Targeting lymphoid-derived IL-17 signaling to delay skin aging
Solá, Paloma (Institute for Research in Biomedicine. Barcelona Institute of Science and Technology)
Mereu, Elisabetta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Bonjoch, Júlia (Institute for Research in Biomedicine. Barcelona Institute of Science and Technology)
Casado Pelaez, Marta (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Prats, Neus (Institute for Research in Biomedicine. Barcelona Institute of Science and Technology)
Aguilera Pujabet, Mònica (Institute for Research in Biomedicine. Barcelona Institute of Science and Technology)
Reina, Oscar (Institute for Research in Biomedicine. Barcelona Institute of Science and Technology)
Blanco, Enrique (Centre for Genomic Regulation. Barcelona Institute of Science and Technology)
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Di Croce, Luciano (Institució Catalana de Recerca i Estudis Avançats)
Heyn, Holger (Centre for Genomic Regulation. Barcelona Institute of Science and Technology)
Solanas, Guiomar (Institute for Research in Biomedicine. Barcelona Institute of Science and Technology)
Benitah, Salvador Aznar (Institució Catalana de Recerca i Estudis Avançats)

Date:	2023
Abstract:	Skin aging is characterized by structural and functional changes that contribute to age-associated frailty. This probably depends on synergy between alterations in the local niche and stem cell-intrinsic changes, underscored by proinflammatory microenvironments that drive pleotropic changes. The nature of these age-associated inflammatory cues, or how they affect tissue aging, is unknown. Based on single-cell RNA sequencing of the dermal compartment of mouse skin, we show a skew towards an IL-17-expressing phenotype of T helper cells, γδ T cells and innate lymphoid cells in aged skin. Importantly, in vivo blockade of IL-17 signaling during aging reduces the proinflammatory state of the skin, delaying the appearance of age-related traits. Mechanistically, aberrant IL-17 signals through NF-κB in epidermal cells to impair homeostatic functions while promoting an inflammatory state. Our results indicate that aged skin shows signs of chronic inflammation and that increased IL-17 signaling could be targeted to prevent age-associated skin ailments.
Grants:	European Commission. Horizon 2020 787041 Agencia Estatal de Investigación RTI2018-094049-B-I00 Agencia Estatal de Investigación SAF2017- 89109-P
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Nature Aging, Vol. 3 Núm. 6 (june 2023) , p. 688-704, ISSN 2662-8465

DOI: 10.1038/s43587-023-00431-z
PMID: 37291218

34 p, 9.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Josep Carreras Leukaemia Research Institute
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