2026-07-03
14:12 |
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2026-06-16
19:12 |
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2026-06-29
14:12 |
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10 p, 4.3 MB |
Sex chromosome dosage compensation in a sex reversing skink is not influenced by sexual phenotype
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Hanrahan, Benjamin J. (University of New South Wales (Sydney, Austràlia)) ;
Chang, J. King (University of New South Wales (Sydney, Austràlia)) ;
Milton, Ashley M. (University of New South Wales (Sydney, Austràlia)) ;
Lister, Nicholas (University of New South Wales (Sydney, Austràlia)) ;
Dissanayake, Duminda S.B. (University of Canberra) ;
Hammond, Jillian M. (Murdoch Children's Research Institute) ;
Reis, Andre L.M. (University of New South Wales (Sydney, Austràlia)) ;
Deveson, Ira W. (University of New South Wales (Sydney, Austràlia)) ;
Ruiz-Herrera, Aurora (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Patel, Hardip R. (Australian National University) ;
Graves, Jennifer A.Marshall (La Trobe University) ;
Georges, Arthur (University of Canberra) ;
Waters, Paul D. (University of New South Wales (Sydney, Austràlia)) ;
Universitat Autònoma de Barcelona.
Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia
Background: Lizards have sex determination systems that can differ between even closely related species. These include XY and ZW systems, and thermolabile systems where genes and temperature interact to determine sex. [...]
2026 -  10.1186/s12864-025-12217-1
BMC genomics, Vol. 27, Num. 1 (December 2026) , art. 72
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2026-06-23
19:13 |
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16 p, 5.7 MB |
Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate
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Sánchez-Osuna, Miquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Bierge, Paula (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gómez Sánchez, Inmaculada (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Guitart Matas, Judith (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Monsálvez, Víctor (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Rabanal, Patricia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Pereira, Ana P. (Universidade do Porto) ;
Freitas, Ana R. (Universidade do Porto) ;
Peixe, Luisa (Universidade do Porto) ;
Espasa, Mateu (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Gasch Blasi, Oriol (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Novais, Carla (Universidade do Porto) ;
Pich, Oscar Q. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Enterococcus faecium exhibits intrinsic resistance to cephalosporins (CPHs), yet the genetic determinants of this phenotype remain incompletely understood. To date, E. faecium strains with low minimum inhibitory concentrations (MICs) of CPH have only been described following genetic manipulation. [...]
2026 - 10.1128/aac.01948-25
Antimicrobial Agents and Chemotherapy, Vol. 70, Num. 5 (May 2026) , art. e01948-25
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2026-06-18
17:12 |
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16 p, 7.0 MB |
Chromosome-Level Genomics and Historical Museum Collections Reveal New Insights Into the Population Structure and Chromosome Evolution of Waterbuck
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Kirkland, Corey (University of Kent) ;
Wang, Xi (University of Copenhagen) ;
Canedo-Ribeiro, Carla (University of Kent) ;
Álvarez-González, Lucía (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Weisz, David (The Center for Genome Architecture. Baylor College of Medicine) ;
Mena, Alexandria (SeaWorld San Diego) ;
St Leger, Judy (Cornell University College of Veterinary Medicine) ;
Dudchenko, Olga (Rice University) ;
Lieberman Aiden, Erez (Rice University) ;
Ruiz-Herrera, Aurora (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia) ;
Heller, Rasmus (University of Copenhagen) ;
King, Tony (University of Kent) ;
Farré, Marta (University of Kent)
Advances in sequencing and chromosome-scale assembly have brought non-model animals into focus, deepening our understanding of genome and chromosome evolution. Here, we present the waterbuck (Kobus ellipsiprymnus) as an emerging model antelope for studying population dynamics and chromosome evolution. [...]
2026 - 10.1111/mec.70218
Molecular ecology, Vol. 35, Num. 1 (January 2026) , art. e70218
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2026-06-15
15:12 |
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9 p, 1.6 MB |
Engineered Mycoplasma pneumoniae targeting dual-species bacterial biofilms : a novel strategy against infections
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Mazzolini, Rocco (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Garrido, Victoria (Instituto de Agrobiotecnología) ;
Gómez, Andromeda-Celeste (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Collantes, María (Instituto de Investigación Sanitaria de Navarra) ;
Grilló, María Jesús (Instituto de Agrobiotecnología) ;
Piñero-Lambea, Carlos (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Gibert, Isidre (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Yero, Daniel (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Lluch-Senar, Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Antimicrobial resistance is a major global health threat, potentially causing 8. 22 million deaths annually by 2050. Polymicrobial biofilms significantly contribute to this crisis, leading to treatment failure, especially in chronic airway infections caused by Staphylococcus aureus and Pseudomonas aeruginosa, common in ventilator-associated pneumonia and cystic fibrosis. [...]
2025 - 10.1038/s41522-025-00835-2
npj biofilms and microbiomes, Vol. 11 (November 2025) , art. 208
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2026-06-15
16:13 |
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15 p, 15.9 MB |
Nanotoxin induces in situ pyroptosis to sensitize αPD1 to ablate metastases in microsattellite stable colorectal cancer
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Carrasco-Díaz, Luis M. (Institut de Recerca Sant Pau) ;
Otero-Mateo, Marc (Institut de Recerca Sant Pau) ;
Álamo, Patricia (Institut de Recerca Sant Pau) ;
Gallardo, Alberto (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Virgili Manrique, Anna Cristina (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Paez, David (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Voltà-Durán, Eric (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Villaverde, Antonio (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Vázquez, Esther (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Unzueta Elorza, Ugutz (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ;
Casanova Rigat, Isolda (Institut de Recerca Sant Pau) ;
Alba Castellón, Lorena (Institut de Recerca Sant Pau) ;
Mangues, Ramon 1957- (Institut de Recerca Sant Pau)
Nanomedicine has not generated anticancer immunotherapies because of insufficient targeted specificity, lack of immunity, and associated toxicity. We developed a T22-DITOX-H6 (TDX) nanotoxin to selectively release the diphtheria toxin in the cancer cells in immunosuppressed CXCR4-overexpressing (CXCR4 +) colorectal (CRC) models, inducing pyroptosis and anticancer effect. [...]
2025 - 10.1016/j.phrs.2025.107982
Pharmacological research, Vol. 221 (November 2025) , art. 107982
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2026-06-15
18:12 |
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8 p, 1.5 MB |
mGem : Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemic
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Sánchez-Osuna, Miquel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Buiatte, Ana Beatriz Garcez (University at Albany. Department of Biological Sciences) ;
Wang, Rebecca (Dartmouth-Hitchcock Medical Center) ;
Gasch Blasi, Oriol (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT)) ;
Martin, Isabella W. (Dartmouth-Hitchcock Medical Center) ;
Andam, Cheryl P. (University at Albany. Department of Biological Sciences) ;
Pich, Oscar Q. (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The pressure of the coronavirus disease 2019 (COVID-19) pandemic on global healthcare systems and societies was unprecedented in the modern era. Social restrictions, containment measures, and disruptions in antimicrobial prescriptions and consumption during the pandemic have been reported to alter the epidemiology of bacterial diseases, although these effects likely differed markedly between locations. [...]
2026 - 10.1128/mbio.03665-25
mBio, Vol. 17, Num. 5 (May 2026) , art. e03665-25
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2026-06-15
11:12 |
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20 p, 1.2 MB |
Nucleoside binding by a surface lipoprotein governs conjugative ICE acquisition in mycoplasmas
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Derriche, M'hamed (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Nouvel, Laurent Xavier (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Fauvet, Calvin (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Mach Casellas, Núria (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Simon, Elisa (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Pot, Gwendoline (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Robert, Hortensia (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Stella, Alexandre (Université de Toulouse. Institut de Pharmacologie et de Biologie Structurale) ;
De la Fe, Christina (Universidad de Murcia. Departamento de Sanidad Animal) ;
Maillard, Renaud (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Torres Puig, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Arfi, Yonathan (Université de Bordeaux. L’Institut national de recherche pour l'agriculture, l'alimentation et l'environnement) ;
Citti. Christine (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Baranowski, Eric (Université de Toulouse. Laboratoire Interactions Hôtes-Agents Pathogènes) ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
Integrative and conjugative elements (ICEs) are major mediators of horizontal gene transfer in bacteria. However, the role of recipient cells in their acquisition has received little attention. Using the ruminant pathogens Mycoplasma agalactiae and Mycoplasma bovis as minimal models, we combined genome-wide transposon mutagenesis with high-throughput mating assays to identify recipient factors required for ICE acquisition. [...]
2026 - 10.1128/mbio.02939-25
mBio, Vol. 17, Num. 2 (February 2026) , art. e02939-25
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2026-06-15
11:12 |
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17 p, 2.5 MB |
A versatile plug and play bacterial chassis based on a fast-growing Mycoplasma species
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Inäbnit, Jana (University of Bern. Department of Infectious Diseases and Pathobiology) ;
Démoulins, Thomas (University of Bern. Department of Infectious Diseases and Pathobiology) ;
Pramateftaki, Paraskevi (University of Bern. Department of Infectious Diseases and Pathobiology) ;
Bourgeon, Marilou (University of Bern. Department of Infectious Diseases and Pathobiology) ;
Labroussaa, Fabien (University of Bern. Department of Infectious Diseases and Pathobiology) ;
Jores, Jörg (University of Bern. Department of Infectious Diseases and Pathobiology) ;
Torres Puig, Sergi (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ;
Universitat Autònoma de Barcelona.
Departament de Bioquímica i de Biologia Molecular
An easy engineerable bacterial chassis opens a spectrum of biomedical applications such as antigen or drug delivery. However, most cell-walled bacteria are readily recognized and cleared by the immune system and encode various effector proteins potentially interacting with the target species. [...]
2025 - 10.1093/nar/gkaf1134
Nucleic acids research, Vol. 53, Num. 20 (November 2025) , art. gkaf1134
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