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Institut de Biotecnologia i de Biomedicina (IBB)

The Institut de Biotecnologia i de Biomedicina (IBB) was created in 1970 as a research institute of the Universitat Autònoma de Barcelona (UAB). Although the institute was originally devoted to promoting fundamental biological research, we have been focusing in the Biotechnology and Biomedicine fields for the last 20 years.

At the IBB we conduct top-level scientific research with the aim of advancing scientific findings into translational results, to revert our knowledge to society. Our researchers participate in high competitive calls, both national and internationally, aimed at funding basic and translational research.

Among the over 200 researchers currently working at the IBB, there are lecturers and professors from the UAB, ICREA and other senior researchers, postdoctoral fellows, and PhD and Master students. The IBB hosts 18 research groups organised into 3 programmes covering different areas of scientific expertise that include bioinformatics, cellular and structural biology, genomics, immunology, microbiology and proteomics.

Our multidisciplinary character, one of the most relevant characteristics of the IBB, allows for a broad approach to biological problems, both basic and applied. The IBB researchers have expertise in several topics within the biomedicine and the biotechnology field.
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2025-11-19
06:48
15 p, 2.0 MB Exosome Biomarker Profiling Using a Paper-Based Vertical Flow Assay / Pallarès-Rusiñol, Arnau (Universitat Autònoma de Barcelona. Departament de Química) ; Marfà, Jennifer (Universitat Autònoma de Barcelona. Departament de Química) ; Rossi, Rosanna (Universitat Autònoma de Barcelona. Departament de Química) ; Martí, Mercè (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química)
Exosomes are nanoscale extracellular vesicles that carry valuable biomolecular information. However, their characterization still depends on complex and costly techniques such as flow cytometry. In this study, a paper-based Vertical Flow Assay (VFA) specifically designed for the detection and profiling of exosomes derived from metastatic breast cancer cell lines is presented. [...]
2025 - 10.3390/bios15100694
Biosensors, Vol. 15, Issue 10 (October 2025) , art. 694  
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2025-11-05
06:30
9 p, 3.3 MB Electrochemical biosensor for early Alzheimer's detection and patient risk stratification using plasma exosomes / Rossi, Rosanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Cano, Amanda (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Pallarès-Rusiñol, Arnau (Universitat Autònoma de Barcelona. Departament de Química) ; Ruiz Laza, Agustín (Ace Alzheimer Center Barcelona) ; Martí, Mercè (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química)
Alzheimer's Disease (AD) is the leading cause of dementia, accounting for 60-70 % of cases worldwide. Early diagnosis remains challenging due to the limitations of current diagnostic tools, which are costly, invasive, and suffer from low patient compliance. [...]
2026 - 10.1016/j.bios.2025.118061
Biosensors & bioelectronics, Vol. 292 (January 2026) , art. 118061  
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2025-10-28
14:35
16 p, 2.6 MB Multivalent Protein Nanorings for Broad and Potent SARS-CoV-2 Neutralization / Behbahanipour, Molood (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Goldin, Carla (Consejo Nacional de Investigaciones Científicas y Técnicas (Argentina)) ; Prato, Cecilia Arahi (Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas (Argentina)) ; Paletta, Ana Luz (Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas (Argentina)) ; Bárcenas, Oriol (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Navarro, Susanna (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pujols, Jordi (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Murgida, Daniel H. (Universidad de Buenos Aires. Departamento de Química Inorgánica, Analítica y Química Física) ; Tribulatti, María Virginia (Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas (Argentina)) ; Esperante, Sebastián (Consejo Nacional de Investigaciones Científicas y Técnicas) ; Alvarez-Paggi, Damian (Consejo Nacional de Investigaciones Científicas y Técnicas) ; Ventura, Salvador (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
The ongoing threat of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the limitations of conventional antibody-based therapeutics (ABTs) underscore the need for scalable and customizable antiviral platforms. [...]
2025 - 10.1002/adhm.202503487
Advanced Healthcare Materials, (October 2025) , art. e03487  
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2025-10-23
06:13
27 p, 13.6 MB A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formation / Burgos-Ruiz, Ana María (Universidad Pablo de Olavide) ; Geng, Fan-Suo (Garvan Institute of Medical Research (Sydney, Australia)) ; Pujol Infantes, Gala (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Sanabria, Estefanía (Universidad Pablo de Olavide) ; Brethouwer, Thirsa (Universidad Pablo de Olavide) ; Almuedo-Castillo, María (Universidad Pablo de Olavide) ; Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Tena, Juan J. (Universidad Pablo de Olavide) ; Bogdanovic, Ozren (University of New South Wales (Sidney, Australia))
Spermatogenesis is the biological process by which male sperm cells (spermatozoa) are produced in the testes. Beyond facilitating the transmission of genetic information, spermatogenesis also provides a potential framework for inter- and transgenerational inheritance of gene-regulatory states. [...]
2025 - 10.1038/s44320-025-00157-7
Molecular systems biology, Vol.21, Issue 10 (October 2025)  
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2025-10-23
06:13
15 p, 2.0 MB Male meiosis at the helm : shaping genomes and sex chromosomes in emerging vertebrate models / Marin Gual, Laia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Waters, Paul D (School of Biotechnology and Biomolecular Sciences) ; Ruiz-Herrera Moreno, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
The generation of haploid gametes is a hallmark of sexual reproduction achieved through a complex, albeit tightly regulated, reductional cell division known as meiosis. While the molecular underpinnings of meiosis have been extensively characterized in eutherian mammalian models, key aspects-particularly those governing chromosome synapsis and recombination-remain poorly understood in non-eutherian mammals and non-model vertebrates. [...]
2025 - 10.1093/biolre/ioaf175
Biology of reproduction, (July 2025) , art. ioaf175  
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2025-10-21
08:21
18 p, 4.4 MB Signaling pathways contributing to the transcriptional response to alkalinization in Komagataella phaffii : role of the transcription factors Crz1 and Rim101 / Albacar, Marcel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Casamayor Gracia, Antonio (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Zekhnini, Abdelghani ; Schmidt, Alexander ; Gonzalez Sevine, Asier (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ariño Carmona, Joaquín (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Promoters able to respond to moderate alkalinization in the industrially relevant yeast Komagataella phaffii have been proposed as a tool for the design of novel methanol-free platforms for heterologous protein expression. [...]
2025 - 10.1038/s41598-025-20192-6
Scientific reports, Vol. 15 (2025) , p. 35841  
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2025-10-21
06:05
15 p, 7.3 MB Structural information in therapeutic peptides : Emerging applications in biomedicine / Iglesias, Valentin (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Bárcenas, Oriol (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pintado-Grima, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Burdukiewicz, Michał (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Peptides are attracting a growing interest as therapeutic agents. This trend stems from their cost-effectiveness and reduced immunogenicity, compared to antibodies or recombinant proteins, but also from their ability to dock and interfere with large protein-protein interaction surfaces, and their higher specificity and better biocompatibility relative to organic molecules. [...]
2024 - 10.1002/2211-5463.13847
FEBS Open Bio, Vol. 15, Issue 2 (February 2025) , p. 254-268  
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2025-10-07
09:05
12 p, 8.0 MB Self-disintegrating protein-leaking microparticles for topical protein delivery / Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Sanchez, Julieta M. (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; de Pinho Favaro, Marianna T (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Martínez-Cuentra, Genís Josep (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Contreras, Estefania (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Di Somma, Angela (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; López-Laguna, Hèctor (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Casanova Rigat, Isolda (Institut de Recerca Sant Pau) ; Mangues, Ramon 1957- (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Vázquez Gómez, Esther (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Advanced drug delivery systems, if engineered to enhance drug stability and extend its kinetic bioavailability, are expected to expand the spectrum of local therapeutic approaches for dermatological conditions. [...]
2025 - 10.1016/j.ijbiomac.2025.147730
International journal of biological macromolecules, Vol. 329, Part 1 (November 2025) , art. 147730  
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2025-09-30
07:39
24 p, 9.3 MB Post-testicular spermatozoa of a marine teleost can conduct de novo cytoplasmic and mitochondrial translation / Castro-Arnau, Júlia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Chauvigné, François (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; González, Asier (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Finn, Roderick Nigel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Carrascal Pérez, Montserrat (Institut de Recerca Biomèdica de Barcelona) ; Cerdà, Joan (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Translational silence of spermatozoa has long been considered the norm in animals. However, studies in mammals have shown that the mitochondrial ribosomal machinery is selectively activated during capacitation in the female reproductive tract, while cytosolic ribosomes remain inactive. [...]
2025 - 10.1016/j.isci.2024.111537
iScience, Vol. 28, Issue 1 (January 2025) , art. 111537  
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2025-07-30
10:16
26 p, 2.4 MB Targeting the chemokine receptor CXCR4 for cancer therapies / Rueda, Ariana (Institut de Recerca Sant Pau) ; Serna, Naroa (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Mangues, Ramon 1957- (Institut de Recerca Sant Pau) ; Villaverde Corrales, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Unzueta Elorza, Ugutz (Institut de Recerca Sant Pau)
The C-X-C chemokine receptor type 4 (CXCR4) has emerged as a key molecular biomarker for cancer therapies due to its critical role in tumor progression and metastases by displaying a stem cells phenotype. [...]
2025 - 10.1186/s40364-025-00778-y
Biomarker Research, Vol. 13 Núm. 1 (december 2025) , p. 68  
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