Circulating markers of bone turnover
Vervloet, Marc G. (Amsterdam UMC. University Medical Center)
Bover, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Brandenburg, Vincent M. (RWTH University Hospital Aachen (Alemanya))
Covic, Adrian
Cozzolino, Mario
Evenepoel, Pieter
Goldsmith, David
Massy, Ziad
Mazzaferro, Sandro
Ureña-Torres, Pablo
Universitat Autònoma de Barcelona

Fecha:	2017
Resumen:	Renal osteodystrophy is a feature of chronic kidney disease (CKD), with increasing prevalence as CKD progresses. This bone disease is responsible for major morbidity, including fractures, and a deterioration in the quality of life and its sequelae. Circulating biomarkers of renal osteodystrophy typically indicate bone turnover, but not other features of bone, like bone volume, mineralization, quality or strength. Bone turnover can be considered to be primarily a reflection of bone cell activity, in particular that of osteoblasts and osteoclasts. Since current treatments for bone disease usually target cellular activity, biomarkers are considered to be able to contribute to the decision-making for treatment and its follow-up. In CKD, one has to consider the impact of a diminished clearance of biomarkers or their altered metabolism, both potentially limiting its clinical use. Here, several aspects of the most frequently used biomarkers of bone turnover are reviewed, with an emphasis on the specific situation represented by CKD. This review is based on the overview lecture at the symposium held in Amsterdam, September 23, 2016: "The Bone In CKD", organized by the CKD-MBD working group of ERA-EDTA.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Ressenya ; recerca ; Versió publicada
Materia:	Biomarkers ; Bone turnover ; CKD-MBD ; Chronic kidney disease
Publicado en:	Journal of Nephrology, Vol. 30 Núm. 5 (january 2017) , p. 663-670, ISSN 1724-6059

DOI: 10.1007/s40620-017-0408-8
PMID: 28502032

8 p, 798.4 KB

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