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| Pàgina inicial > Articles > Articles publicats > Abuse Potential of Cathinones in Humans : |
(Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) (Universitat Autònoma de Barcelona. Departament de Medicina) (Universitat Autònoma de Barcelona. Departament de Medicina) (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
| Data: | 2022 |
| Resum: | Introduction and objective: Assessing the abuse potential of new substances with central nervous system activity is essential for preventing possible risks of misuse and addiction. The same methodology is recommended for the evaluation of the abuse potential of recreational drugs. This systematic review aims to assess the pharmacological effects related to the abuse potential and pharmacokinetics of cathinones, which are evaluated in both experimental and prospective observational studies in humans. Materials and Methods: A systematic search of the published literature was conducted to retrieve studies that had administered cathinone, mephedrone, methylone, and diethylpropion to evaluate their acute pharmacological effects related to abuse potential. Results: The search yielded 583 results, 18 of which were included to assess the abuse potential of cathinone (n = 5), mephedrone (n = 7), methylone (n = 1), and diethylpropion (n = 5). All four substances induce stimulant and euphorigenic effects that resemble those of amphetamines and MDMA, and their different intensities may be associated with varying levels of abuse potential. Conclusions: Cathinone, mephedrone, methylone, and diethylpropion induce a range of desirable and reinforcing effects that may, to some extent, result in abuse potential. Further investigation is needed to minimize and prevent their impact on society and public health. |
| Ajuts: | Instituto de Salud Carlos III PI14/00715 Instituto de Salud Carlos III PI17/01962 Instituto de Salud Carlos III PI20/00879 Instituto de Salud Carlos III FI18/00179 Instituto de Salud Carlos III RD21/0009/0001 Instituto de Salud Carlos III RD21/0009/0004 Ministerio de Sanidad, Servicios Sociales e Igualdad 2018I020 |
| Nota: | This research was partially funded by the Instituto de Salud Carlos III (ISCIII, Fondo Investigaci?n Sanitaria (FIS)-Fondo Europeo de Desarrollo Regional (FEDER)), grant number FIS PI17/01962, FIS PI14/00715 and FIS PI20/00879, and predoctoral PFIS FI18/00179 (L. Poyatos), ISCIII-Redes de Investigaci?n Cooperativa Orientadas a Resultados en Salud (RICORS)-Red de Investigaci?n en Atenci?n Primaria de Adicciones (RIAPAd), grant numbers RD21/0009/0001 and RD21/0009/0004, and Ministerio de Sanidad, Pol?tica Social e Igualdad (Plan Nacional sobre Drogas-PNSD), grant number 2018I020. |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article de revisió ; recerca ; Versió publicada |
| Matèria: | Cathinone ; Mephedrone (4-methylmethcathinone) ; Methylone (3,4-methylenedioxymethcathinone) ; Diethylpropion ; Abuse potential ; New psychoactive substance ; Pharmacological effects ; Pharmacokinetics |
| Publicat a: | Journal of clinical medicine, Vol. 11 Núm. 4 (february 2022) , p. 1004, ISSN 2077-0383 |
