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1.
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5 p, 154.0 KB |
Synthetic cannabinoids use in a sample of opioid-use disorder patients
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Alías Ferri, María (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Pellegrini, Manuela (National Centre on Istituto Superiore di Sanità (Itàlia)) ;
Marchei, Emilia (Istituto Superiore di Sanità (Itàlia)) ;
Pacifici, Roberta (Istituto Superiore di Sanità (Itàlia)) ;
Rotolo, Maria Concetta (Istituto Superiore di Sanità (Itàlia)) ;
Pichini, Simona (National Istituto Superiore di Sanità (Itàlia)) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Muga, Roberto (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Fonseca, Francina 1972- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torrens, Marta (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Universitat Autònoma de Barcelona
Cannabis is the most widely consumed illegal drug in the world and synthetic cannabinoids are increasingly gaining popularity and replacing traditional cannabis. These substances are a type of new psychoactive substance that mimics the cannabis effects but often are more severe. [...]
2022 -  10.3389/fpsyt.2022.956120
Frontiers in psychiatry, Vol. 13 (august 2022)
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2.
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19 p, 2.3 MB |
Vascular Endothelial Growth Factor as a Potential Biomarker of Neuroinflammation and Frontal Cognitive Impairment in Patients with Alcohol Use Disorder
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Requena-Ocaña, Nerea (Universidad Complutense de Madrid. Departamento de Psicobiología) ;
Flores-Lopez, María (Hospital Regional Universitario de Málaga) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
García-Marchena, Nuria (Institut Germans Trias i Pujol) ;
Ruiz, Juan Jesús (Centro Provincial de Drogodependencias (CPD) de Málaga) ;
Ortega-Pinazo, Jesús (Hospital Regional Universitario de Málaga) ;
Serrano, Antonia (Hospital Regional Universitario de Málaga) ;
Pavón-Morón, Francisco Javier (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Suarez, Juan (Department of Anatomy, Legal Medicine and History of Science, School of Medicine, University of Malaga) ;
Rodríguez de Fonseca, Fernando (Hospital Regional Universitario de Málaga) ;
Araos, Pedro (Universidad de Málaga. Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento)
(1) Background: Alcohol Use Disorder (AUD) is associated with functional disruption of several brain structures that may trigger cognitive dysfunction. One of the mechanisms of alcohol-associated cognitive impairment has been proposed to arise from its direct impact on the immune system, which culminates in the release of cytokines and chemokines which can eventually reach the brain. [...]
2022 - 10.3390/biomedicines10050947
Biomedicines, Vol. 10 (april 2022)
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3.
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15 p, 1.9 MB |
GC-MS/MS Determination of Synthetic Cathinones : 4-chloromethcathinone, N-ethyl Pentedrone, and N-ethyl Hexedrone in Oral Fluid and Sweat of Consumers under Controlled Administration: Pilot Study
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Nuñez-Montero, Melani (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lombroni, Claudia (Univesità degli Studi di Torino) ;
Maida, Nunzia La (Istituto Superiore di Sanità) ;
Rotolo, Maria Concetta (Istituto Superiore di Sanità) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Ventura, Mireia (Associació Benestar i Desenvolupament) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Marchei, Emilia (Istituto Superiore di Sanità) ;
Universitat Autònoma de Barcelona
This study presents a validated GC-MS/MS method for the detection and quantification of 4-chloromethcathinone or clephedrone (4-CMC), N-ethyl Pentedrone (NEP), and N-ethyl Hexedrone (NEH, also named HEXEN) in oral fluid and sweat and verifies its feasibility in determining human oral fluid concentrations and pharmacokinetics following the administration of 100 mg of 4-CMC orally and 30 mg of NEP and NEH intranasally. [...]
2023 - 10.3390/ijms24119387
International journal of molecular sciences, Vol. 24 (may 2023)
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4.
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13 p, 819.4 KB |
Methylone and MDMA Pharmacokinetics Following Controlled Administration in Humans
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Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Lo Faro, Alfredo Fabrizio (Università Politecnica delle Marche) ;
Berardinelli, Diletta (Università Politecnica delle Marche) ;
Sprega, Giorgia (Università Politecnica delle Marche) ;
Malaca, Sara (Università Politecnica delle Marche) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Huestis, Marilyn A. (Thomas Jefferson University) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study is to define, for the first time, human methylone and HMMC plasma pharmacokinetics following controlled administration of 50-200 mg methylone to 12 male volunteers. A new LC-MS/MS method was validated to quantify methylone, MDMA, and their metabolites in plasma. [...]
2022 - 10.3390/ijms232314636
International journal of molecular sciences, Vol. 23 (november 2022)
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5.
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9 p, 771.4 KB |
Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans
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Di Giorgi, Alessandro (Università Politecnica delle Marche) ;
Sprega, Giorgia (Università Politecnica delle Marche) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Di Trana, Annagiulia (Istituto Superiore di Sanità) ;
Varì, Maria Rosaria (Instituto Superiore di Sanità) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Zaami, Simona (Università La Sapienza) ;
Lo Faro, Alfredo Fabrizio (Università Politecnica delle Marche) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. [...]
2023 - 10.3390/ijms24087395
International journal of molecular sciences, Vol. 24 (april 2023)
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12 p, 1.5 MB |
Usefulness of Oral Fluid for Measurement of Methylone and Its Metabolites : Correlation with Plasma Drug Concentrations and the Effect of Oral Fluid pH
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Sprega, Giorgia (Università Politecnica delle Marche) ;
Di Giorgi, Alessandro (Università Politecnica delle Marche) ;
Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Tini, Anastasio (Università Politecnica delle Marche) ;
Pichini, Simona (Istituto Superiore di Sanità) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche) ;
Lo Faro, Alfredo Fabrizio (Università Politecnica delle Marche) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The aim of this study was to investigate methylone and its metabolites concentration in oral fluid following controlled increasing doses, focusing on the effect of oral fluid pH. Samples were obtained from a clinical trial where twelve healthy volunteers participated after ingestion of 50, 100, 150 and 200 mg of methylone. [...]
2023 - 10.3390/metabo13040468
Metabolites, Vol. 13 (march 2023)
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7.
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21 p, 354.4 KB |
Antidepressant Drugs and COVID-19 : A Review of Basic and Clinical Evidence
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Mas, Marta (Universitat Pompeu Fabra) ;
García-Vicente, Juan Antonio (Institut Català de la Salut) ;
Estrada-Gelonch, Anaïs (TFS Healthcare) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torrens, Marta (Hospital del Mar (Barcelona, Catalunya)) ;
Farre, Magi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Universitat Autònoma de Barcelona
The COVID-19 pandemic has encouraged the repurposing of existing drugs as a shorter development strategy in order to support clinicians with this difficult therapeutic dilemma. There is evidence to support the theory that some antidepressants can reduce concentrations of different cytokines in humans and animals and, recently, the antiviral activity of some antidepressants against SARS-CoV-2 has been reported. [...]
2022 - 10.3390/jcm11144038
Journal of clinical medicine, Vol. 11 (july 2022)
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8.
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13 p, 1.4 MB |
Pharmacological effects of methylone and MDMA in humans
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Poyatos, Lourdes (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Hladun, Olga (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Núñez-Montero, Melani (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
de la Rosa, Georgina (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Martín, Soraya (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Barriocanal, Ana María (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Carabias, Lydia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Kelmendi, Benjamin (Yale University School of Medicine. Department of Psychiatry) ;
Taoussi, Omayema (Università Politecnica delle Marche. Department of Excellence-Biomedical Sciences and Public Health) ;
Busardo, Francesco Paolo (Università Politecnica delle Marche. Department of Excellence-Biomedical Sciences and Public Health) ;
Fonseca, Francina 1972- (Institut de Neuropsiquiatria i Adiccions (Barcelona)) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Pichini, Simona (Istituto Superiore di Sanità. National Centre on Addiction and Doping (Itàlia)) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Methylone is one of the most common synthetic cathinones popularized as a substitute for 3,4-methylenedioxymethamphetamine (MDMA, midomafetamine) owing to its similar effects among users. Both psychostimulants exhibit similar chemistry (i. [...]
2023 - 10.3389/fphar.2023.1122861
Frontiers in Pharmacology, Vol. 14 (february 2023)
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10 p, 635.2 KB |
BDNF and Cortisol in the Diagnosis of Cocaine-Induced Depression
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Fonseca, Francina 1972- (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Mestre-Pinto, Joan Ignasi (Universitat Pompeu Fabra. Departament de Medicina i Ciències de la Vida) ;
Rodríguez-Minguela, Rocío (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Papaseit, Esther (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Pérez-Mañá, Clara (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Langohr, Klaus (Institut Hospital del Mar d'Investigacions Mèdiques) ;
Barbuti, Margherita (University Hospital of Pisa (Pisa, Itàlia)) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal)
Major depressive disorder (MDD) and cocaine use disorder (CUD) are related with disability and high mortality rates. The assessment and treatment of psychiatric comorbidity is challenging due to its high prevalence and its clinical severity, mostly due to suicide rates and the presence of medical comorbidities. [...]
2022 - 10.3389/fpsyt.2022.836771
Frontiers in psychiatry, Vol. 13 (march 2022)
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10.
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19 p, 765.0 KB |
Abuse Potential of Cathinones in Humans : a Systematic Review
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Poyatos, Lourdes (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Torres, Adrian (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Papaseit, Esther (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Pérez-Mañá, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Hladun, Olga (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Núñez-Montero, Melani (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
de la Rosa, Georgina (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia) ;
Torrens, Marta (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ;
Fuster, Daniel (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Muga, Roberto (Universitat Autònoma de Barcelona. Departament de Medicina) ;
Farre, Magi (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Introduction and objective: Assessing the abuse potential of new substances with central nervous system activity is essential for preventing possible risks of misuse and addiction. The same methodology is recommended for the evaluation of the abuse potential of recreational drugs. [...]
2022 - 10.3390/jcm11041004
Journal of clinical medicine, Vol. 11 Núm. 4 (february 2022) , p. 1004
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