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1.
19 p, 1.2 MB Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer / Liu, Junke (University of Science and Technology, Wuhan, China) ; Zhang, Zongyong (University of Science and Technology, Wuhan, China) ; Moreno-Delgado, David (Université de Montpellier, France) ; Dalton, James A. R (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rovira, Xavier (Université de Montpellier, France) ; Trapero, Ana (Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona) ; Goudet, Cyril (Université de Montpellier, France) ; Llebaria, Amadeu (Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Yuan, Qilin (University of Science and Technology, Wuhan, China) ; Rondard, Philippe (Université de Montpellier, France) ; Huang, Siluo (University of Science and Technology, Wuhan, China) ; Liu, Jianfeng (University of Science and Technology, Wuhan, China) ; Pin, Jean-Philippe (Université de Montpellier, France) ; Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i de Medicina Preventiva i Salut Pública
GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. [...]
2017 - 10.7554/eLife.26985
eLife, Vol. 6 (august 2017)  
Registre complet - Creative Commons
2.
33 p, 2.5 MB UP-DOWN cortical dynamics reflect state transitions in a bistable network / Jercog, Daniel (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; Roxin, Alex (Centre de Recerca Matemàtica) ; Barthó, Peter (MTA TTK NAP B. Research Group of Sleep Oscillations) ; Luczak, Artur (University of Lethbridge. Canadian Center for Behavioural Neuroscience) ; Compte, Albert (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ; de la Rocha, Jaime (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
In the idling brain, neuronal circuits transition between periods of sustained firing (UP state) and quiescence (DOWN state), a pattern the mechanisms of which remain unclear. Here we analyzed spontaneous cortical population activity from anesthetized rats and found that UP and DOWN durations were highly variable and that population rates showed no significant decay during UP periods. [...]
2017 - 10.7554/eLife.22425
eLife, Vol. 6 (August 2017) , art. e22425  
Registre complet - Creative Commons

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