Childhood and Adolescent Central Nervous System Tumours in Spain : Incidence and Survival over 20 Years: A Historical Baseline for Current Assessment
Chirlaque, María D. (Universidad de Murcia. Departamento de Epidemiología)
Peris-Bonet, Rafael (Spanish Registry of Childhood Tumours. University of Valencia)
Sánchez, Antonia (Department of Epidemiology. Murcia Regional Health Authority)
Cruz, Ofelia (Hospital Sant Joan de Déu (Manresa))
Marcos-Gragera, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Gutiérrez-Ávila, Gonzalo (Castile-La Mancha Cancer Registry)
Quirós-García, José R. (Asturias Cancer Registry. Public Health Directorate)
Almela-Vich, Fernando (Valencian Regional Childhood Cancer Registry)
López de Munain, Arantza (Basque Country Cancer Registry)
Sánchez, María J. (Granada Bio-Health Research Institute)
Franch-Sureda, Paula (Mallorca Cancer Registry. Balearic Isles Health Research Institute)
Ardanaz, Eva (Navarre Health Research Institute)
Galceran, Jaume (Universitat Rovira i Virgili)
Martos, Carmen (Foundation for the Promotion of Health and Biomedical Research in the Valencian Region)
Salmerón, Diego (Universidad de Murcia. Department of Health and Social Sciences)
Gatta, Gemma (Fondazione IRCCS Istituto Nazionale dei Tumori di Milano)
Botta, Laura (Istituto Nazionale dei Tumori)
Cañete, Adela (Universitat de València)

Data:	2023
Resum:	Background: Central nervous system (CNS) neoplasms are highly frequent solid tumours in children and adolescents. While some studies have shown a rise in their incidence in Europe, others have not. Survival remains limited. We addressed two questions about these tumours in Spain: (1) Is incidence increasing? and (2) Has survival improved? Methods: This population-based study included 1635 children and 328 adolescents from 11 population-based cancer registries with International Classification of Childhood Cancer Group III tumours, incident in 1983-2007. Age-specific and age-standardised (world population) incidence rates (ASRws) were calculated. Incidence time trends were characterised using annual percent change (APC) obtained with Joinpoint. Cases from 1991 to 2005 (1171) were included in Kaplan-Meier survival analyses, and the results were evaluated with log-rank and log-rank for trend tests. Children's survival was age-standardised using: (1) the age distribution of cases and the corresponding trends assessed with Joinpoint; and (2) European weights for comparison with Europe. Results: ASRw 1983-2007: children: 32. 7 cases/10; adolescents: 23. 5 cases/10. The overall incidence of all tumours increased across 1983-2007 in children and adolescents. Considering change points, the APCs were: (1) children: 1983-1993, 4. 3%^ (1. 1; 7. 7); 1993-2007, −0. 2% (−1. 9; 1. 6); (2) adolescents: 1983-2004: 2. 9%^ (0. 9; 4. 9); 2004-2007: −7. 7% (−40; 41. 9). For malignant tumours, the trends were not significant. 5-year survival was 65% (1991-2005), with no significant trends (except for non-malignant tumours). Conclusions: CNS tumour incidence in Spain was found to be similar to that in Europe. Rises in incidence may be mostly attributable to changes in the registration of non-malignant tumours. The overall malignant CNS tumour trend was compatible with reports for Southern Europe. Survival was lower than in Europe, without improvement over time. We provide a baseline for assessing current paediatric oncology achievements and incidence in respect of childhood and adolescent CNS tumours.
Ajuts:	Instituto de Salud Carlos III RD06/0020/1021 Ministerio de Sanidad y Consumo RD06/0020/0089 Instituto de Salud Carlos III PI061742
Nota:	This work is part of the PITTI project, which was funded by the Carlos III Institute of Health (Health Research Fund/Fondo de Investigación Sanitaria) (ISCIII2006_PI061742); RTICC RD 06/0020/1021; RTICC RD06/0020/0089.
Nota:	The Spanish Childhood Cancer Registry (RETI-SEHOP) is supported by collaboration between Spain's Ministry of Health, the Spanish Society of Paediatric Haematology and Oncology (SEHOP), and the University of Valencia, for whose support we are most grateful. We should also like to thank the Enriqueta Villavecchia Foundation and the Federación Española de Padres de Niños con Cáncer, as well as all the cancer registry staff who work so unstintingly to enable data to be collected on childhood cancer in Spain.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Childhood CNS tumours ; Adolescent CNS tumours ; Incidence ; Survival ; Time trends ; Paediatric oncology ; Population-based cancer registries ; Spain
Publicat a:	Cancers, Vol. 15 Núm. 24 (december 2023) , p. 5889, ISSN 2072-6694

DOI: 10.3390/cancers15245889
PMID: 38136432

32 p, 5.0 MB

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