Classification of suicidal thoughts and behaviour in children : results from penalised logistic regression analyses in the Adolescent Brain Cognitive Development study
Van Velzen, L.S. (University of Melbourne)
Toenders, Y.J. (Orygen)
Avila-Parcet, Aina (Institut d'Investigació Biomèdica Sant Pau)
Dinga, R. (Radboud University)
Rabinowitz, J.A. (Johns Hopkins University)
Campos, A.I. (The University of Queensland)
Jahanshad, N. (University of Southern California)
Rentería, M.E. (The University of Queensland)
Schmaal, L. (Orygen)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Despite efforts to predict suicide risk in children, the ability to reliably identify who will engage in suicide thoughts or behaviours has remained unsuccessful. Aims We apply a novel machine-learning approach and examine whether children with suicide thoughts or behaviours could be differentiated from children without suicide thoughts or behaviours based on a combination of traditional (sociodemographic, physical health, social-environmental, clinical psychiatric) risk factors, but also more novel risk factors (cognitive, neuroimaging and genetic characteristics). The study included 5885 unrelated children (50% female, 67% White, 9-11 years of age) from the Adolescent Brain Cognitive Development (ABCD) study. We performed penalised logistic regression analysis to distinguish between: (a) children with current or past suicide thoughts or behaviours; (b) children with a mental illness but no suicide thoughts or behaviours (clinical controls); and (c) healthy control children (no suicide thoughts or behaviours and no history of mental illness). The model was subsequently validated with data from seven independent sites involved in the ABCD study (n = 1712). Our results showed that we were able to distinguish the suicide thoughts or behaviours group from healthy controls (area under the receiver operating characteristics curve: 0. 80 child-report, 0. 81 for parent-report) and clinical controls (0. 71 child-report and 0. 76-0. 77 parent-report). However, we could not distinguish children with suicidal ideation from those who attempted suicide (AUROC: 0. 55-0. 58 child-report; 0. 49-0. 53 parent-report). The factors that differentiated the suicide thoughts or behaviours group from the clinical control group included family conflict, prodromal psychosis symptoms, impulsivity, depression severity and history of mental health treatment. This work highlights that mostly clinical psychiatric factors were able to distinguish children with suicide thoughts or behaviours from children without suicide thoughts or behaviours. Future research is needed to determine if these variables prospectively predict subsequent suicidal behaviour.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Children ; Machine learning ; Penalised logistic regression ; Suicide ; Youth
Published in:	The British journal of psychiatry, Vol. 220 Núm. 4 (february 2022) , p. 210-218, ISSN 1472-1465

DOI: 10.1192/bjp.2022.7
PMID: 35135639

9 p, 484.1 KB

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Articles > Research articles
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