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1.
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16 p, 2.8 MB |
SIRT1 regulates DNA damage signaling through the PP4 phosphatase complex
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Rasti, George (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Becker, Maximilian (Institut d'Investigació Biomèdica de Bellvitge) ;
Vazquez, Berta N. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Espinosa-Alcantud, Maria (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Duran, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gámez-García, Andrés (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ianni, Alessandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Gonzalez, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bosch-Presegué, Laia (Institut d'Investigació Biomèdica de Bellvitge) ;
Marazuela Duque, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guitart-Solanes, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Segura-Bayona, Sandra (Institute for Research in Biomedicine (IRB Barcelona)) ;
Bech-Serra, Joan Josep (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Scher, Michael (University of Medicine and Dentistry of New Jersey, USA) ;
Serrano, Lourdes (The City University of New York, USA) ;
Shankavaram, Uma (National Cancer Institute, Bethesda, USA) ;
Erdjument-Bromage, Hediye (University School of Medicine, New York) ;
Tempst, Paul (Memorial Sloan-Kettering Cancer Center, New York) ;
Reinberg, Danny (New York University School of Medicine) ;
Olivella, Mireia (Universitat de Vic. Universitat Central de Catalunya) ;
Stracker, Travis H. (Institute for Research in Biomedicine (IRB Barcelona)) ;
De La Torre, Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
The Sirtuin family of NAD+-dependent enzymes plays an important role in maintaining genome stability upon stress. Several mammalian Sirtuins have been linked directly or indirectly to the regulation of DNA damage during replication through Homologous recombination (HR). [...]
2023 -  10.1093/nar/gkad504
Nucleic acids research, Vol. 51 Núm. 13 (july 2023) , p. 6754-6769
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2.
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11 p, 1.9 MB |
A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin
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González Miranda, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bosch-Presegué, Laia (Institut de Recerca I Innovació en Ciències de La Vida i de La Salut a La Catalunya Central) ;
Marazuela Duque, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Guitart-Solanes, Anna (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Espinosa-Alcantud, María Dolores (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernandez, Agustín F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Brown, Jeremy P. (Department of Immunology and Inflammation. The Hammersmith Hospital) ;
Ausió, Juan (University of Victoria. Department of Biochemistry and Microbiology) ;
Vazquez Prat, Berta Nieves (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ;
Singh, Prim B. (Nazarbayev University School of Medicine) ;
Fraga, Mario F. (Centro de Investigación Biomédica en Red de Enfermedades Raras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Pericentric heterochromatin (PCH) plays an essential role in the maintenance of genome integrity and alterations in PCH have been linked to cancer and aging. HP1 α, β, and γ, are hallmarks of constitutive heterochromatin that are thought to promote PCH structure through binding to heterochromatin-specific histone modifications and interaction with a wide range of factors. [...]
2023 - 10.3389/fcell.2023.1293122
Frontiers in Cell and Developmental Biology, Vol. 11 (2023) , p. 1293122
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3.
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9 p, 1.5 MB |
Validation of a DNA methylation microarray for 285,000 CpG sites in the mouse genome
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García-Prieto, Carlos A (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Álvarez-Errico, Damiana (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Musulén, Eva (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Bueno-Costa, Alberto (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Mouse has been extensively used as a model organism in many studies to characterize biological pathways and drug effects and to mimic human diseases. Similar DNA sequences between both species facilitate these types of experiments. [...]
2022 - 10.1080/15592294.2022.2053816
Epigenetics, Vol. 17 Núm. 12 (december 2022) , p. 1677-1685
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4.
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14 p, 2.9 MB |
SIRT1 activation with neuroheal is neuroprotective but SIRT2 inhibition with AK7 is detrimental for disconnected motoneurons
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Romeo-Guitart, David (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Leiva-Rodríguez, Tatiana (Universitat Autònoma de Barcelona. Institut de Neurociències) ;
Espinosa-Alcantud, María Dolores (Institut d'Investigació Biomèdica de Bellvitge) ;
Sima, Núria (Institut d'Investigació Biomèdica de Bellvitge) ;
Vaquero, Alejandro (Institut d'Investigació Biomèdica de Bellvitge) ;
Domínguez- Martín, Helena (Universidad de Sevilla) ;
Ruano, Diego (Universidad de Sevilla) ;
Casas Louzao, Caty (Universitat Autònoma de Barcelona. Institut de Neurociències)
Sirtuin 1 (SIRT1) activity is neuroprotective, and we have recently demonstrated its role in the retrograde degenerative process in motoneurons (MNs) in the spinal cord of rats after peripheral nerve root avulsion (RA) injury. [...]
2018 - 10.1038/s41419-018-0553-6
Cell death and disease, Vol. 9 (may 2018)
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5.
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26 p, 2.8 MB |
Shikimic acid protects skin cells from UV-induced senescence through activation of the NAD+-dependent deacetylase SIRT1
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Martínez-Gutiérrez, Alfredo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Fernández-Duran, Irene (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Marazuela Duque, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
Simonet, Nicolas G.. (Institut d'Investigació Biomèdica de Bellvitge) ;
Yousef, Ibraheem (ALBA Laboratori de Llum de Sincrotró) ;
Martínez-Rovira, Immaculada (Universitat Autònoma de Barcelona. Departament de Física) ;
Martínez-Hoyos, Josefina (Mesostetic Pharma Group) ;
Vaquero, Alejandro (Institut d'Investigació Biomèdica de Bellvitge)
UV radiation is one of the main contributors to skin photoaging by promoting the accumulation of cellular senescence, which in turn induces a proinflammatory and tissue-degrading state that favors skin aging. [...]
2021 - 10.18632/aging.203010
Aging (Albany NY), Vol. 13, Issue 9 (April 2021) , p. 12308-12333
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6.
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16 p, 2.3 MB |
SIRT7 mediates L1 elements transcriptional repression and their association with the nuclear lamina
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Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Thackray, J. K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Simonet, N. G. (Institut d'Investigació Biomèdica de Bellvitge) ;
Chahar, S. (Montpellier Institute of Molecular Genetics (IGMM). CNRS. University of Montpellier) ;
Kane-Goldsmith, N. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Newkirk, S. J. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Lee, S. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Xing, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Verzi, M. P. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
An, W. (Department of Pharmaceutical Sciences. College of Pharmacy and Allied Health Professions. South Dakota State University) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tischfield, J. A. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Serrano, L. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Universitat Autònoma de Barcelona
Long interspersed elements-1 (LINE-1, L1) are retrotransposons that hold the capacity of self-propagation in the genome with potential mutagenic outcomes. How somatic cells restrict L1 activity and how this process becomes dysfunctional during aging and in cancer cells is poorly understood. [...]
2019 - 10.1093/nar/gkz519
Nucleic acids research, Vol. 47 Núm. 15 (january 2019) , p. 7870-7885
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7.
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22 p, 5.2 MB |
Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment
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Urdinguio, Rocío G. (Instituto de Oncología de Asturias-IUOPA) ;
López, Virginia (Centro de Investigación en Nanociencia y Nanotecnología (Oviedo, Astúries)) ;
Fernández Bayón, Gustavo (Instituto de Oncología de Asturias-IUOPA) ;
Díaz de la Guardia, Rafael (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sierra, Marta I. (Instituto de Oncología de Asturias-IUOPA) ;
García-Toraño, Estela (Instituto de Oncología de Asturias-IUOPA) ;
Pérez, Raúl F. (Instituto de Oncología de Asturias-IUOPA) ;
García, María G. (Instituto de Oncología de Asturias-IUOPA) ;
Carella, Antonella (Instituto de Oncología de Asturias-IUOPA) ;
Pruneda, Patricia C. (Instituto de Oncología de Asturias-IUOPA) ;
Prieto, Cristina (Instituto de Oncología de Asturias-IUOPA) ;
Dmitrijeva, Marija (Instituto de Oncología de Asturias-IUOPA) ;
Santamarina-Ojeda, Pablo (Instituto de Oncología de Asturias-IUOPA) ;
Belmonte, Thalia (Instituto de Oncología de Asturias-IUOPA) ;
Mangas, Cristina (Instituto de Oncología de Asturias-IUOPA) ;
Diaconu, Elena (Instituto de Oncología de Asturias-IUOPA) ;
Ferrero, Cecilia (Instituto de Oncología de Asturias-IUOPA) ;
Tejedor, Juan Ramón (Instituto de Oncología de Asturias-IUOPA) ;
Fernandez-Morera, Juan Luis (Instituto de Oncología de Asturias-IUOPA) ;
Bravo, Cristina (Instituto de Oncología de Asturias-IUOPA) ;
Bueno, Clara (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sanjuan-Pla, Alejandra (Instituto de Investigación Sanitaria La Fe) ;
Rodríguez López, Ramón María (Hospital Universitario Central de Asturias) ;
Suárez-Álvarez, Beatriz (Hospital Universitario Central de Asturias) ;
López-Larrea, Carlos (Hospital Universitario Central de Asturias) ;
Bernal, Teresa (Hospital Universitario Central de Asturias) ;
Colado, Enrique (Hospital Universitario Central de Asturias) ;
Balbín, Milagros (Hospital Universitario Central de Asturias) ;
García-Suarez, Olivia (Universidad de Oviedo. Departamento de Morfología y Biología Celular) ;
Chiara, María Dolores (Hospital Universitario Central de Asturias) ;
Sáenz De Santa María, Inés (Hospital Universitario Central de Asturias) ;
Rodríguez, Francisco (Universidad de Oviedo. Departamento de Bioquímica y Biología Molecular) ;
Pando-Sandoval, Ana (Hospital Universitario Central de Asturias) ;
Rodrigo-Sáez, Luis (Hospital Universitario Central de Asturias) ;
Santos, Laura. (Instituto de Investigación Sanitaria del Principado de Asturias) ;
Salas, Ana (Universidad de Oviedo. Servicio de Citometría) ;
Vallejo-Díaz, Jesús (Centro Nacional de Biotecnología (CNB-CSIC)) ;
Carrera, Ana C. (Centro Nacional de Biotecnología (CNB-CSIC)) ;
Rico, Daniel (Newcastle University. Institute of Cellular Medicine) ;
Hernández-López, Inmaculada (Newcastle University. Institute of Cellular Medicine) ;
Vayá, Amparo (Hospital Universitari i Politècnic La Fe (València)) ;
Ricart, José María (Quirón Clinic. Dermatology Service) ;
Seto, Edward (George Washington University Cancer Center) ;
Sima, Núria (Institut d'Investigació Biomèdica de Bellvitge) ;
Vaquero, Alejandro (Institut d'Investigació Biomèdica de Bellvitge) ;
Valledor, Luís (Universidad de Oviedo. Facultad de Biología) ;
Cañal Villanueva, María Jesús Fátima (Universidad de Oviedo. Facultad de Biología) ;
Pisano, David (Centro Nacional de Investigaciones Oncológicas) ;
Graña-Castro, Osvaldo (Centro Nacional de Investigaciones Oncológicas) ;
Thomas, Tim (University of Melbourne. Department of Medical Biology (Austràlia)) ;
Voss, Anne Kathrin (University of Melbourne. Department of Medical Biology (Austràlia)) ;
Menéndez Bujan, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Villar-Garea, Ana (University of Regensburg) ;
Deutzmann, Rainer (University of Regensburg) ;
Fernández, Agustín F (Instituto de Oncología de Asturias-IUOPA) ;
Fraga, Mario F. (Centro de Investigación en Nanociencia y Nanotecnología (Oviedo, Astúries)) ;
Universitat Autònoma de Barcelona
Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. [...]
2019 - 10.1093/nar/gkz195
Nucleic acids research, Vol. 47 Núm. 10 (april 2019) , p. 5016-5037
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8.
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17 p, 1.6 MB |
SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1
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Simonet, Nicolas G.. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Thackray, J. K. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
Vazquez Prat, Berta Nieves (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ianni, A. (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodelling) ;
Espinosa-Alcantud, María Dolores (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morales-Sanfrutos, J. (Universitat Pompeu Fabra) ;
Hurtado-Bagès, Sarah. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Sabidó, Eduard (Universitat Pompeu Fabra) ;
Buschbeck, Marcus (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Tischfield, J. (Department of Genetics. Human Genetics Institute of New Jersey. Rutgers University) ;
De La Torre Gómez, Gisela Carolina (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Esteller, M. (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Braun, T. (Max Planck Institute for Heart and Lung Research. Department of Cardiac Development and Remodelling) ;
Olivella, Mireia (Universitat de Vic. Facultat de Ciències i Tecnologia) ;
Serrano, L. (Department of Science. BMCC. City University of New York (CUNY)) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono-adenosine 5'-diphosphate (ADP)-ribosyltransferase (mADPRT) activity. [...]
2020 - 10.1126/sciadv.aaz2590
Science advances, Vol. 6 Núm. 30 (july 2020) , p. aaz2590
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9.
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15 p, 1.5 MB |
Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases
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Wössner, Nathalie (Institute of Pharmaceutical Sciences. University of Freiburg. Department of Pharmaceutical and Medicinal Chemistry) ;
Alhalabi, Zayan (Institute of Pharmacy. University of Halle-Wittenberg. Department of Medicinal Chemistry) ;
González Miranda, Jessica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Swyter, Sören (Institute of Pharmaceutical Sciences. University of Freiburg) ;
Gan, Jin (Oncode Institute, Leiden University Medical Center, Leiden) ;
Schmidtkunz, Karin (Department of Pharmaceutical and Medicinal Chemistry. Institute of Pharmaceutical Sciences. University of Freiburg) ;
Zhang, Lin (Department of Protein Crystallography. Institute of Biochemistry. University of Freiburg) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ovaa, Huib (Oncode Institute. Leiden University Medical Center) ;
Einsle, Oliver (Department of Protein Crystallography. Institute of Biochemistry. University of Freiburg) ;
Sippl, Wolfgang (Department of Medicinal Chemistry. Institute of Pharmacy. University of Halle-Wittenberg) ;
Jung, Manfred (Department of Pharmaceutical and Medicinal Chemistry. Institute of Pharmaceutical Sciences. University of Freiburg) ;
Universitat Autònoma de Barcelona
Sirtuin 1 (Sirt1) is a NAD dependent lysine deacetylase associated with the pathogenesis of various diseases including cancer. In many cancer types Sirt1 expression is increased and higher levels have been associated with metastasis and poor prognosis. [...]
2020 - 10.3389/fonc.2020.00657
Frontiers in Oncology, Vol. 10 (30 2020) , p. 657
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10.
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17 p, 3.2 MB |
SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages
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Li, Tianlu (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Garcia-Gomez, Antonio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Morante-Palacios, Octavio (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ciudad, Laura (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Özkaramehmet, S. (Institut d'Investigació Biomèdica de Bellvitge) ;
Van Dijck, E. (Institut d'Investigació Biomèdica de Bellvitge) ;
Rodríguez-Ubreva, Javier (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vaquero, Alejandro (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Ballestar, Esteban (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Universitat Autònoma de Barcelona
Sirtuins 1 and 2 (SIRT1/2) are two NAD-dependent deacetylases with major roles in inflammation. In addition to deacetylating histones and other proteins, SIRT1/2-mediated regulation is coupled with other epigenetic enzymes. [...]
2020 - 10.1093/nar/gkz1127
Nucleic acids research, Vol. 48 Núm. 2 (24 2020) , p. 665-681
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