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Institut de Biotecnologia i de Biomedicina (IBB)

The Institut de Biotecnologia i de Biomedicina (IBB) was created in 1970 as a research institute of the Universitat Autònoma de Barcelona (UAB). Although the institute was originally devoted to promoting fundamental biological research, we have been focusing in the Biotechnology and Biomedicine fields for the last 20 years.

At the IBB we conduct top-level scientific research with the aim of advancing scientific findings into translational results, to revert our knowledge to society. Our researchers participate in high competitive calls, both national and internationally, aimed at funding basic and translational research.

Among the over 200 researchers currently working at the IBB, there are lecturers and professors from the UAB, ICREA and other senior researchers, postdoctoral fellows, and PhD and Master students. The IBB hosts 18 research groups organised into 3 programmes covering different areas of scientific expertise that include bioinformatics, cellular and structural biology, genomics, immunology, microbiology and proteomics.

Our multidisciplinary character, one of the most relevant characteristics of the IBB, allows for a broad approach to biological problems, both basic and applied. The IBB researchers have expertise in several topics within the biomedicine and the biotechnology field.
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2026-01-14
18:10
43 p, 1.8 MB Deciphering the Molecular Details of the Lipoxin Formation Mechanism in the 5(S),15(S)-DiHpETE Biosynthetic Pathway Catalyzed by Reticulocyte 15-Lipoxygenase-1 / Cruz Saez, Alejandro (Universitat Autònoma de Barcelona. Departament de Química) ; González-Lafont, Àngels (Universitat Autònoma de Barcelona. Departament de Química) ; Lluch López, Josep Maria (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Chronic inflammation is now widely recognized to play important roles in many commonly occurring diseases, including COVID-19. The resolution response to this chronic inflammation is an active process governed by specialized pro-resolving mediators (SPMs) like the lipid mediators known as lipoxins. [...]
2020 - 10.1021/acs.jpcb.0c09147
Journal of physical chemistry B, Vol. 124, Num. 50 (December 2020) , p. 11406-11418  
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2026-01-08
17:10
5 p, 1011.8 KB Metagenomic survey reveals Volzhskoe tick virus in Hyalomma ticks for the first time in western Europe, North-Eastern Spain / Carrera Faja, Laura (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals) ; Jasso, Mariette Viladomat (Universitat Autònoma de Barcelona. Centre de Recerca en Sanitat Animal) ; Sarmiento, Iris (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Cabrera Gumbau, Jordi Manuel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Espunyes, Johan (Govern d'Andorra. Ministeri de Medi Ambient, Agricultura i Ramaderia) ; Martinez-Urtaza, Jaime (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia) ; Cabezón Ponsoda, Óscar (Unitat mixta d'investigació IRTA-UAB en Sanitat Animal. Centre de Recerca en Sanitat Animal)
Ticks are reservoirs and vectors of several emerging arboviruses, yet their associated virome remains poorly characterized. Using meta-transcriptomic sequencing, we surveyed Hyalomma marginatum and Rhipicephalus bursa ticks collected from areas with contrasting Crimean-Congo haemorrhagic fever virus (CCHFV) seroprevalence in wild ungulates in north-eastern Spain, a region with no reported CCHF cases in humans. [...]
2025 - 10.1016/j.onehlt.2025.101279
One Health, Vol. 21 (December 2025) , art. 101279  
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2026-01-14
16:10
12 p, 656.7 KB Effects of Chronic Cortisol Administration on Global Expression of GR and the Liver Transcriptome in Sparus aurata / Teles, Mariana (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Boltana, Sebastian (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Reyes Lopez, Felipe Esteban (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Santos, Monteiro Ana (University of Aveiro. Department of Biology & CESAM) ; Mackenzie, Simon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Tort Bardolet, Lluís (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia)
The present work was designed to assess the effects of artificially increased high plasma cortisol levels induced by slow-release cortisol implants on the mRNA abundance of the glucocorticoid receptor (GR) in different organs of Sparus aurata (Gilthead sea bream), as well as to evaluate global transcriptional changes in the liver, using the Aquagenomics S. [...]
2013 - 10.1007/s10126-012-9467-y
Marine Biotechnology, Vol. 15, Num. 1 (February 2013) , p. 104-114  
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2026-01-09
13:11
17 p, 455.3 KB Mass spectrometry footprinting reveals how kinetic stabilizers counteract transthyretin dynamics altered by pathogenic mutations / Garcia de Carvalho Pinheiro, Francisca (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Kant, Ravi (The George Washington University. Department of Chemistry) ; Chemuru, Saketh (The George Washington University. Department of Chemistry) ; Varejão, Nathalia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Velázquez-Campoy, Adrián (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Reverter Cendrós, David (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Gross, Michael L. (The George Washington University. Department of Chemistry) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
The aggregation of transthyretin (TTR) results in life-threatening transthyretin amyloidosis. Familial forms of the disease arise from point mutations that destabilize the TTR tetramer, leading to its dissociation and/or monomer unfolding and subsequent formation of amyloid fibrils. [...]
2025 - 10.1073/pnas.2519908122
Proceedings of the National Academy of Sciences of The United States Of America, Vol. 123, Num. 1 (desembre 2025) , art. e2519908122  
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2026-01-03
19:05
8 p, 554.3 KB Gene expression and TNF-alpha secretion profile in rainbow trout macrophages following exposures to copper and bacterial lipopolysaccharide / Teles, Mariana (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia) ; Mackenzie, Simon (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Boltana, Sebastian (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Callol Junyer, Agnès (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Tort Bardolet, Lluís (Universitat Autònoma de Barcelona. Departament de Biologia Cel.lular, de Fisiologia i d'Immunologia)
Fish macrophage function can be altered after exposure to pathogens as well as to xenobiotics. Considering that wild and farmed fish can be exposed in their habitats simultaneously to different types of stressors, including chemical contaminants (e. [...]
2011 - 10.1016/j.fsi.2010.11.006
Fish & shellfish immunology, Vol. 30, Num. 1 (January 2011) , p. 340-346  
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2026-01-09
10:10
17 p, 338.8 KB Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis / Garcia de Carvalho Pinheiro, Francisca (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Varejão, Nathalia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Esperante, Sebastián (INFANT Foundation) ; Santos, Jaime (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Velázquez-Campoy, Adrián (Universidad de Zaragoza. Departamento de Bioquímica y Biología Molecular y Celular) ; Reverter Cendrós, David (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pallarès i Goitiz, Irantzu (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Ventura, Salvador (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Hereditary transthyretin amyloidosis (ATTR) is a disease characterized by the extracellular deposition of transthyretin (TTR) amyloid fibrils. Highly destabilizing TTR mutations cause leptomeningeal amyloidosis, a rare, but fatal, disorder in which TTR aggregates in the brain. [...]
2021 - 10.1111/febs.15339
The FEBS Journal, Vol. 288, Num. 1 (January 2021) , p. 310-324  
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2025-12-10
10:02
19 p, 1.1 MB Oral antiviral vaccines in aquaculture : Current status, challenges, and future prospects / Rojas Peña, Mauricio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Aceituno Abarzúa, Patricia (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Ordóñez Grande, Borja (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; García Ordóñez, Marlid (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Liang, Xueru (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Okeleye, Oluwabusayo Israel (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Ji, Jie (Nanjing Normal University) ; Roher Armentia, Nerea (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Vaccination remains the most effective strategy for preventing viral infections in the aquaculture industry. Most commercially available antiviral vaccines are produced from attenuated viral particles and administered via intraperitoneal or intramuscular injection. [...]
2026 - 10.1016/j.fsi.2025.110962
Fish & shellfish immunology, Vol. 168 (January 2026) , art. 110962  
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2025-11-25
04:09
11 p, 741.3 KB Moonlighting Proteins : Some Hypotheses on the Structural Origin of Their Multifunctionality / Cedano Rodríguez, Juan Antonio (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Huerta Casado, Mario (University Hospital Heidelberg. Institute of Pathology) ; Mozo-Villarias, Angel (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Querol Murillo, Enrique (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Moonlighting proteins-single polypeptides performing multiple, often unrelated functions-are increasingly recognized as key players in human disease and microbial pathogenesis, making their identification crucial for understanding disease mechanisms and developing targeted therapies. [...]
2025 - 10.3390/ijms262110375
International journal of molecular sciences, Vol. 26, Num. 21 (November 2025) , art. 10375  
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2025-11-19
06:48
15 p, 2.0 MB Exosome Biomarker Profiling Using a Paper-Based Vertical Flow Assay / Pallarès-Rusiñol, Arnau (Universitat Autònoma de Barcelona. Departament de Química) ; Marfà, Jennifer (Universitat Autònoma de Barcelona. Departament de Química) ; Rossi, Rosanna (Universitat Autònoma de Barcelona. Departament de Química) ; Martí, Mercè (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Pividori, María Isabel (Universitat Autònoma de Barcelona. Departament de Química)
Exosomes are nanoscale extracellular vesicles that carry valuable biomolecular information. However, their characterization still depends on complex and costly techniques such as flow cytometry. In this study, a paper-based Vertical Flow Assay (VFA) specifically designed for the detection and profiling of exosomes derived from metastatic breast cancer cell lines is presented. [...]
2025 - 10.3390/bios15100694
Biosensors, Vol. 15, Issue 10 (October 2025) , art. 694  
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2025-11-11
04:15
19 p, 2.3 MB Predicting Metabolic Syndrome Using Supervised Machine Learning : A Multivariate Parameter Approach / Valdez Vega, Rodolfo (Universidad de Guadalajara (Mèxic)) ; Noboa-Velástegui, Jacqueline Alejandra (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Fletes Rayas, Ana Lilia (Universidad de Guadalajara (Mèxic)) ; Álvarez Pérez, Iñaki (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí") ; Ramos Marquez, Martha Eloisa (Universidad de Guadalajara (Mèxic)) ; Ruíz Quezada, Sandra Luz (Universidad de Guadalajara (Mèxic)) ; Torres Carrillo, Nora Magdalena (Universidad de Guadalajara (Mèxic)) ; Navarro Hernández, Rosa Elena (Universidad de Guadalajara (Mèxic))
Metabolic syndrome (MetS) is a complex condition characterized by a group of interconnected metabolic abnormalities. Due to its increasing prevalence, better predictive markers are needed. Therefore, this study aims to develop predictive models for MetS by integrating adipokines, metabolic and cardiovascular risk factors, and anthropometric indices. [...]
2025 - 10.3390/ijms26209897
International journal of molecular sciences, Vol. 26, Num. 20 (October 2025) , art. 9897  
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