Hopelessness in Patients with Early-Stage Relapsing-Remitting Multiple Sclerosis
Sainz de la Maza, Susana (Hospital Universitario Ramón y Cajal)
Maurino, Jorge (Roche Farma)
Castillo-Triviño, Tamara (Hospital Universitario Donostia)
Borges, Mónica (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Sebastián Torres, Berta (Hospital Universitario Miguel Servet)
Sotoca Fernández, Javier (Hospital Universitari Vall d'Hebron)
Alonso Torres, Ana María (Hospital Regional Universitario de Málaga)
Caminero, Ana B (Complejo Asistencial de Ávila)
Borrega, Laura (Hospital Universitario Fundación Alcorcón)
Sánchez-Menoyo, José L (Hospital de Galdakao (Usansolo, Biscaia))
Barrero-Hernández, Francisco J (D Hospital Universitario Clínico San Cecilio)
Calles, Carmen (Hospital Universitari Son Espases)
Brieva Ruiz, Luis (Hospital Arnau de Vilanova (Lleida, Catalunya))
Blasco, María Rosario (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Dotor García-Soto, Julio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Rodríguez-Regal, Ana (Complejo Hospitalario Universitario de Pontevedra)
Navarro-Cantó, Laura (Hospital General Universitario de Elche)
Agüera-Morales, Eduardo (Hospital Universitario Reina Sofía)
Garcés, Moisés (Hospital Clínico Universitario Lozano Blesa)
Carmona, Olga (Fundació Salut Empordà)
Gabaldón-Torres, Laura (Hospital Francesc de Borja)
Forero, Lucía (Hospital Universitario Puerta del Mar)
Hervás, Mariona (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Gómez-Ballesteros, Rocío (Roche Farma)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Hopelessness is a risk factor for depression and suicide. There is little information on this phenomenon among patients with relapsing-remitting multiple sclerosis (RRMS), one of the most common causes of disability and loss of autonomy in young adults. The aim of this study was to assess state hopelessness and its associated factors in early-stage RRMS. A multicenter, non-interventional study was conducted. Adult patients with a diagnosis of RRMS, a disease duration ≤ 3 years, and an Expanded Disability Status Scale (EDSS) score of 0-5. 5 were included. The State-Trait Hopelessness Scale (STHS) was used to measure patients' hopelessness. A battery of patient-reported and clinician-rated measurements was used to assess clinical status. A multivariate logistic regression analysis was conducted to determine the association between patients' characteristics and state hopelessness. A total of 189 patients were included. Mean age (standard deviation-SD) was 36. 1 (9. 4) years and 71. 4% were female. Median disease duration (interquartile range-IQR) was 1. 4 (0. 7, 2. 1) years. Symptom severity and disability were low with a median EDSS (IQR) score of 1. 0 (0, 2. 0). A proportion of 65. 6% (n=124) of patients reported moderate-to-severe hopelessness. Hopelessness was associated with older age (p=0. 035), depressive symptoms (p=<0. 001), a threatening illness perception (p=0. 001), and psychological and cognitive barriers to workplace performance (p=0. 029) in the multivariate analysis after adjustment for confounders. Hopelessness was a common phenomenon in early-stage RRMS, even in a population with low physical disability. Identifying factors associated with hopelessness may be critical for implementing preventive strategies helping patients to adapt to the new situation and cope with the disease in the long term.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Depressive symptoms ; Hopelessness ; Relapsing-remitting multiple sclerosis ; Suicide ; Workplace difficulties
Publicat a:	Patient preference and adherence, Vol. 17 (june 2023) , p. 1431-1439, ISSN 1177-889X

DOI: 10.2147/PPA.S411069
PMID: 37337517

9 p, 439.7 KB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d’Investigació i Innovació Parc Taulí (I3PT)
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