Malignant bone tumors (other than Ewing's) : clinical practice guidelines for diagnosis, treatment and follow-up by Spanish Group for Research on Sarcomas (GEIS)
Redondo, Andrés (Hospital Universitario La Paz (Madrid))
Bagué Rosell, Sílvia (Institut d'Investigació Biomèdica Sant Pau)
Bernabeu, Daniel (Hospital Universitario La Paz (Madrid))
Ortiz-Cruz, Eduardo (Hospital Universitario La Paz (Madrid))
Valverde, Claudia (Hospital Universitari Vall d'Hebron)
Alvarez, Rosa (Hospital General Universitario Gregorio Marañón)
Martínez-Trufero, Javier (Hospital Universitario Miguel Servet (Saragossa))
Lopez-Martin, Jose A. (Hospital 12 de Octubre (Madrid))
Correa, Raquel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Cruz, Josefina (Hospital Universitario de Canarias (La Laguna))
López Pousa, Antonio (Institut d'Investigació Biomèdica Sant Pau)
Santos, Aurelio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
García del Muro, Xavier (Institut Catalá d'Oncologia Hospitalet)
Martin-Broto, Javier (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Universitat Autònoma de Barcelona

Data:	2017
Resum:	Primary malignant bone tumors are uncommon and heterogeneous malignancies. This document is a guideline developed by the Spanish Group for Research on Sarcoma with the participation of different specialists involved in the diagnosis and treatment of bone sarcomas. The aim is to provide practical recommendations with the intention of helping in the clinical decision-making process. The diagnosis and treatment of bone tumors requires a multidisciplinary approach, involving as a minimum pathologists, radiologists, surgeons, and radiation and medical oncologists. Early referral to a specialist center could improve patients' survival. The multidisciplinary management of osteosarcoma, chondrosarcoma, chordoma, giant cell tumor of bone and other rare bone tumors is reviewed in this guideline. Ewing's sarcoma will be the focus of a separate guideline because of its specific biological, clinical and therapeutic features. Each statement has been accompanied by the level of evidence and grade of recommendation on the basis of the available data. Surgical excision is the mainstay of treatment of a localized bone tumor, with various techniques available depending on the histologic type, grade and location of the tumor. Chemotherapy plays an important role in some chemosensitive subtypes (such as high-grade osteosarcoma). In other subtypes, historically considered chemoresistant (such as chordoma or giant cell tumor of bone), new targeted therapies have emerged recently, with a very significant efficacy in the case of denosumab. Radiation therapy is usually necessary in the treatment of chordoma and sometimes of other bone tumors.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bone tumors ; Bone sarcomas ; Clinical guideline ; Diagnosis ; Treatment
Publicat a:	Cancer Chemotherapy and Pharmacology, Vol. 80 Núm. 6 (january 2017) , p. 1113-1131, ISSN 1432-0843

DOI: 10.1007/s00280-017-3436-0
PMID: 29038849

19 p, 837.6 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
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