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2 p, 442.7 KB |
Proposen combatre les infeccions bacterianes a través de la manipulació del sistema de "quorum sensing"
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Un estudi realitzat pel Grup de Patogènesi Bacteriana i Antimicrobians de l'IBB i del Departament de Genètica i de Microbiologia de la UAB ha assolit avenços significatius en la recerca d'estratègies per combatre infeccions causades per bacteris patògens. [...]
Un estudio realizado por el Grupo de Patogénesis Bacteriana y Antimicrobianos del IBB y del Departamento de Genética y Microbiología de la UAB ha alcanzado avances significativos en la búsqueda de estrategias para combatir infecciones causadas por bacterias patógenas. [...]
A study conducted by researchers from the Bacterial Pathogenesis and Antimicrobials Group at the IBB and the Department of Genetics and Microbiology at the UAB has made significant advances in the search for strategies to fight infections caused by pathogenic bacteria. [...]
2024
UAB divulga, Març 2024
3 documents
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16 p, 1.0 MB |
Synthesis and evaluation of aromatic BDSF bioisosteres on biofilm formation and colistin sensitivity in pathogenic bacteria
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Horgan, Conor (University College Cork) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
O'Driscoll, Michelle (University College Cork) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
O'Sullivan, Timothy (University College Cork)
The diffusible signal factor family (DSF) of molecules play an important role in regulating intercellular communication, or quorum sensing, in several disease-causing bacteria. These messenger molecules, which are comprised of cis-unsaturated fatty acids, are involved in the regulation of biofilm formation, antibiotic tolerance, virulence and the control of bacterial resistance. [...]
2023 -  10.1016/j.ejmech.2023.115819
European Journal of Medicinal Chemistry, Vol. 261 (December 2023) , art. 115819
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17 p, 1.6 MB |
A TetR-Like Transcriptional Regulator Involved in Fatty Acid Metabolism Is Controlled by Quorum Sensing Signals
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Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Bravo, Marc (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Esteve-Codina, Anna (Centre de Regulació Genòmica) ;
Dabad, Marc (Centre de Regulació Genòmica) ;
Gut, Marta (Centre de Regulació Genòmica) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Stenotrophomonas maltophilia is an environmental bacterium as well as an emerging opportunistic multidrug-resistant pathogen. They use the endogenous diffusible signal factor (DSF) quorum sensing (QS) system to coordinate population behavior and regulate virulence processes but can also respond to exogenous N-acyl-homoserine lactone (AHL) signals produced by neighboring bacteria. [...]
2023 - 10.1128/aem.00635-23
Applied and Environmental Microbiology, Vol. 89, Issue 6 (June 2023)
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20 p, 3.6 MB |
Improved mini-Tn 7 Delivery Plasmids for Fluorescent Labeling of
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Mamat, Uwe (Research Center Borstel) ;
Hein, Manuel (Research Center Borstel) ;
Grella, Dörte (Research Center Borstel) ;
Taylor, Claire S. (Research Center Borstel) ;
Scholzen, Thomas (Research Center Borstel) ;
Alio, Ifey (Universität Hamburg. Department of Microbiology and Biotechnology) ;
Streit, Wolfgang R. (Universität Hamburg. Department of Microbiology and Biotechnology) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Coves, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Schaible, Ulrich E. (Research Center Borstel)
Fluorescently labeled bacterial cells have become indispensable for many aspects of microbiological research, including studies on biofilm formation as an important virulence factor of various opportunistic bacteria of environmental origin such as . [...]
2023 - 10.1128/aem.00317-23
Applied and Environmental Microbiology, Vol. 89, Issue 6 (June 2023)
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16 p, 7.0 MB |
Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens
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Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lyons, Thérèse (University College Cork. School of Pharmacy) ;
Mamat, Uwe (Leibniz Lung Center. Cellular Microbiology) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Elshafee, Osama (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ;
Brunke, Sascha (Leibniz Institute for Natural Product Research and Infection Biology. Department of Microbial Pathogenicity Mechanisms) ;
Gahan, Cormac G.M. (University College Cork. APC Microbiome Ireland) ;
O'Driscoll, Michelle (University College Cork. Analytical and Biological Chemistry Research Facility) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
O'Sullivan, Timothy P. (University College Cork. Analytical and Biological Chemistry Research Facility)
Diseases caused by biofilm-forming pathogens are becoming increasingly prevalent and represent a major threat to human health. This trend has prompted a search for novel inhibitors of microbial biofilms which could, for example, be used to potentiate existing antibiotics. [...]
2022 - 10.1016/j.ejmech.2022.114678
European Journal of Medicinal Chemistry, Vol. 242 (November 2022) , art. 114678
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2 p, 722.3 KB |
Noves molècules que inhibeixen la formació de biofilm en diversos patògens oportunistes
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Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Investigadors del grup de recerca en Patogènesi Bacteriana i Antimicrobians de l'Institut de Biotecnologia i de Biomedicina i del Departament de Genètica i de Microbiologia (IBB) i del Departament de Genètica i de Microbiologia han avaluat diversos compostos que han demostrat inhibir la formació de biofilm en patògens humans oportunistes d'importància clínica. [...]
Investigadores del grupo de investigación en Patogénesis Bacteriana y Antimicrobianos del Instituto de Biotecnología y de Biomedicina (IBB) y del Departamento de Genética y Microbiología de la UAB han evaluado varios compuestos que han demostrado inhibir la formación de biofilm en patógenos humanos oportunistas de importancia clínica. [...]
Researchers from the Bacterial Pathogenesis and Antimicrobials group of the Institut de Biotecnologia i de Biomedicina (IBB) and the Department of Genetics and Microbiology at UAB, have evaluated several compounds that have been shown to inhibit biofilm formation in important opportunistic human pathogens. [...]
2022
UAB divulga, Setembre 2022
3 documents
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15 p, 2.0 MB |
Strain-specific interspecies interactions between co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization
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Gomes Fernandes, Meissiner (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gómez Camacho, Andromeda Celeste (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bravo, Marc (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Prat i Aymerich, Cristina (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lacoma, Alicia (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Dual species interactions in co-isolated pairs of Staphylococcus aureus and Pseudomonas aeruginosa from patients with tracheobronchitis or bronchial colonization were examined. The genetic and phenotypic diversity between the isolates was high making the interactions detected strain-specific. [...]
2022 - 10.1038/s41598-022-07018-5
Scientific reports, Vol. 12 (March 2022) , art. 3374
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15 p, 1.6 MB |
Genetic Variants of the DSF Quorum Sensing System in Stenotrophomonas maltophilia Influence Virulence and Resistance Phenotypes Among Genotypically Diverse Clinical Isolates
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Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Huedo Moreno, Pol (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Martínez-Servat, Sònia (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mamat, Uwe (Leibniz Lung Center) ;
Coves, Xavier (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Llanas, Ferran (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Roca, Ignasi (Institut de Salut Global de Barcelona) ;
Vila Estapé, Jordi (Institut de Salut Global de Barcelona) ;
Schaible, Ulrich E. (Leibniz Lung Center) ;
Daura i Ribera, Xavier (Institució Catalana de Recerca i Estudis Avançats) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
The pathogenicity of Stenotrophomonas maltophilia is regulated in part by its quorum sensing (QS) system. The main QS signaling molecule in S. maltophilia is known as diffusible signal factor (DSF), and the rpf gene cluster is responsible for its synthesis and perception. [...]
2020 - 10.3389/fmicb.2020.01160
Frontiers in microbiology, Vol. 11 (June 2020) , art. 1160
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12 p, 2.3 MB |
The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia
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Gröschel, Matthias I. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis) ;
Meehan, Conor J. (University of Bradford. School of Chemistry and Bioscience) ;
Barilar, Ivan (Research Center Borstel. Molecular and Experimental Mycobacteriology) ;
Diricks, Margo (BioMérieux) ;
Gonzaga, Aitor (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures) ;
Steglich, Matthias (Leibniz Institute DSMZ. German Collection of Microorganisms and Cell Cultures) ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Scherer, Isabell-Christin (Universitätsklinikum Schleswig-Holstein (Alemanya)) ;
Mamat, Uwe (Cellular Microbiology, Research Center Borstel) ;
Luz, Christian F. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention) ;
De Bruyne, Katrien (bioMérieux, Applied Maths NV) ;
Utpatel, Christian (Research Center Borstel. Molecular and Experimental Mycobacteriology) ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Kampmeier, Stefanie (University Hospital of Münster (Alemanya)) ;
Rahman, Nurdyana Abdul (Singapore General Hospital. Department of Microbiology) ;
Kresken, Michael (Rheinische Fachhochschule Köln gGmbH) ;
van der Werf, Tjip S. (University Medical Center Groningen. Department of Pulmonary Diseases & Tuberculosis) ;
Alio, Ifey (University of Hamburg. Department of Microbiology and Biotechnology) ;
Streit, Wolfgang R. (University of Hamburg. Department of Microbiology and Biotechnology) ;
Zhou, Kai (Jinan University. Second Clinical Medical College) ;
Schwartz, Thomas (Karlsruhe Institute of Technology) ;
Rossen, John W. A. (University Medical Center Groningen. Department of Medical Microbiology and Infection Prevention) ;
Farhat, Maha R. (Massachusetts General Hospital (Boston)) ;
Schaible, Ulrich E. (Leibniz Research Alliance Infections'21) ;
Nübel, Ulrich (Technical University. Braunschweig Integrated Center of Systems Biology) ;
Rupp, Jan (German Center for Infection Research) ;
Steinmann, Joerg (Paracelsus Medical Private University) ;
Niemann, Stefan (Leibniz Research Alliance Infections'21) ;
Kohl, Thomas A. (German Center for Infection Research)
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. [...]
2020 - 10.1038/s41467-020-15123-0
Nature communications, Vol. 11 (April 2020) , art. 2044
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16 p, 3.0 MB |
The Pseudomonas aeruginosa substrate-binding protein Ttg2D functions as a general glycerophospholipid transporter across the periplasm
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Yero, Daniel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Díaz-Lobo, Mireia (Institut de Recerca Biomèdica) ;
Costenaro, Lionel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Conchillo-Solé, Oscar (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Mayo, Adrià (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Ferrer-Navarro, Mario (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Vilaseca, Marta (Institut de Recerca Biomèdica) ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Daura i Ribera, Xavier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
In Pseudomonas aeruginosa, Ttg2D is the soluble periplasmic phospholipid-binding component of an ABC transport system thought to be involved in maintaining the asymmetry of the outer membrane. Here we use the crystallographic structure of Ttg2D at 2. [...]
2021 - 10.1038/s42003-021-01968-8
Communications Biology, Vol. 4 (April 2021) , art. 448
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