardiomyopathy, Hypertrophic ; Female ; Humans ; Leukocytes ; Male ; Middle Aged ; Severity of Illness Index ; Telomere ; Telomere Homeostasis
Publicat a:	Scientific reports, Vol. 8 Núm. 1 (january 2018) , p. 11227, ISSN 2045-2322

DOI: 10.1038/s41598-018-29072-8
PMID: 30046139

8 p, 1.1 MB

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