Bioinspired phenol-based coatings for medical fabrics against antimicrobial resistance
Bolaños Cardet, Jose Daniel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Ruiz-Molina, Daniel (Institut Català de Nanociència i Nanotecnologia)
Yuste Mateos, Víctor José (Universitat Autònoma de Barcelona. Institut de Neurociències)
Suárez García, Salvio (Institut Català de Nanociència i Nanotecnologia)

Date:	2024
Abstract:	Multi-resistant pathogens can cause several nosocomial infections that can harm hospital interventions or undermine biological processes. In this scenario, the development of novel and efficient antimicrobial materials is essential for reducing pathogen spread. Though many approaches have been followed with this aim, scalability, safety, and efficiency concerns still hamper their clinical transfer. In this work, we overcome these limitations by co-polymerizing phenolic derivatives with amino-terminal ligands. The resulting coatings are successfully applied to woven and non-woven-based materials used in healthcare: paper, cotton and polypropylene. Moreover, the coatings demonstrate multi-pathway antimicrobial activity against six bacteria (E. coli, P. aeruginosa, S. aureus, methicillin-resistant S. aureus, E. faecalis, and B. subtilis) and two fungi (C. albicans and C. auris), a fact attributed to i) reactive oxygen species generation over time and ii) protic amino groups exposed on the surface. After 180 min, viable bacteria are reduced by more than 99. 9 %, with a comparable decline in fungi after 24 h. As a proof-of-concept, coated commercial band-aids tested on skin ex vivo reduced bacterial growth by about 90 %. Considering these results and long-lasting, in vitro biocompatibility, scalability and eco-friendly technology, these coatings represent a promising alternative to be applied in healthcare environments, avoiding pathogen spread, infections and antimicrobial resistance.
Grants:	Agencia Estatal de Investigación PID2021-127983OB-C21 Agencia Estatal de Investigación CEX2021-001214-S Agencia Estatal de Investigación SAF2017-83206-R
Note:	Altres ajuts: acords transformatius de la UAB
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bioinspired ; Catechol ; Coatings ; Multi-resistant bacteria ; Antimicrobial ; Healthcare
Published in:	Chemical engineering journal, Vol. 481 (February 2024) , art. 148674, ISSN 1873-3212

DOI: 10.1016/j.cej.2024.148674

13 p, 13.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles