Bias in dissemination of clinical research findings : Structured OPEN framework of what, who and why, based on literature review and expert consensus
Bassler, Dirk (University Hospital Zurich (Suïssa))
Mueller, Katharina F. (University Children's Hospital Tuebingen)
Briel, Matthias (University Hospital Basel (Basilea, Suïssa))
Kleijnen, Jos (Maastricht University)
Marusic, Ana (University of Split)
Wager, Elizabeth (Sideview)
Antes, Gerd (University of Freiburg)
Von Elm, Erik (Lausanne University Hospital)
Altman, Douglas G. (University of Oxford)
Meerpohl, Joerg J. (University of Freiburg)
Bertelè, Vittorio (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri)
Bonfill, Xavier (Institut d'Investigació Biomèdica Sant Pau)
Bouesseau, Marie-Charlotte (WHO)
Boutron, Isabelle (Paris Descartes University)
Gallus, Silvano (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri)
Garattini, Silvio (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri)
Ghersi, Davina (University of Sydney)
Karam, Ghassan (World Health Organization)
Kulig, Michael (Federal Joint Committee)
La Vecchia, Carlo (University of Milan)
Littmann, Jasper (Hannover Medical Scholl)
Malički, Mario (University of Split)
Murisic, Bojana (IRCCS-Istituto di Ricerche Farmacologiche Mario Negri)
Nolting, Alexandra (Federal Joint Committee)
Pardo-Hernandez, Hector (Institut d'Investigació Biomèdica Sant Pau)
Perleth, Matthias (Federal Joint Committee)
Ravaud, Philippe (Paris Descartes University)
Reis, Andreas (World Health Organization)
Schell, Lisa (University of Freiburg)
Schmucker, Christine (University of Freiburg)
Schwarzer, Guido (University of Freiburg)
Strech, Daniel (Hannover Medical Scholl)
Trinquart, Ludovic (Paris Descartes University)
Urrútia, Gerard (Institut d'Investigació Biomèdica Sant Pau)
Wolff, Robert (Kleijnen Systematic Reviews Ltd)
Universitat Autònoma de Barcelona

Date:	2016
Abstract:	The aim of this study is to review highly cited articles that focus on non-publication of studies, and to develop a consistent and comprehensive approach to defining (non-) dissemination of research findings. Setting: We performed a scoping review of definitions of the term 'publication bias' in highly cited publications. Ideas and experiences of a core group of authors were collected in a draft document, which was complemented by the findings from our literature search. The draft document including findings from the literature search was circulated to an international group of experts and revised until no additional ideas emerged and consensus was reached. We propose a new approach to the comprehensive conceptualisation of (non-) dissemination of research. Secondary outcomes: Our 'What, Who and Why?' approach includes issues that need to be considered when disseminating research findings (What?), the different players who should assume responsibility during the various stages of conducting a clinical trial and disseminating clinical trial documents (Who?), and motivations that might lead the various players to disseminate findings selectively, thereby introducing bias in the dissemination process (Why?). Our comprehensive framework of (non-) dissemination of research findings, based on the results of a scoping literature search and expert consensus will facilitate the development of future policies and guidelines regarding the multifaceted issue of selective publication, historically referred to as 'publication bias'.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Dissemination bias ; MEDICAL ETHICS ; OPEN Project ; Publication Bias ; QUALITATIVE RESEARCH
Published in:	BMJ open, Vol. 6 Núm. 1 (2016) , p. e010024, ISSN 2044-6055

DOI: 10.1136/bmjopen-2015-010024
PMID: 26801469

8 p, 775.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles