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17 p, 8.3 MB |
Non-invasive electromechanical assessment during atrial fibrillation identifies underlying atrial myopathy alterations with early prognostic value
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Enríquez-Vázquez, Daniel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Quintanilla, Jorge G. (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
García-Escolano, Alba (Universidad Politécnica de Madrid) ;
Couselo-Seijas, Marinela (Centro Nacional de Investigaciones Cardiovasculares (CNIC)) ;
Simón-Chica, Ana (Centro Nacional de Investigaciones Cardiovasculares (CNIC)) ;
Lee, Peter (Essel Research and Development Inc.) ;
Alfonso-Almazán, José Manuel (Centro Nacional de Investigaciones Cardiovasculares (CNIC)) ;
Mahía, Patricia (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Redondo-Rodríguez, Andrés (Centro Nacional de Investigaciones Cardiovasculares (CNIC)) ;
Modrego, Javier (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ;
Ortega-Hernández, Adriana (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ;
Marcos-Alberca, Pedro (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Magni, Ricardo (Centro Nacional de Investigaciones Cardiovasculares (CNIC)) ;
Calvo, Enrique (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Gómez-Gordo, Rubén (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ;
Yan, Ping (University of Connecticut School of Medicine) ;
La Rosa, Giulio (Centro Nacional de Investigaciones Cardiovasculares (CNIC)) ;
Bustamante-Madrión, José (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ;
Pérez-García, Carlos Nicolás (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Martín-Sánchez, F. Javier (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ;
Calvo, David (Hospital Universitario Central de Asturiass) ;
de la Hera, Jesús M. (Hospital Universitario Central de Asturias) ;
García-Torrent, María Jesús (Universidad Complutense de Madrid) ;
García Osuna, Álvaro (Institut d'Investigació Biomèdica Sant Pau) ;
Ordoñez Llanos, Jorge 1952- (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Vázquez, Jesús (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares) ;
Pérez-Villacastín, Julián (Fundación Interhospitalaria para la Investigación Cardiovascular (FIC)) ;
Pérez-Castellano, Nicasio (Fundación Interhospitalaria para la Investigación Cardiovascular (FIC)) ;
Loew, Leslie M. (University of Connecticut School of Medicine) ;
Sánchez-González, Javier (Philips Healthcare Iberia, Madrid, Spain) ;
Gómez-Garre, Dulcenombre (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)) ;
Filgueiras-Rama, David (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Universitat Autònoma de Barcelona
Electromechanical characterization during atrial fibrillation (AF) remains a significant gap in the understanding of AF-related atrial myopathy. This study reports mechanistic insights into the electromechanical remodeling process associated with AF progression and further demonstrates its prognostic value in the clinic. [...]
2023 -  10.1038/s41467-023-40196-y
Nature communications, Vol. 14 (august 2023)
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2.
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14 p, 2.1 MB |
A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions
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Eraña, Hasier (ATLAS Molecular Pharma S. L) ;
Sampedro-Torres-Quevedo, Cristina (Basque Research and Technology Alliance) ;
Charco, Jorge M. (ATLAS Molecular Pharma S. L) ;
Díaz-Domínguez, Carlos M. (Instituto de Salut Carlos III. Centro de Investigación Biomédica en Red de Enfermedades infecciosas) ;
Peccati, Francesca (Basque Research and Technology Alliance) ;
San-Juan-Ansoleaga, Maitena (Basque Research and Technology Alliance) ;
Vidal Barba, Enric (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Gonçalves-Anjo, Nuno (Basque Research and Technology Alliance) ;
Pérez-Castro, Miguel A. (Basque Research and Technology Alliance) ;
González-Miranda, Ezequiel (Basque Research and Technology Alliance) ;
Piñeiro, Patricia (Basque Research and Technology Alliance) ;
Fernández-Veiga, Leire (Basque Research and Technology Alliance) ;
Galarza-Ahumada, Josu (Basque Research and Technology Alliance) ;
Fernández-Muñoz, Eva (Basque Research and Technology Alliance) ;
Pérez de Nanclares, Guiomar (Hospital Universitario de Araba Molecular (Epi)Genetics Laboratory) ;
Telling, Glenn (Colorado State University. Prion Research Center) ;
Geijo, Maria V (NEIKER-Basque Institute for Agricultural Research and Development) ;
Jiménez-Osés, Gonzalo (Basque Foundation for Science) ;
Castilla, Joaquín (Basque Foundation for Science)
Prion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein (PrP C) into a pathogenic form (PrP Sc). This process, despite being the central event underlying these disorders, remains largely unknown at a molecular level, precluding the prediction of new potential outbreaks or interspecies transmission incidents. [...]
2024 - 10.1038/s41467-024-46360-2
Nature communications, Vol. 15 (march 2024)
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3.
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18 p, 2.2 MB |
Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection
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Avila-Nieto, Carlos (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Vergara-Alert, Júlia (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Amengual-Rigo, Pep (Barcelona Supercomputing Center) ;
Ainsua-Enrich, Erola (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Brustolin, Marco (Institute of Tropical Medicine. Present Address: Department of Biomedical Sciences) ;
Rodríguez de la Concepción, María Luisa (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pedreño-López, Núria (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rodon, Jordi (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Urrea, Víctor (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pradenas, Edwards (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Marfil, Sílvia (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ballana, Ester (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Riveira-Muñoz, Eva (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Pérez, Mònica (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Roca, Núria (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Tarrés-Freixas, Ferran (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Cantero, Guillermo (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal) ;
Pons-Grífols, Anna (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Rovirosa, Carla (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Aguilar-Gurrieri, Carmen (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Ortiz, Raquel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Barajas Vélez, Ana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Trinité, Benjamin (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Lepore, Rosalba (Barcelona Supercomputing Center) ;
Muñoz-Basagoiti, Jordana (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Perez-Zsolt, Daniel (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa) ;
Izquierdo Useros, Nuria (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas) ;
Valencia, Alfonso (Universitat de Vic - Central de Catalunya) ;
Blanco, Julià (Universitat de Vic - Central de Catalunya) ;
Guallar, Victor (Institució catalana de Recerca i Estudis Avançats) ;
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol) ;
Segalés Coma, Joaquim (Universitat Autònoma de Barcelona. Departament de Sanitat i Anatomia Animals) ;
Carrillo, Jorge (Centro de Investigación Biomédica en Red de Enfermedades Infecciosas)
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version of the Spike glycoprotein [K986P/V987P (S-2P)] with improved stability, yield and immunogenicity. [...]
2024 - 10.1038/s41467-024-46714-w
Nature communications, Vol. 15 (march 2024)
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4.
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6 p, 1.2 MB |
Rational design of a neutral pH functional and stable organic photocathode
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Francàs Forcada, Laia (Imperial College London. Department of Chemistry) ;
Burns, Eric (Imperial College London. Department of Chemistry) ;
Steier, Ludmilla (Imperial College London. Department of Chemistry) ;
Cha, Hyojung (Imperial College London. Department of Chemistry) ;
Solà-Hernández, Lluís (Universitat Autònoma de Barcelona. Departament de Química) ;
Li, Xiaoe (Imperial College London. Department of Chemistry) ;
Tuladhar, Pabitra Shakya (Imperial College London. Department of Chemistry) ;
Bofill Arasa, Roger (Universitat Autònoma de Barcelona. Departament de Química) ;
García-Antón, Jordi (Universitat Autònoma de Barcelona. Departament de Química) ;
Sala Román, Xavier (Universitat Autònoma de Barcelona. Departament de Química) ;
Durrant, James R. (Imperial College London. Department of Chemistry)
In this work we lay out design guidelines for catalytically more efficient organic photocathodes achieving stable hydrogen production in neutral pH. We propose an organic photocathode architecture employing a NiO hole selective layer, a PCDTBT:PCBM bulk heterojunction, a compact TiO2 electron selective contact and a RuO2 nanoparticle catalyst. [...]
2018 - 10.1039/c8cc01736k
Chemical communications, Vol. 54, Issue 45 (June 2018) , p. 5732-5735
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5.
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14 p, 4.5 MB |
The Miocene primate Pliobates is a pliopithecoid
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Bouchet, Florian (Institut Català de Paleontologia Miquel Crusafont) ;
Zanolli, Clément (Université de Bordeaux) ;
Urciuoli, Alessandro (Institut Català de Paleontologia Miquel Crusafont) ;
Almécija, Sergio (Institut Català de Paleontologia Miquel Crusafont) ;
Fortuny, Josep (Institut Català de Paleontologia Miquel Crusafont) ;
Robles, Josep M. (Institut Català de Paleontologia Miquel Crusafont) ;
Beaudet, Amélie (University of the Witwatersrand) ;
Moyà Solà, Salvador (Universitat Autònoma de Barcelona. Departament de Biologia Animal, de Biologia Vegetal i d'Ecologia) ;
Alba, David M. (Institut Català de Paleontologia Miquel Crusafont)
The systematic status of the small-bodied catarrhine primate Pliobates cataloniae, from the Miocene (11. 6 Ma) of Spain, is controversial because it displays a mosaic of primitive and derived features compared with extant hominoids (apes and humans). [...]
2024 - 10.1038/s41467-024-47034-9
Nature communications, Vol. 15 (April 2024) , art. 2822
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16 p, 3.7 MB |
An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma
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Davalos, Veronica (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Lovell, Claudia D. (New York University School of Medicine, USA) ;
Von Itter, Richard (New York University School of Medicine, USA) ;
Dolgalev, Igor (New York University Grossman School of Medicine, USA) ;
Agrawal, Praveen (New York University Grossman School of Medicine, USA) ;
Baptiste, Gillian (New York University Grossman School of Medicine, USA) ;
Kahler, David J. (New York University Grossman School of Medicine, USA) ;
Sokolova, Elena (New York University Grossman School of Medicine, USA) ;
Moran, S (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Piqué, Laia (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Vega-Saenz de Miera, Eleazar (New York University School of Medicine, USA) ;
Fontanals-Cirera, Barbara (New York University School of Medicine, USA) ;
Karz, Alcida (New York University School of Medicine, USA) ;
Tsirigos, Aristotelis (New York University Grossman School of Medicine, USA) ;
Yun, Chi (New York University Grossman School of Medicine, USA) ;
Darvishian, Farbod (New York University Grossman School of Medicine, USA) ;
Etchevers, Heather C. (Aix-Marseille University, Marseille, France) ;
Osman, Iman (New York University Grossman School of Medicine, USA) ;
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Schober, Markus (New York University School of Medicine, USA) ;
Hernando, Eva (New York University Grossman School of Medicine, USA)
Metastatic melanoma develops once transformed melanocytic cells begin to de-differentiate into migratory and invasive melanoma cells with neural crest cell (NCC)-like and epithelial-to-mesenchymal transition (EMT)-like features. [...]
2023 - 10.1038/s41467-023-36967-2
Nature communications, Vol. 14 Núm. 1 (april 2023)
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9.
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15 p, 3.7 MB |
Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance
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Botta, Cirino (Clínica Universidad de Navarra) ;
Perez, Cristina (Clínica Universidad de Navarra) ;
Larrayoz, Marta (Clínica Universidad de Navarra) ;
Puig, Noemí (Hospital Universitario de Salamanca) ;
Cedena, María Teresa (Hospital Universitario 12 de Octubre) ;
Termini, Rosalinda (Clínica Universidad de Navarra) ;
Goicoechea, Ibai (Clínica Universidad de Navarra) ;
Rodriguez, Sara (Clínica Universidad de Navarra) ;
Zabaleta, Aintzane (Clínica Universidad de Navarra) ;
Lopez, Aitziber (Clínica Universidad de Navarra) ;
Sarvide, Sarai (Clínica Universidad de Navarra) ;
Blanco, Laura (Clínica Universidad de Navarra) ;
Papetti, Daniele Marco (Department of Informatics. University of Milano-Bicocca) ;
Nobile, M.S. (Biostatistics and Bioimaging Centre-B4) ;
Besozzi, Daniela (Biostatistics and Bioimaging Centre-B4) ;
Gentile, Massimo (Department of Oncohematology. "Annunziata" Hospital) ;
Correale, Pierpaolo (Great Metropolitan Hospital "Riuniti" of Reggio Calabria) ;
Siragusa, Sergio (Department of Health Promotion. University of Palermo) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
González-Garcia, Maria Esther (Hospital Universitario de Cabueñes (Gijón)) ;
Sureda, Anna (Institut d'Investigació Biomèdica de Bellvitge) ;
de Arriba, Felipe (Instituto Murciano de Investigación Biosanitaria) ;
Ríos-Tamayo, Rafael (Hospital Universitario Puerta de Hierro Majadahonda (Madrid)) ;
Moraleda, José María (Instituto Murciano de Investigación Biosanitaria) ;
Gironella, Mercedes (Hospital Universitari Vall d'Hebron) ;
Hernández, Miguel T. (Hospital Universitario de Canarias (Illes Canàries)) ;
Bargay, Joan (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears)) ;
Palomera, Luís (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza) ;
Pérez-Montaña, Albert (Hospital Universitari Son Espases (Illes Balears)) ;
Goldschmidt, Hartmut (Department of Internal Medicine V. University of Heidelberg) ;
Avet-Loiseau, Hervé (IUC-T Oncopole) ;
Roccaro, Aldo (Department of Hematology. ASST Spedali Civili di Brescia) ;
Orfao, Alberto (Universidad de Salamanca. Departament de Medicina) ;
Martinez-Lopez, Joaquín (Hospital Universitario 12 de Octubre) ;
Rosiñol, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Lahuerta, J. J (Hospital Universitario 12 de Octubre) ;
Bladé Creixenti, Juan (Institut d'Investigacions Biomèdiques August Pi i Sunyer) ;
Mateos, M. V (Hospital Universitario de SalamancaBiomedica de Salamanca (IBSAL). Centro de Investigación del Cancer (IBMCC-USAL. CSIC)) ;
San-Miguel, J (Clínica Universidad de Navarra) ;
Martinez Climent, Juan-José (Clínica Universidad de Navarra) ;
Paiva, Bruno (Clínica Universidad de Navarra)
Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). [...]
2023 - 10.1038/s41467-023-41562-6
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 5825
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15 p, 2.7 MB |
ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
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Mensali, Nadia (Department of Cellular Therapy. Oslo University Hospital) ;
Köksal, Hakan (Oslo University Hospital) ;
Joaquina, Sandy (Oslo University Hospital) ;
Wernhoff, Patrick (Oslo University Hospital) ;
Casey, Nicholas P. (Oslo University Hospital) ;
Romecín, Paola Alejandra (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Panisello, Carla (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Rodríguez, René (Instituto de Salud Carlos III) ;
Vimeux, Lene (Université de Paris) ;
Juzeniene, Asta (Oslo University Hospital) ;
Myhre, Marit R. (Oslo University Hospital) ;
Fåne, Anne (Oslo University Hospital) ;
Castilla-Ramirez, Carolina (Virgen del Rocio University Hospital) ;
Maggadottir, Solrun Melkork (Oslo University Hospital) ;
Duru, Adil Doganay (Nova Southeastern University) ;
Georgoudaki, Anna-Maria (Department of Oncology-Pathology. Karolinska Institutet) ;
Grad, Iwona (Oslo University Hospital) ;
Maturana, Andrés Daniel (Nagoya University) ;
Gaudernack, Gustav (Department of Cancer Immunology. Oslo University Hospital) ;
Kvalheim, Gunnar (Department of Cellular Therapy. Oslo University Hospital) ;
Carcaboso, Angel M. (Institut de Recerca Sant Joan de Déu) ;
De Álava, Enrique (Universidad de Sevilla) ;
Donnadieu, Emma (Université de Paris) ;
Bruland, Øyvind S (University of Oslo) ;
Menendez, Pablo (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Inderberg, Else Marit (Oslo University Hospital) ;
Wälchli, Sébastien (Oslo University Hospital)
Osteosarcoma (OS) remains a dismal malignancy in children and young adults, with poor outcome for metastatic and recurrent disease. Immunotherapies in OS are not as promising as in some other cancer types due to intra-tumor heterogeneity and considerable off-target expression of the potentially targetable proteins. [...]
2023 - 10.1038/s41467-023-39097-x
Nature communications, Vol. 14 Núm. 1 (december 2023) , p. 3375
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