Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode
Segura, Alex G. (Universitat de Barcelona)
Mezquida, Gisela (Hospital Clínic i Provincial de Barcelona)
Martínez Piñeiro, Alberto (Universitat de Barcelona)
Gassó, Patricia (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Rodriguez, Natalia (Universitat de Barcelona)
Moreno-Izco, Lucía (Instituto de Investigación Sanitaria de Navarra)
Amoretti, Silvia (Hospital Clínic i Provincial de Barcelona)
Bioque, Miquel (Hospital Clínic i Provincial de Barcelona)
Lobo, Antonio (Instituto de Investigación Sanitaria Aragón)
González-Pinto, Ana (Arabako Unibertsitate Ospitalea (Vitoria, País Basc))
García-Alcon, Alicia (Hospital General Universitario Gregorio Marañón)
Roldán-Bejarano, Alexandra (Institut d'Investigació Biomèdica Sant Pau)
Vieta, Eduard (Universitat de Barcelona)
de la Serna, Elena (Universitat de Barcelona)
Toll, Alba (Institut Hospital del Mar d'Investigacions Mèdiques)
Cuesta, Manuel J (Instituto de Investigación Sanitaria de Navarra)
Mas, Sergi (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Bernardo, Miquel (Universitat de Barcelona)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Clinical intervention in early stages of psychotic disorders is crucial for the prevention of severe symptomatology trajectories and poor outcomes. Genetic variability is studied as a promising modulator of prognosis, thus novel approaches considering the polygenic nature of these complex phenotypes are required to unravel the mechanisms underlying the early progression of the disorder. The sample comprised of 233 first-episode psychosis (FEP) subjects with clinical and cognitive data assessed periodically for a 2-year period and 150 matched controls. Polygenic risk scores (PRSs) for schizophrenia, bipolar disorder, depression, education attainment and cognitive performance were used to assess the genetic risk of FEP and to characterize their association with premorbid, baseline and progression of clinical and cognitive status. Schizophrenia, bipolar disorder and cognitive performance PRSs were associated with an increased risk of FEP [false discovery rate (FDR) ⩽ 0. 027]. In FEP patients, increased cognitive PRSs were found for FEP patients with more cognitive reserve (FDR ⩽ 0. 037). PRSs reflecting a genetic liability for improved cognition were associated with a better course of symptoms, functionality and working memory (FDR ⩽ 0. 039). Moreover, the PRS of depression was associated with a worse trajectory of the executive function and the general cognitive status (FDR ⩽ 0. 001). Our study provides novel evidence of the polygenic bases of psychosis and its clinical manifestation in its first stage. The consistent effect of cognitive PRSs on the early clinical progression suggests that the mechanisms underlying the psychotic episode and its severity could be partially independent.
Grants:	Ministerio de Ciencia e Innovación PI11/00325 Instituto de Salud Carlos III PI18/01055 Ministerio de Economía y Competitividad PI14/00612
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Cognition ; Early stages ; First-episode psychosis ; Genetics ; Polygenic risk score ; Schizophrenia
Published in:	Psychological Medicine, Vol. 53 (july 2023) , p. 4634-4647, ISSN 1469-8978

DOI: 10.1017/S0033291722001544
PMID: 35678455

14 p, 348.2 KB

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