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20 p, 2.8 MB |
The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways
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Gómez-Marín, Elena (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Posavec-Marjanović, Melanija (Institut Germans Trias i Pujol) ;
Zarzuela, Laura (Cell Dynamics and Signaling Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Basurto-Cayuela, Laura (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Guerrero-Martínez, José A. (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Arribas, Gonzalo (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Yerbes, Rosario (Cell Dynamics and Signaling Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Ceballos-Chávez, María (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Rodríguez-Paredes, Manuel (Institute of Toxicology. University Medical Center Mainz. Johannes Gutenberg University) ;
Tomé, Mercedes (Cell Dynamics and Signaling Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Durán, Raúl V. (Cell Dynamics and Signaling Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO)) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Reyes, José C. (Genome Biology Department. Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER. Consejo Superior de Investigaciones Científicas (CSIC). Universidad de Sevilla (USE). Universidad Pablo de Olavide (UPO))
High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation and cell proliferation. The protein HMG20A is predicted by the AlphaFold2 software to contain three distinct structural elements, which we have functionally characterized: i) an amino-terminal, intrinsically disordered domain with transactivation activity; ii) an HMG box with higher binding affinity for double-stranded, four-way-junction DNA than for linear DNA; and iii) a long coiled-coil domain. [...]
2022 -  10.1093/nar/gkac766
Nucleic acids research, Vol. 50 Núm. 17 (january 2022) , p. 9838-9857
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10 p, 1.1 MB |
Histone Variants and Their Chaperones in Hematological Malignancies
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Kirkiz, Ecem (University of Veterinary Medicine, Vienna, Austria) ;
Meers, Oliver (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Grebien, Florian (University of Veterinary Medicine, Vienna, Austria) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins. While canonical histone proteins are incorporated into chromatin through a replication-coupled process, structural variants of histones, commonly named histone variants, are deposited into chromatin in a replication-independent manner. [...]
2023 - 10.1097/HS9.0000000000000927
HemaSphere, Vol. 7 Núm. 8 (july 2023)
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29 p, 18.3 MB |
The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A
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Mandemaker, Imke K. (Hubrecht Institute) ;
Fessler, Evelyn (Gene Center and Department of Biochemistry. LMU Munich) ;
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Kotthoff, Christiane (Biomedical Center (BMC). Department of Physiological Chemistry. Faculty of Medicine. LMU Munich) ;
Wegerer, Andreas (Biomedical Center (BMC). Department of Physiological Chemistry. Faculty of Medicine. LMU Munich) ;
Rouillon, Clément (Hubrecht Institute) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Jae, Lucas T. (Gene Center and Department of Biochemistry. LMU Munich) ;
Mattiroli, Francesca (Hubrecht Institute) ;
Ladurner, A.G. (Eisbach Bio GmbH)
All vertebrate genomes encode for three large histone H2A variants that have an additional metabolite-binding globular macrodomain module, macroH2A. MacroH2A variants impact heterochromatin organization and transcription regulation and establish a barrier for cellular reprogramming. [...]
2023 - 10.1016/j.celrep.2023.113300
Cell reports, Vol. 42 Núm. 10 (31 2023) , p. 113300
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14 p, 4.6 MB |
Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors
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Lassi, Maximilian (German Center for Diabetes Research (DZD)) ;
Tomar, Archana (German Center for Diabetes Research (DZD)) ;
Comas-Armangué, Gemma (German Center for Diabetes Research (DZD)) ;
Vogtmann, Rebekka (University Hospital Essen. Department of Gynecology and Obstetrics) ;
Dijkstra, Dorieke J. (University of Groningen. Department of Obstetrics and Gynecology) ;
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gerlini, Raffaelle (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Darr, Jonatan (German Center for Diabetes Research (DZD)) ;
Scheid, Fabienne (German Center for Diabetes Research (DZD)) ;
Rozman, Jan (Czech Centre for Phenogenomics. Institute of Molecular Genetics of the Czech Academy of Sciences. BIOCEV) ;
Aguilar-Pimentel, Antonio (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Koren, Omry (Azrieli Faculty of Medicine. Bar Ilan University) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fuchs, Helmut (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Marschall, Susan (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
Gailus-Durner, Valerie (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ;
De Angelis, Martin Hrabe (Technische Universität München. School of Life Science Weihenstephan) ;
Plösch, Torsten (University of Groningen. Department of Obstetrics and Gynecology) ;
Gellhaus, Alexandra (Department of Gynecology and Obstetrics. University Hospital Essen) ;
Teperino, Raffaele (German Center for Diabetes Research (DZD))
Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. [...]
2021 - 10.1126/sciadv.abg6424
Science advances, Vol. 7 Núm. 22 (may 2021) , p. eabg6424
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21 p, 3.3 MB |
The histone variant macroh2a1 impacts circadian gene expression and cell phenotype in an in vitro model of hepatocellular carcinoma
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Carbone, Annalucia (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
De Santis, Elisabetta (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Cela, Olga (University of Foggia) ;
Giambra, Vincenzo (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Miele, Luca (Catholic University of the Sacred Heart) ;
Marrone, Giuseppe (Catholic University of the Sacred Heart) ;
Grieco, Antonio (Catholic University of the Sacred Heart) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Capitanio, Nazzareno (University of Foggia) ;
Mazza, Tommaso (Fondazione IRCCS Casa Sollievo della Sofferenza) ;
Mazzoccoli, Gianluigi (Fondazione IRCCS Casa Sollievo della Sofferenza)
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. A foremost risk factor for HCC is obesity/metabolic syndrome-related non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), which is prompted by remarkable changes in transcription patterns of genes enriching metabolic, immune/inflammatory, and circadian pathways. [...]
2021 - 10.3390/biomedicines9081057
Biomedicines, Vol. 9 Núm. 8 (august 2021) , p. 1057
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13 p, 1.2 MB |
Inhibition of CBP synergizes with the RNA-dependent mechanisms of Azacitidine by limiting protein synthesis
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Diesch, Jeannine (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Le Pannérer, Marguerite Marie (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Winkler, René (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Casquero, Raquel (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Muhar, Matthias (Research Institute of Molecular Pathology (IMP). Vienna BioCenter (VBC)) ;
van der Garde, Mark (German Cancer Consortium (DKTK). Partner Site Munich) ;
Maher, Michael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Martínez Herráez, Carolina (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
Bech-Serra, Joan-Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fellner, Michaela (Research Institute of Molecular Pathology (IMP). Vienna BioCenter (VBC)) ;
Rathert, Philipp (University Stuttgart) ;
Brooks, Nigel (CellCentric. Ltd. Chesterford Research Park) ;
Zamora, Lurdes (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gentilella, Antonio (Universitat de Barcelona. Departament de Bioquímica i Fisiologia) ;
De La Torre Gómez, Gisela Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Zuber, Johannes (Medical University of Vienna. Vienna BioCenter (VBC)) ;
Götze, Katharina S. (Technische Universität München) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The nucleotide analogue azacitidine (AZA) is currently the best treatment option for patients with high-risk myelodysplastic syndromes (MDS). However, only half of treated patients respond and of these almost all eventually relapse. [...]
2021 - 10.1038/s41467-021-26258-z
Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 6060
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