Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors
Lassi, Maximilian (German Center for Diabetes Research (DZD))
Tomar, Archana (German Center for Diabetes Research (DZD))
Comas-Armangué, Gemma (German Center for Diabetes Research (DZD))
Vogtmann, Rebekka (University Hospital Essen. Department of Gynecology and Obstetrics)
Dijkstra, Dorieke J. (University of Groningen. Department of Obstetrics and Gynecology)
Corujo, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Gerlini, Raffaelle (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health)
Darr, Jonatan (German Center for Diabetes Research (DZD))
Scheid, Fabienne (German Center for Diabetes Research (DZD))
Rozman, Jan (Czech Centre for Phenogenomics. Institute of Molecular Genetics of the Czech Academy of Sciences. BIOCEV)
Aguilar-Pimentel, Antonio (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health)
Koren, Omry (Azrieli Faculty of Medicine. Bar Ilan University)
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Fuchs, Helmut (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health)
Marschall, Susan (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health)
Gailus-Durner, Valerie (German Mouse Clinic. Institute of Experimental Genetics. Helmholtz Zentrum München. German Research Center for Environmental Health)
De Angelis, Martin Hrabe (Technische Universität München. School of Life Science Weihenstephan)
Plösch, Torsten (University of Groningen. Department of Obstetrics and Gynecology)
Gellhaus, Alexandra (Department of Gynecology and Obstetrics. University Hospital Essen)
Teperino, Raffaele (German Center for Diabetes Research (DZD))

Data:	2021
Resum:	Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. Less is known about the role of paternal circadian rhythm for offspring health. Here, we disrupted circadian rhythm in male mice by night-restricted feeding and showed that paternal circadian disruption at conception is important for offspring feeding behavior, metabolic health, and oscillatory transcription. Mechanistically, our data suggest that the effect of paternal circadian disruption is not transferred to the offspring via the germ cells but initiated by corticosterone-based parental communication at conception and programmed during in utero development through a state of fetal growth restriction. These findings indicate paternal circadian health at conception as a newly identified determinant of offspring phenotypes.
Ajuts:	Agencia Estatal de Investigación RTI2018-094005-B-I00 Ministerio de Economía y Competitividad PIE16/00011
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Circadian disruptions ; Circadian rhythms ; Disease risks ; Feeding behavior ; Fetal growth restriction ; Germ cells ; Male mouse ; Model organisms ; Animals ; Circadian Rhythm ; Male ; Mice ; Phenotype
Publicat a:	Science advances, Vol. 7 Núm. 22 (may 2021) , p. eabg6424, ISSN 2375-2548

DOI: 10.1126/sciadv.abg6424
PMID: 34039610

14 p, 4.6 MB

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