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1.
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13 p, 1.4 MB |
Pharmacological effects of methylone and MDMA in humans
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Poyatos, Lourdes (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Hladun, Olga (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Núñez-Montero, Melani (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
de la Rosa, Georgina (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Martín, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Barriocanal, Ana María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carabias, Lydia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Kelmendi, Benjamin (Yale University School of Medicine. Department of Psychiatry) ;
Taoussi, Omayema (Università Politecnica delle Marche. Department of Excellence-Biomedical Sciences and Public Health) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche. Department of Excellence-Biomedical Sciences and Public Health) ;
Fonseca, Francina 1972- (Institut de Neuropsiquiatria i Adiccions (Barcelona)) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Pichini, Simona (Istituto Superiore di Sanità. National Centre on Addiction and Doping (Itàlia)) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Methylone is one of the most common synthetic cathinones popularized as a substitute for 3,4-methylenedioxymethamphetamine (MDMA, midomafetamine) owing to its similar effects among users. Both psychostimulants exhibit similar chemistry (i. [...]
2023 -  10.3389/fphar.2023.1122861
Frontiers in Pharmacology, Vol. 14 (february 2023)
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9 p, 1.2 MB |
Disposition of Cannabidiol Metabolites in Serum and Urine from Healthy Individuals Treated with Pharmaceutical Preparations of Medical Cannabis
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Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche, Italy) ;
Pacifici, Roberta (Istituto Superiore di Sanità, Rome, Italy) ;
Mannocchi, Giulio (University of Camerino, Italy) ;
Gottardi, Massimo (Comedical srl, Trento, Italy) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Martin, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Di Trana, Annagiulia (Università Politecnica delle Marche, Ancona, Italy) ;
Pichini, Simona (Istituto Superiore di Sanità, Rome, Italy) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
The use of cannabis flowering tops with standardized amounts of active phytocannabinoids was recently authorized in several countries to treat several painful pathological conditions. The acute pharmacological effects and disposition of Δ-9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors and THC metabolites after oil and decoction administration have been already described. [...]
2020 - 10.3390/ph13120459
Pharmaceuticals, Vol. 13 (december 2020)
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3.
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14 p, 1.5 MB |
Disposition of Phytocannabinoids, Their Acidic Precursors and Their Metabolites in Biological Matrices of Healthy Individuals Treated with Vaporized Medical Cannabis
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Busardo, Francesco Paolo (Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy) ;
Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pacifici, Roberta (National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy) ;
Mannocchi, Giulio (School of Law, University of Camerino, 62032 Camerino, Italy) ;
Gottardi, Massimo (Comedical S.Rl, 38123 Trento, Italy) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Martin, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pichini, Simona (National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Inhalation by vaporization is a useful application mode for medical cannabis. In this study, we present the disposition of Δ9-tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, and their metabolites in serum, oral fluid, and urine together with the acute pharmacological effects in 14 healthy individuals treated with vaporized medical cannabis. [...]
2021 - 10.3390/ph14010059
Pharmaceuticals, Vol. 14 (january 2021)
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4.
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21 p, 893.8 KB |
Oral Administration of Cannabis and Δ-9-tetrahydrocannabinol (THC) Preparations : A Systematic Review
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Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Acevedo, Ana Pilar (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol) ;
Martin, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Siles, Adrià (Institut Germans Trias i Pujol) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche, Ancona) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Background and objective : Changes in cannabis legalization regimes in several countries have influenced the diversification of cannabis use. There is an ever-increasing number of cannabis forms available, which are gaining popularity for both recreational and therapeutic use. [...]
2020 - 10.3390/medicina56060309
Medicina, Vol. 56 (june 2020)
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5.
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12 p, 5.3 MB |
Bovine endometrial MSC : mesenchymal to epithelial transition during luteolysis and tropism to implantation niche for immunomodulation
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Calle Arias, Alexandra (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya). Departamento de Reproducción Animal) ;
López-Martín, Soraya (UAM. Departamento de Biología Molecular) ;
Monguió-Tortajada, Marta (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Borràs i Serres, Francesc Enric (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Yáñez-Mó, María (Instituto de Investigación Hospital Universitario de la Princesa) ;
Ramírez de Paz, Miguel Ángel (Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Espanya). Departamento de Reproducción Animal)
The uterus is a histologically dynamic organ, and the mechanisms coordinating its regeneration during the oestrous cycle and implantation are poorly understood. The aim of this study was to isolate, immortalize and characterize bovine endometrial mesenchymal stem cell (eMSC) lines from different oestrous cycle stages (embryo in the oviduct, embryo in the uterus or absence of embryo) and examine their migratory and immunomodulatory properties in an inflammatory or implantation-like environment, as well as possible changes in cell transdifferentiation. [...]
2019 - 10.1186/s13287-018-1129-1
Stem cell research & therapy, Vol. 10 (january 2019)
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6.
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11 p, 2.5 MB |
A bead-assisted flow cytometry method for the semi-quantitative analysis of Extracellular Vesicles
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Suárez, Henar (Instituto de Investigación Hospital Universitario de la Princesa) ;
Gámez-Valero, Ana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Reyes, Raquel (Centro de Biología Molecular Severo Ochoa) ;
López-Martín, Soraya (Instituto de Investigación Hospital Universitario de la Princesa) ;
Rodríguez, María Josefa (Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas) ;
Carrascosa, José L. (Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Científicas) ;
Cabañas, Carlos (Centro de Biología Molecular Severo Ochoa) ;
Borràs i Serres, Francesc Enric (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Yáñez-Mó, María (Instituto de Investigación Hospital Universitario de la Princesa) ;
Universitat Autònoma de Barcelona
Most experimental approaches commonly employed for the characterization and quantitation of EVs are time consuming, require of specialized instrumentation and often are rather inaccurate. To circumvent the caveats imposed by EV small size, we used general and specific membrane markers in bead assisted flow cytometry, to provide a semi-quantitative measure of EV content in a given sample. [...]
2017 - 10.1038/s41598-017-11249-2
Scientific reports, Vol. 7 (september 2017) , p. 1-11
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7.
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11 p, 1.6 MB |
Bilastine vs. hydroxyzine : occupation of brain histamine H-receptors evaluated by positron emission tomography in healthy volunteers
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Farre, Magi (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez-Mañá, Clara (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Papaseit, Esther (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Menoyo, Esther (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pérez, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Martin, Soraya (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Bullich, Santiago (Molecular Imaging Centre, CRC Corporación) ;
Rojas, Santiago (Molecular Imaging Centre, CRC Corporación) ;
Herance, José Raul (Molecular Imaging Centre, CRC Corporación) ;
Trampal, Carlos (Molecular Imaging Centre, CRC Corporación) ;
Labeaga, Luis (FAES FARMA S.A) ;
Valiente, Román (FAES FARMA S.A) ;
Universitat Autònoma de Barcelona
A close correlation exists between positron emission tomography (PET)-determined histamine H-receptor occupancy (HRO) and the incidence of sedation. Antihistamines with HRO <20% are classified as non-sedating. [...]
2014 - 10.1111/bcp.12421
British Journal of Clinical Pharmacology, Vol. 78 (october 2014) , p. 970-980
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