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25 p, 1.8 MB |
Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response
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Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron) ;
Grau Expósito, Judith (Hospital Universitari Vall d'Hebron) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron) ;
Suanzes, Paula (Hospital Universitari Vall d'Hebron) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Human immunodeficiency virus (HIV) establishes a persistent infection in heterogeneous cell reservoirs, which can be maintained by different mechanisms including cellular proliferation, and represent the main obstacle to curing the infection. [...]
2022 -  10.7554/eLife.78294
eLife, Vol. 11 (may 2022)
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12 p, 957.4 KB |
Delayed diagnosis of tuberculosis in persons living with HIV in Eastern Europe : associated factors and effect on mortality-a multicentre prospective cohort study
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Kraef, Christian (Heidelberg Institute of Global Health. University of Heidelberg) ;
Bentzon, Adrian (CHIP (Centre of Excellence for Health. Immunity and Infections). Rigshospitalet. University of Copenhagen) ;
Panteleev, Alexander (City TB Dispensary) ;
Skrahina, Alena (Republican Scientific and Practical Center for Pulmonology and Tuberculosis) ;
Bolokadze, Natalie (Infectious Diseases. AIDS and Clinical Immunology Research Center) ;
Tetradov, Simona (Dr Victor Babes' Hospital of Tropical and Infectious Diseases. Bucharest AND 'Carol Davila' University of Medicine and Pharmacy) ;
Podlasin, Regina (Wojewodski Szpital Zakanzy/Medical University of Warsaw) ;
Karpov, Igor (Department of Infectious Disease. Belarusian State Medical University) ;
Borodulina, Elena (Samara State Medical University of the Ministry of Healthcare of the Russian Federation) ;
Denisova, Elena (Botkin Hospital of Infectious Disease) ;
Azina, Inga (Riga East University Hospital. Latvian Centre of Infectious Diseases) ;
Lundgren, Jens (CHIP (Centre of Excellence for Health. Immunity and Infections). Rigshospitalet. University of Copenhagen) ;
Johansen, Isik Somuncu (Odense University Hospital (Dinamarca)) ;
Mocroft, Amanda (Centre for Clinical Research. Epidemiology. Modelling and Evaluation (CREME). Institute for Global Health. UCL) ;
Podlekareva, Daria (CHIP (Centre of Excellence for Health. Immunity and Infections). Rigshospitalet. University of Copenhagen) ;
Kirk, Ole (Odense University Hospital (Dinamarca)) ;
Vassilenko, A. ;
Klimuk, D. ;
Kondratenko, O. ;
Zalutskaya, A. ;
Bondarenko, V. ;
Mitsura, V. ;
Kozorez, E. ;
Tumash, O. ;
Suetnov, O. ;
Paduto, D. ;
Iljina, V. ;
Kummik, T. ;
Mshvidobadze, K. ;
Lanchava, N. ;
Goginashvili, L. ;
Mikiashvili, L. ;
Bablishvili, Nino ;
Rozentale, B. ;
Zeltina, I. ;
Janushkevich, I. ;
Caplinskiene, I. ;
Caplinskas, S. ;
Kancauskiene, Z. ;
Wiercinska-Drapalo, A. ;
Thompson, M. ;
Kozlowska, J. ;
Grezesczuk, A. ;
Bura, M. ;
Knysz, B. ;
Inglot, Malgorzata ;
Garlicki, A. ;
Loster, J. ;
uiculescu, D.D. ;
Rakhmanova, A. ;
Panteleev, O. ;
Yakovlev, A. ;
Kozlov, A. ;
Tyukalova, A. ;
Vlasova, Y. ;
rofimov, T.T. ;
Kyselyova, G. ;
Obel, N. ;
Gerstoft, J. ;
Kronborg, G. ;
Payen, M.C. ;
abeya, K.K. ;
Necsoi, C. ;
Dabis, F. ;
Tsaranazy, A. ;
Cazanave, C. ;
Furrer, Hansjakob ;
Sagette, M. ;
Rickenbach, M. ;
Sculier, D. ;
Calmy, Alexandra ;
Cavassini, Matthias ;
Bruno, A. ;
Bernasconi, E. ;
Hoffmann, M. ;
Vernazza, P. ;
Fehr, J. ;
Weber, R. ;
Miller, R. ;
Vora, N. ;
Cooke, G. ;
Mullaney, S. ;
Wilkins, E. ;
George, V. ;
Collini, P. ;
Dockrell, D. ;
Post, F. ;
Campbell, L. ;
Brum, R. ;
Mabonga, E. ;
Saigal, P. ;
Kegg, S. ;
Ainsworth, J. ;
Waters, A. ;
Dhar, J. ;
Ellis, K. ;
Girardi, E. ;
Rianda, A. ;
Galati, V. ;
Pinnetti, C. ;
Tommasi, C. ;
Lapadula, G. ;
Di Biagio, A. ;
Parisini, A. ;
Carbonara, S. ;
Angarano, G. ;
Purgatorio, M. ;
Matteelli, A. ;
Apostoli, A. ;
Miro, J.M. ;
Manzardo, C. ;
Ligero, C. ;
Gonzalez, J. ;
Martinez-Martinez, J.A. ;
Sanchez, F. ;
Knobel Freud, Hernando ;
Salvadó, M. ;
Lopez-Colomes, J.L. ;
Martínez-Lacasa, X. ;
Cuchí, E. ;
Falcó, Vicenç ;
Curran, Adrian ;
Tortola, M.T. ;
Ocaña Rivera, Immaculada ;
Vidal, R. ;
Sambeat, M.A. ;
Pomar, Virginia (Institut d'Investigació Biomèdica Sant Pau) ;
Coll, P. ;
Pozamczer, D. ;
Saumoy, M. ;
Alcaide, Fernando ;
Caylà, Joan A ;
Moreno Camacho, Asunción ;
Millet, Joan-Pau (Institut d'Investigació Biomèdica Sant Pau) ;
Orcau, Àngels (Institut d'Investigació Biomèdica Sant Pau) ;
Fina, L. ;
Romero, A. ;
Roldan, L.L. ;
Iribarren, J.A. ;
Ibarguren, M. ;
Moreno, S. ;
González, A. ;
Miralles, P. ;
Aldámiz-Echevarría, T. ;
Losso, M. ;
Toibaro, J. ;
Gambardella, L. ;
Toibaro, J. ;
Moreno Macias, L. ;
Warley, E. ;
Tavella, S. ;
Garcia Messina, O. ;
Gear, O. ;
Laplume, H. ;
Marson, C. ;
Contarelia, J. ;
Michaan, M. ;
Scapellato, P. ;
Bartoletti, B. ;
Palmero, D. ;
Elias, C. ;
Cortes, C. ;
Crabtree, B. ;
Mosqueda Gomez, J.L. ;
Villanueva, J.A. ;
Gonzalez Hernandez, L.A. ;
Badial, F.
Background: Early diagnosis of tuberculosis (TB) is important to reduce transmission, morbidity and mortality in people living with HIV (PLWH). Methods: PLWH with a diagnosis of TB were enrolled from HIV and TB clinics in Eastern Europe and followed until 24 months. [...]
2021 - 10.1186/s12879-021-06745-w
BMC Infectious diseases, Vol. 21 Núm. 1 (december 2021) , p. 1038
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6 p, 213.7 KB |
Epidemiology and Diagnosis of Tuberculous Lymphadenitis in a Tuberculosis Low-Burden Country
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Salvador, Fernando (Hospital Universitari Vall d'Hebron) ;
Los-Arcos, Ibai (Hospital Universitari Vall d'Hebron) ;
Sánchez-Montalvá, Adrián (Hospital Universitari Vall d'Hebron) ;
Tórtola Fernández, María Teresa (Hospital Universitari Vall d'Hebron) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron) ;
Villar, A. (Hospital Universitari Vall d'Hebron) ;
Saborit, Nuria (Hospital Universitari Vall d'Hebron) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Molina Romero, Israel (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
The aim of this article is to describe epidemiological and clinical data of patients with tuberculous lymphadenitis (TL) and evaluate the yield of the diagnostic techniques employed. Retrospective observational study was performed at the Vall d'Hebron University Hospital, Barcelona, Spain. [...]
2015 - 10.1097/MD.0000000000000509
Medicine, Vol. 94 (january 2015)
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14 p, 278.2 KB |
Multidisciplinary, evidence-based consensus guidelines for human papillomavirus (HPV) vaccination in highrisk populations, Spain, 2016
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Martínez Gómez, Xavier (Hospital Universitari Vall d'Hebron) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron) ;
Campins Martí, Magda (Hospital Universitari Vall d'Hebron) ;
Alemany, Laia (Institut Català d'Oncologia) ;
Rodrigo-Pendás, José Ángel (Hospital Universitari Vall d'Hebron) ;
Borruel, Natalia (Hospital Universitari Vall d'Hebron) ;
Castellsagué, Xavier (Institut Català d'Oncologia) ;
Díaz de Heredia, Cristina (Hospital Universitari Vall d'Hebron) ;
Moraga-Llop, F. A. (Asociación Española de Vacunología) ;
del Pino, M. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Torné, A. (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Universitat Autònoma de Barcelona
Introduction: Although human papillomavirus (HPV) routine vaccination programmes have been implemented around the world and recommendations have been expanded to include other high-risk individuals, current recommendations often differ between countries in Europe, as well as worldwide. [...]
2019 - 10.2807/1560-7917.ES.2019.24.7.1700857
Eurosurveillance, Vol. 24 Núm. 7 (14 2019) , p. 1700857
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23 p, 3.0 MB |
Latency reversal agents affect differently the latent reservoir present in distinct CD4+ t subpopulations
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Grau Expósito, Judith (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Luque-Ballesteros, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribera, Esteban (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torrella Domingo, Adriana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Badía, Rosa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martin-Castillo, Mario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Fernández-Sojo, Jesús (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Meritxell. (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The capacity of the LRAs to perturb the viral reservoir present in distinct subpopulations of cells is currently unknown. [...]
2019 - 10.1371/journal.ppat.1007991
PLOS pathogens, Vol. 15 Núm. 8 (august 2019) , p. e1007991
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15 p, 4.6 MB |
Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab
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Serra-Peinado, Carla (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Grau Expósito, Judith (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Luque-Ballesteros, Laura (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Astorga-Gamaza, Antonio (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Gallego-Rodriguez, Jenny (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Martín Castillo, Mario (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Ribera, Esteban (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Raventós, Berta (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Willekens, Rein (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Torrella Domingo, Adriana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Badía, Rosa (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
García, Felipe (Hospital Clínic i Provincial de Barcelona) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Genescà Ferrer, Meritxell (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron. Institut de Recerca) ;
Universitat Autònoma de Barcelona
The identification of exclusive markers to target HIV-reservoir cells will represent a significant advance in the search for therapies to cure HIV. Here, we identify the B lymphocyte antigen CD20 as a marker for HIV-infected cells in vitro and in vivo. [...]
2019 - 10.1038/s41467-019-11556-4
Nature communications, Vol. 10 Núm. 1 (january 2019) , p. 3705
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18 p, 1.2 MB |
A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4 + T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients
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Grau Expósito, Judith (Hospital Universitari Vall d'Hebron) ;
Serra-Peinado, Carla (Hospital Universitari Vall d'Hebron) ;
Miguel, Lucia (Hospital Universitari Vall d'Hebron) ;
Navarro, Jordi (Hospital Universitari Vall d'Hebron) ;
Curran, Adrian (Hospital Universitari Vall d'Hebron) ;
Burgos, Joaquín (Hospital Universitari Vall d'Hebron) ;
Ocaña Rivera, Immaculada (Hospital Universitari Vall d'Hebron) ;
Ribera, Esteban (Hospital Universitari Vall d'Hebron) ;
Torrella Domingo, Adriana (Hospital Universitari Vall d'Hebron) ;
Planas, Bibiana (Hospital Universitari Vall d'Hebron) ;
Badía, Rosa (Hospital Universitari Vall d'Hebron) ;
Castellvi, Josep (Hospital Universitari Vall d'Hebron) ;
Falcó, Vicenç (Hospital Universitari Vall d'Hebron) ;
Crespo Casal, Manuel (Hospital Universitari Vall d'Hebron) ;
Buzón, Maria José (Hospital Universitari Vall d'Hebron) ;
Universitat Autònoma de Barcelona
Cells that actively transcribe HIV-1 have been defined as the "active viral reservoir" in HIV-infected individuals. However, important technical limitations have precluded the characterization of this specific viral reservoir during both treated and untreated HIV-1 infections. [...]
2017 - 10.1128/mBio.00876-17
mBio, Vol. 8 (july 2017)
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