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14 p, 4.6 MB Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors / Lassi, Maximilian (German Center for Diabetes Research (DZD)) ; Tomar, Archana (German Center for Diabetes Research (DZD)) ; Comas-Armangué, Gemma (German Center for Diabetes Research (DZD)) ; Vogtmann, Rebekka (University Hospital Essen. Department of Gynecology and Obstetrics) ; Dijkstra, Dorieke J. (University of Groningen. Department of Obstetrics and Gynecology) ; Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gerlini, Raffaelle (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Darr, Jonatan (German Center for Diabetes Research (DZD)) ; Scheid, Fabienne (German Center for Diabetes Research (DZD)) ; Rozman, Jan (Czech Centre for Phenogenomics. Institute of Molecular Genetics of the Czech Academy of Sciences. BIOCEV) ; Aguilar-Pimentel, Antonio (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Koren, Omry (Azrieli Faculty of Medicine. Bar Ilan University) ; Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Fuchs, Helmut (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Marschall, Susan (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; Gailus-Durner, Valerie (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health) ; De Angelis, Martin Hrabe (Technische Universität München. School of Life Science Weihenstephan) ; Plösch, Torsten (University of Groningen. Department of Obstetrics and Gynecology) ; Gellhaus, Alexandra (Department of Gynecology and Obstetrics. University Hospital Essen) ; Teperino, Raffaele (German Center for Diabetes Research (DZD))
Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. [...]
2021 - 10.1126/sciadv.abg6424
Science advances, Vol. 7 Núm. 22 (may 2021) , p. eabg6424  
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