PCSK9 plasma concentration is associated with epicardial adipose tissue volume and metabolic control in patients with type 1 diabetes
Sardà, Helena (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Colom, Cristina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Benitez, Sonia (Institut de Recerca Sant Pau)
Carreras, Gemma (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Amigó, Judit (Hospital Universitari Vall d'Hebron)
Miñambres, Inka (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Viladés Medel, David (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Blanco Vaca, Francisco (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Sanchez-Quesada, Jose Luis (Institut de Recerca Sant Pau)
Pérez Pérez, Antonio (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Date:	2024
Abstract:	Patients with type 1 diabetes (T1D) have a greater risk of cardiovascular disease. Proconvertase subtilisin-kexin 9 (PCSK9) is involved in the atherosclerosis process. This study aimed to determine the relationship between PCSK9 levels and epicardial adipose tissue (EAT) volume and cardiometabolic variables in patients with T1D. This was an observational cross-sectional study including 73 patients with T1D. Clinical, biochemical and imaging data were collected. We divided the patients into two groups according to their glycemic control and the EAT index (iEAT) percentile. We performed a correlation analysis between the collected variables and PCSK9 levels; subsequently, we performed a multiple regression analysis with the significant parameters. The mean age was 47. 6 ± 8. 5 years, 58. 9% were men, and the BMI was 26. 9 ± 4. 6 kg/m 2. A total of 31. 5%, 49. 3% and 34. 2% of patients had hypertension, dyslipidemia and smoking habit, respectively. The PCSK9 concentration was 0. 37 ± 0. 12 mg/L, which was greater in patients with worse glycemic control (HbA1c > 7. 5%), dyslipidemia and high EAT volume (iEAT > 75th percentile). The PCSK9 concentration was positively correlated with age (r = 0. 259; p = 0. 027), HbA1c (r = 0. 300; p = 0. 011), insulin dose (r = 0. 275; p = 0. 020), VLDL-C level (r = 0. 331; p = 0. 004), TG level (r = 0. 328; p = 0. 005), and iEAT (r = 0. 438; p < 0. 001). Multiple regression analysis revealed that 25% of the PCSK9 variability was explained by iEAT and HbA1c (p < 0. 05). The PCSK9 concentration is associated with metabolic syndrome parameters, poor glycemic control and increased EAT volume in patients with T1D.
Grants:	Ministerio de Economía y Competitividad PI16/00471 Instituto de Salud Carlos III PI20/00334
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biomarkers ; Cardiometabolic risk factors ; Cardiometabolic traits ; Cardiovascular disease risk ; Endocrine system and metabolic diseases ; Endocrinology ; Epicardial adipose tissue ; Medical research ; Type 1 diabetes
Published in:	Scientific reports, Vol. 14 (march 2024) , ISSN 2045-2322

DOI: 10.1038/s41598-024-57708-5
PMID: 38532033

8 p, 973.9 KB

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