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18 p, 862.2 KB |
Plain language summary of the MonumenTAL-1 study of talquetamab in people with relapsed or refractory multiple myeloma
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Chari, Ajai (Mount Sinai School of Medicine, USA) ;
Askari, Elham (Hospital Universitario Fundación Jiménez Díaz) ;
Caers, Jo (Centre Hospitalier Universitaire de Liège, Belgium) ;
Costa, Luciano J. (University of Alabama at Birmingham, USA) ;
Hilder, Brandi W. (Janssen Research & Development, Spring House, USA) ;
Krishnan, Amrita (City of Hope Comprehensive Cancer Center, Duarte, USA) ;
Mateos, M. V (Hospital Universitario de Salamanca) ;
Minnema, Monique C. (University Utrecht, Netherlands) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Pillarisetti, Kodandaram (Janssen Research & Development, Spring House, USA) ;
Van De Donk, Niels W.C.J. (Vrije Universiteit Amsterdam, Netherlands) ;
Rodríguez-Otero, Paula (Clínica Universidad de Navarra)
What is this summary about? This plain language summary describes the results of a phase 1 research study (or clinical trial) called MonumenTAL-1 published in the New England Journal of Medicine in December 2022. [...]
2023 -  10.2217/fon-2023-0332
Future oncology (London, England), Vol. 19 Núm. 27 (september 2023) , p. 1823-1840
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11 p, 1.9 MB |
Many people with chronic lymphocytic leukemia or small lymphocytic lymphoma benefit from ibrutinib treatment up to 8 years : a plain language summary
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Barr, Paul M. (University of Rochester Medical Center, USA) ;
Owen, Carolyn (University of Calgary, Canada) ;
Robak, Tadeusz (Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland) ;
Tedeschi, Alessandra (ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy) ;
Bairey, Osnat (Rabin Medical Center, Petah Tikva, Israel) ;
Burger, Jan A (University of Texas MD Anderson Cancer Center, Houston, USA) ;
Hillmen, Peter (The Leeds Teaching Hospitals, St James Institute of Oncology, Leeds, UK) ;
Dearden, Claire (The Royal Marsden Hospital, London, UK) ;
Grosicki, Sebastian (Silesian Medical University, Katowice, Poland) ;
McCarthy, Helen (Royal Bournemouth General Hospital (Dorset, Regne Unit)) ;
Li, Jian Yong (Jiangsu Province Hospital, Nanjing, China) ;
Offner, Fritz (Universitair Ziekenhuis Gent, Belgium) ;
Moreno, Carol (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Jermain, Mandy (Pharmacyclics LLC, an AbbVie Company, South San Francisco, USA) ;
Zhou, Cathy (Pharmacyclics LLC, an AbbVie Company, South San Francisco, USA) ;
Hsu, Emily (Pharmacyclics LLC, an AbbVie Company, South San Francisco, USA) ;
Szoke, Anita (Pharmacyclics LLC, an AbbVie Company, South San Francisco, USA) ;
Kipps, Thomas J. (UCSD Moores Cancer Center, San Diego, USA) ;
Ghia, Paolo (Università Vita-Salute San Raffaele &IRCCS Ospedale San Raffaele, Milan, Italy)
What is this summary about? This is a plain language summary of a publication describing long-term results from the RESONATE-2 study with up to 8 years of follow-up. The original paper was published in Blood Advances in June 2022. [...]
2022 - 10.2217/fon-2022-0898
Future oncology (London, England), Vol. 18 Núm. 37 (january 2022)
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8 p, 1.0 MB |
Plain language summary of the MajesTEC-1 study of teclistamab for the treatment of people with relapsed or refractory multiple myeloma
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Moreau, Philippe (University Hospital Hôtel-Dieu) ;
Van De Donk, Niels WCJ (Department of Hematology. Amsterdam University Medical Center) ;
Nahi, Hareth (Karolinska University Hospital and Karolinska Institutet (Suècia)) ;
Oriol, Albert (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ;
Nooka, Ajay K (Winship Cancer Institute. Emory University) ;
Martin, Thomas (University of California San Francisco) ;
Rosinol, Laura (Hospital Clínic i Provincial de Barcelona) ;
Karlin, Lionel (Centre Hospitalier Lyon Sud) ;
Benboubker, Lotfi (Hôpital Bretonneau) ;
Mateos, Maria-Victoria (University Hospital de Salamanca) ;
Popat, Rakesh (University College London Hospitals) ;
Martínez-López, Joaquín (Hospital Universitario 12 de Octubre (Madrid)) ;
Sidana, Surbhi (Stanford University of Medicine) ;
Delforge, Michele (University of Leuven) ;
Pei, Lixia (Janssen Research & Development) ;
Trancucci, Danielle (Janssen Research & Development) ;
Olyslager, Yunsi (Janssen Research & Development) ;
Uhlar, Clarissa (Janssen Research & Development) ;
Stephenson, Tara (Janssen Research & Development) ;
Rampelbergh, Rian Van (Janssen Research & Development) ;
Banerjee, Arnob (Janssen Research & Development) ;
Kobos, Rachel (Janssen Research & Development) ;
Usmani, Saad Z (Levine Cancer Institute-Atrium Health)
What is this summary about? This is a summary of a phase 1-2 clinical trial called MajesTEC-1. This trial tested the cancer drug teclistamab in people with relapsed or refractory multiple myeloma, a cancer that forms in a certain type of white blood cells known as plasma cells. [...]
2023 - 10.2217/fon-2023-0171
Future oncology (London, England), Vol. 19 Núm. 12 (january 2023) , p. 811-818
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10 p, 398.9 KB |
Summary of the international clinical guidelines for the management of hospital-acquired and ventilator-acquired pneumonia
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Torres, Antoni (Hospital Clínic i Provincial de Barcelona) ;
Niederman, Michael S. (Weill Cornell Medicine) ;
Chastre, Jean (Groupe Hospitalier Pitié-Salpêtrière) ;
Ewig, Santiago (Kliniken für Pneumologie und Infektiologie) ;
Fernandez-Vandellos, Patricia (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Hanberger, Hakan (Linköping University) ;
Kollef, Marin (Washington University School of Medicine) ;
Bassi, Gianluigi L. (Hospital Clínic i Provincial de Barcelona) ;
Luna, Carlos M. (Hospital de Clínicas "José de San Martin") ;
Martin-Loeches, Ignacio (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias) ;
Paiva, J.Artur (University of Porto Medical School) ;
Read, Robert C. (NIHR Southampton Biomedical Research Centre. University Hospital Southampton) ;
Rigau, David (Institut d'Investigació Biomèdica Sant Pau) ;
Timsit, Jean François (Paris Diderot University and Bichat Hospital) ;
Welte, Tobias (Medizinische Hoschschule Hannover and German Center of Lung Research (DZL)) ;
Wunderink, Richard (Northwestern University Feinberg School of Medicine) ;
Universitat Autònoma de Barcelona
A summary of the evidence and recommendations made in the ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia http://ow. ly/S3zA30iZfLa.
2018 - 10.1183/23120541.00028-2018
ERJ Open Research, Vol. 4 Núm. 2 (january 2018) , p. 28-2018
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9 p, 1.5 MB |
The use of lumbar puncture and safety recommendations in Alzheimer's disease : a plain language summary
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Hampel, Harald (Eisai Inc. Neurology Business Group) ;
Elhage, Aya (Eisai Inc. Neurology Business Group) ;
Shaw, Leslie M. (Perelman School of Medicine. Department of Pathology & Laboratory Medicine. University of Pennsylvania) ;
Aisen, Paul (Usc Alzheimer's Therapeutic Research Institute) ;
Chen, Christopher (Memory Aging & Cognition Centre. Departments of Pharmacology & Psychological Medicine. Yong Loo Lin School of Medicine. National University of Singapore) ;
Lleó, Alberto (Institut d'Investigació Biomèdica Sant Pau) ;
Iwatsubo, Takeshi (Department of Neuropathology. Graduate School of Medicine. The University of Tokyo) ;
Iwata, Atsushi (Tokyo Metropolitan Geriatric Hospital) ;
Yamada, Masahito (Department of Neurology & Neurological Science. Tokyo Medical & Dental University) ;
Ikeuchi, Takeshi (Department of Molecular Genetics. Brain Research Institute. Niigata University) ;
Jia, Jianping (Innovation Center for Neurological Disorders. Department of Neurology. Xuan Wu Hospital. Capital Medical University) ;
Wang, Huali (Dementia Care & Research Center. Peking University Institute of Mental Health (Sixth Hospital). Beijing Dementia Key Lab. National Clinical Research Center for Mental Disorders) ;
Teunissen, Charlotte E. (Amsterdam University Medical Centers (AUMC)) ;
Peskind, Elaine (Va Northwest Mental Illness Research. Education & Clinical Center. Va Puget Sound Health Care System. Department of Psychiatry & Behavioral Sciences. University of Washington School of Medicine) ;
Blennow, Kaj (Clinical Neurochemistry Laboratory. Sahlgrenska University Hospital) ;
Cummings, Jeffrey (Chambers-Grundy Center for Transformative Neuroscience. Department of Brain Health. School of Integrated Health Sciences. University of Nevada Las Vegas (UNLV)) ;
Vergallo, Andrea (Eisai Inc. Neurology Business Group) ;
Universitat Autònoma de Barcelona
What is this summary about? This is a plain language summary of an article published in Alzheimer's & Dementia. It looks at a type of test called a lumbar puncture (also known as spinal tap) used in people suspected of having Alzheimer's disease or some other form of dementia. [...]
2022 - 10.2217/nmt-2022-0012
Neurodegenerative Disease Management, Vol. 12 Núm. 5 (january 2022) , p. 221-229
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4 p, 983.4 KB |
Executive summary on the treatment of type 2 diabetes mellitus in elderly or frail individuals. 2022 update of the 2018 consensus document "Treatment of type 2 diabetes mellitus in the elderly" Resumen ejecutivo sobre el tratamiento de la diabetes mellitus tipo 2 en personas de edad avanzada o frágiles. Actualización 2022 del documento de consenso 2018 «Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano»
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Gómez-Peralta, Fernando (Hospital General de Segovia. Unidad de Endocrinología y Nutrición) ;
Carrasco-Sánchez, Francisco Javier (Hospital General Juan Ramón Jiménez. Servicio de Medicina Interna) ;
Pérez Pérez, Antonio (Institut d'Investigació Biomèdica Sant Pau) ;
Escalada, J. (Clínica Universitaria de Navarra. Departamento de Endocrinología y Nutrición) ;
Álvarez-Guisasola, F. (Centro de Salud Ribera del Órbigo. León. Grupo de Trabajo de Diabetes. Sociedad Española de Medicina de Familia y Comunitaria (semFYC)) ;
Miranda-Fernández-Santos, C. (Centro de Salud Buenavista Toledo. Toledo. Área Cardiovascular y Diabetes de la Sociedad Española de Médicos Generales y de Familia (SEMG)) ;
Mediavilla-Bravo, J.J. (Centro de Salud Burgos Rural. Burgos. Sociedad Española de Médicos de Atención Primaria (SEMERGEN)) ;
Gómez-Huelgas, R. (Instituto de Investigación Biomédica de Málaga) ;
Universitat Autònoma de Barcelona
The population with type 2 DM (DM2) is highly heterogeneous, representing an important challenge for healthcare professionals. The therapeutic choice should be individualized, considering the functional status, frailty, the occurrence of comorbidities, and the preferences of patients and their caregivers. [...]
2022 - 10.1016/j.rce.2022.03.004
Revista Clinica Espanola, Vol. 222 Núm. 8 (octubre 2022) , p. 496-499
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9 p, 1.3 MB |
A plain language summary of results from the ADAURA study : osimertinib after surgery for patients who have early-stage EGFR-mutated non-small cell lung cancer
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Wu, Yi-Long (Guangdong Lung Cancer Institute. Guangdong Provincial People's Hospital. Guangdong Academy of Medical Sciences) ;
Tsuboi, M. (Department of Thoracic Surgery and Oncology. National Cancer Center Hospital East) ;
John, T. (Department of Medical Oncology. Austin Health) ;
Grohe, C. (Department of Respiratory Diseases. Evangelische Lungenklinik) ;
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau) ;
Goldman, J.W. (David Geffen School of Medicine. University of California) ;
Laktionov, K. (Center of Innovative Technologies and Oncology. N.N. Blokhin Russian Cancer Center. Russian Academy of Medical Sciences) ;
Kim, S.W. (Department of Oncology. Asan Medical Center. University of Ulsan. College of Medicine) ;
Kato, T. (Department of Thoracic Oncology. Kanagawa Cancer Center) ;
Vu, H.V. (Department of Thoracic Surgery. Choray Hospital) ;
Lu, S. (Lung Cancer Center. Shanghai Chest Hospital. Shanghai Jiao Tong University) ;
Lee, K.Y. (Precision Medicine. Lung Cancer Center. Konkuk University. Medical Center) ;
Akewanlop, C. (Division of Medical Oncology. Faculty of Medicine. Siriraj Hospital) ;
Yu, C.J. (Department of Internal Medicine. National Taiwan University. Hospital Hsinchu Branch. National Taiwan University. College of Medicine) ;
De Marinis, Filippo (Thoracic Oncology Division. European Institute of Oncology (IEO). IRCCS) ;
Bonanno, Laura (Medical Oncology 2. Istituto Oncologico Veneto IOV IRCCS) ;
Dómine Gómez, Manuel (Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz) ;
Shepherd, F.A. (Department of Medical Oncology and Hematology. University Health Network. Princess Margaret Hospital. University of Toronto) ;
Zeng, L. (Late Oncology Statistics. AstraZeneca) ;
Hodge, R. (Late Oncology Statistics. AstraZeneca) ;
Atasoy, A. (Late Oncology Research and Development. AstraZeneca) ;
Rukazenkov, Y. (Late Oncology Research and Development. AstraZeneca) ;
Herbst, Roy S (Medical Oncology. Yale School of Medicine. Yale Cancer Center)
Here, we summarize the initial results from the ADAURA clinical study looking at treatment with osimertinib in patients with a specific type of non-small cell lung cancer (also called NSCLC). Osimertinib (TAGRISSO®) is a medication used to treat a type of NSCLC with a change (mutation) in the EGFR gene, known as EGFR-mutated NSCLC. [...]
2021 - 10.2217/fon-2021-0752
Future oncology (London, England), Vol. 17 Núm. 35 (december 2021) , p. 4827-4835
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9 p, 938.4 KB |
Conducting clinical trials in persons with Down syndrome : summary from the NIH INCLUDE Down syndrome clinical trials readiness working group
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Baumer, Nicole (Boston Children's Hospital (Boston, Estats Units d'Amèrica)) ;
Becker, Mara L. (Duke University School of Medicine) ;
Capone, George (The Johns Hopkins School of Medicine) ;
Egan, Kathleen (Parent/Advocate, Virginia, USA) ;
Fortea, Juan (Institut d'Investigació Biomèdica Sant Pau) ;
Handen, Benjamin L. (University of Pittsburgh) ;
Head, Elizabeth (University of California) ;
Hendrix, James E. (LuMind IDSC Foundation, Burlington, USA) ;
Litovsky, Ruth Y. (University of Wisconsin) ;
Strydom, Andre (King's College London) ;
Tapia, Ignacio E. (University of Pennsylvania) ;
Rafii, Michael S. (University of Southern California) ;
Universitat Autònoma de Barcelona
The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in clinical trials involving individuals with Down syndrome (DS). [...]
2022 - 10.1186/s11689-022-09435-z
Journal of Neurodevelopmental Disorders, Vol. 14 (march 2022)
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