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Resultats globals: 5 registres trobats en 0.01 segons.
Articles, 5 registres trobats
Articles 5 registres trobats  
1.
36 p, 4.7 MB METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer / García-Vílchez, Raquel (Instituto de Investigación Biomédica de Salamanca) ; Añazco-Guenkova, Ana M. (Instituto de Investigación Biomédica de Salamanca) ; Dietmann, Sabine (Washington University School of Medicine in St. Lou) ; López, Judith (Instituto de Investigación Biomédica de Salamanca) ; Morón-Calvente, Virginia (Instituto de Investigación Biomédica de Salamanca) ; D'Ambrosi, Silvia (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Nombela, Paz (Instituto de Investigación Biomédica de Salamanca) ; Zamacola, Kepa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Mendizabal, Isabel (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; García-Longarte, Saioa (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Zabala-Letona, Amaia (Centro de Investigación Biomédica en Red de Cáncer) ; Astobiza, Ianire (Centro de Investigación Biomédica en Red de Cáncer) ; Fernández, Sonia (Centro de Investigación Biomédica en Red de Cáncer) ; Paniagua, Alejandro (Universidad de Salamanca) ; Miguel-López, Borja (Instituto de Investigación Biomédica de Salamanca) ; Marchand, Virginie (Université de Lorraine, France) ; Alonso-López, Diego (Universidad de Salamanca) ; Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; García-Tuñón, Ignacio (Universidad de Salamanca) ; Ugalde-Olano, Aitziber (Hospital de Basurto (Bilbao, Biscaia)) ; Loizaga-Iriarte, Ana (Hospital de Basurto (Bilbao, Biscaia)) ; Lacasa-Viscasillas, Isabel (Hospital de Basurto (Bilbao, Biscaia)) ; Unda, Miguel (Hospital de Basurto (Bilbao, Biscaia)) ; Azkargorta, Mikel (Carlos III Networked Proteomics Platform (ProteoRed-ISCIII), Madrid) ; Elortza, Félix (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Bárcena, Laura (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Gonzalez-Lopez, Monika (CIC bioGUNE, Basque Research and Technology Alliance (BRTA)) ; Aransay, Ana M. (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas) ; Di Domenico, Tomás (Bioinformatics Unit, Spanish National Cancer Research Centre (CNIO)) ; Sánchez-Martín, Manuel A. (Universidad de Salamanca) ; De Las Rivas, Javier (Universidad de Salamanca) ; Guil, S. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Motorin, Yuri (Université de Lorrain) ; Helm, Mark (Johannes Gutenberg-University Mainz, Germany) ; Pandolfi, Pier Paolo (University of Turin, Italy) ; Carracedo, Arkaitz (Centro de Investigación Biomédica en Red de Cáncer) ; Blanco, Sandra (Universidad de Salamanca)
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. [...]
2023 - 10.1186/s12943-023-01809-8
Molecular cancer, Vol. 22 Núm. 1 (july 2023)  
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2.
19 p, 2.4 MB Global Impairment of Immediate-Early Genes Expression in Rett Syndrome Models and Patients Linked to Myelination Defects / Petazzi, Paolo (Instituto de Salud Carlos III) ; Jorge-Torres, Olga Caridad (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Gomez, Antonio (Universitat de Vic - Universitat Central de Catalunya) ; Scognamiglio, Iolanda (Institut d'Investigació Biomèdica de Bellvitge) ; Serra-Musach, Jordi (Institut d'Investigació Biomèdica de Bellvitge) ; Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Grases, Daniela (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Xiol, Clara (Hospital Sant Joan de Déu (Manresa)) ; O'Callaghan, Maria del Mar (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Armstrong, Judith (Centro de Investigación Biomédica en Red de Enfermedades Raras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Guil, Sonia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Rett syndrome (RTT) is a severe neurodevelopmental disease caused almost exclusively by mutations to the MeCP2 gene. This disease may be regarded as a synaptopathy, with impairments affecting synaptic plasticity, inhibitory and excitatory transmission and network excitability. [...]
2023 - 10.3390/ijms24021453
International journal of molecular sciences, Vol. 24 Núm. 2 (january 2023)  
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3.
12 p, 12.0 MB Novel Targeting of DNA Methyltransferase Activity Inhibits Ewing Sarcoma Cell Proliferation and Enhances Tumor Cell Sensitivity to DNA Damaging Drugs by Activating the DNA Damage Response / Cristalli, Camilla (IRCCS Istituto Ortopedico Rizzoli) ; Manara, Maria Cristina (IRCCS Istituto Ortopedico Rizzoli) ; Valente, Sergio (Sapienza University of Rome) ; Pellegrini, Evelin (IRCCS Istituto Ortopedico Rizzoli) ; Bavelloni, Alberto (IRCCS Istituto Ortopedico Rizzoli) ; De Feo, Alessandra (IRCCS Istituto Ortopedico Rizzoli) ; Blalock, William (Istituto di Genetica Molecolare-Luigi Luca Cavalli Sforza) ; Di Bello, Elisabetta (Sapienza University of Rome) ; Piñeyro, David (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Tirado, Oscar M. (Institut d'Investigació Biomèdica de Bellvitge) ; Mai, Antonello (Sapienza University of Rome) ; Scotlandi, Katia (IRCCS Istituto Ortopedico Rizzoli)
DNA methylation is an important component of the epigenetic machinery that regulates the malignancy of Ewing sarcoma (EWS), the second most common primary bone tumor in children and adolescents. Coordination of DNA methylation and DNA replication is critical for maintaining epigenetic programming and the DNMT1 enzyme has been demonstrated to have an important role in both maintaining the epigenome and controlling cell cycle. [...]
2022 - 10.3389/fendo.2022.876602
Frontiers in Endocrinology, Vol. 13 (31 2022) , p. 876602  
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4.
14 p, 574.9 KB Experimental and Bioinformatic Approaches to Studying DNA Methylation in Cancer / Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Universitat Autònoma de Barcelona
DNA methylation is an essential epigenetic mark. Alterations of normal DNA methylation are a defining feature of cancer. Here, we review experimental and bioinformatic approaches to showcase the breadth and depth of information that this epigenetic mark provides for cancer research. [...]
2022 - 10.3390/cancers14020349
Cancers, Vol. 14 Núm. 2 (1-2 2022) , p. 349  
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5.
9 p, 1.1 MB Refinement of computational identification of somatic copy number alterations using DNA methylation microarrays illustrated in cancers of unknown primary / Blecua, Pedro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; De Villasante, Izar (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Merkel, Angelika (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Musulén, Eva (Hospital Universitari General de Catalunya) ; Coll-Sanmartin, Laia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
High-throughput genomic technologies are increasingly used in personalized cancer medicine. However, computational tools to maximize the use of scarce tissues combining distinct molecular layers are needed. [...]
2022 - 10.1093/bib/bbac161
Briefings in Bioinformatics, Vol. 23 Núm. 5 (september 2022) , p. bbac161  
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