2025-11-29
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704.2 KB |
A randomized clinical trial to evaluate the efficacy of cognitive rehabilitation and music therapy in mild cognitive impairment in Huntington's disease
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Moreu Valls, Andrea (Universitat Autònoma de Barcelona. Departament d'Infermeria) ;
Puig-Davi, Arnau (Institut de Recerca Sant Pau) ;
Martínez-Horta, Saul (Institut de Recerca Sant Pau) ;
Kulisevsky, Gabriel (Institut de Recerca Sant Pau) ;
Sampedro, Frederic (Institut de Recerca Sant Pau) ;
Pérez-Pérez, Jesús (Institut de Recerca Sant Pau) ;
Horta, Andrea (Institut de Recerca Sant Pau) ;
Olmedo-Saura, Gonzalo (Institut de Recerca Sant Pau) ;
Pagonabarraga Mora, Javier (Institut de Recerca Sant Pau) ;
Kulisevsky, Jaime (Universitat Autònoma de Barcelona. Departament de Medicina)
Background: Cognitive impairment is a core feature of Huntington's disease (HD), yet no disease-modifying or symptomatic interventions have demonstrated efficacy in addressing these deficits. Non-pharmacological interventions, particularly cognitive training (CT), are promising options for maintaining neural plasticity, enhancing cognition, and improving emotional well-being. [...]
2025 -  10.1007/s00415-025-12927-2
Journal of neurology, Vol. 272, Num. 3 (February 2025)
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2025-11-25
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2025-11-25
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16 p, 1.2 MB |
Nuevo balón scoring para el tratamiento de lesiones coronarias con calcificación de moderada a grave. Primer estudio en humanos Naviscore
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Serra Peñaranda, A. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya)) ;
Fernández-Peregrina, Estefanía (Institut de Recerca Sant Pau) ;
Jimenez, Marcelo (Institut de Recerca Sant Pau) ;
García del Blanco, Bruno (Hospital Universitari Vall d'Hebron) ;
Romani, S. (Complejo Hospitalario Universitario de Cáceres) ;
Moreiras, J.M. (Hospital Universitario de Salamanca) ;
Bermúdez, E.P. (Hospital Universitario Virgen de la Arrixaca (Múrcia)) ;
Rodrigues, A. (Centro Hospitalar de Vila Nova de Gaia e Espinho) ;
Ojeda, S. (Hospital Universitario Reina Sofía (Córdoba, Espanya)) ;
López, N.G. (Hospital Clínico San Carlos (Madrid)) ;
Regueiro, Ander (Hospital Clínic i Provincial de Barcelona) ;
Frutos, A.S. (Hospital Clínico Universitario de Valladolid) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Introducción y objetivos: Las lesiones coronarias calcificadas son cada vez más prevalentes y suponen un reto terapéutico. Aunque se pueden tratar con distintos dispositivos, los balones de corte (BC) y de scoring (BS) son herramientas potentes y de más fácil uso que otros dispositivos de mayor complejidad. [...]
Introduction and objectives: Calcified coronary lesions are becoming more prevalent and remain therapeutically challenging. Although a variety of devices can be used in this setting, cutting balloons (CB) and scoring balloons (SB) are powerful and simple tools to treat calcified plaques vs more complex devices. [...]
2025 - 10.24875/RECICE.M24000484
REC: Interventional Cardiology, Vol. 7 Núm. 2 (abril 2025) , p. 91-98
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2025-11-25
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13 p, 3.0 MB |
Inter-organ communication : pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop
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Pearce, L. (University College London) ;
Galán-Arriola, C. (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)) ;
Bell, R.M. (University College London) ;
Carr, R.D. (Ulster University) ;
Cunningham, J. (University College London) ;
Davidson, Sean M. (University College London) ;
Ghosh, A.K. (University College London) ;
Giesz, S. (University College London) ;
Golforoush, P. (University College London) ;
Gourine, A.V. (University College London) ;
Hermann, D.M. (University of Duisburg-Essen) ;
Heusch, Gerd (University of Duisburg-Essen) ;
Kalkhoran, S.B. (The Hatter Cardiovascular Institute. University College London) ;
Lecour, Sandrine (University of Cape Town) ;
Lukhna, K. (University of Cape Town) ;
Ntsekhe, M. (University of Cape Town) ;
Sack, M.N. (National Institutes of Health (Bethesda, Estats Units d'Amèrica)) ;
Unwin, R.J. (University College London) ;
Vilahur, Gemma (Institut de Recerca Sant Pau) ;
Walker, J.M. (University College London) ;
Yellon, D.M. (University of Cape Town) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
A long-standing aim in the setting of various pathologies including acute myocardial infarction, chronic kidney disease (CKD), and ischaemic stroke, has been to identify successful approaches to augment cellular and organ protection. [...]
2025 (Ibanez, B.) - 10.1007/s00395-024-01094-6
Basic Research in Cardiology, Vol. 120 Núm. 2 (april 2025) , p. 287-299
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2025-11-25
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12 p, 479.0 KB |
Enhancing health equity considerations in guidelines : health equity extension of the GIN-McMaster Guideline Development Checklist
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Dewidar, Omar (University of Ottawa) ;
Sayfi, S. (McMaster University (Canadà)) ;
Pardo, J.P. (University of Ottawa) ;
Welch, V. (University of Ottawa) ;
Wright, G.C. (Grace C Wright MD PC Inc.) ;
Akl, Elie A. (American University of Beirut) ;
Khabsa, Joanne (American University of Beirut Medical Center) ;
Lin, J.S. (Kaiser Permanente Center for Health Research) ;
Wang, X. (University of Ottawa Heart Institute) ;
Darzi, A.J. (McMaster University (Canadà)) ;
Lotfi, Tamara (McMaster University (Canadà)) ;
Pottie, K. (Western University) ;
Khawandi, J. (University of Kansas Medical Center) ;
Morgan, R.L. (Case Western Reserve University) ;
Pereira Nunes Pinto, Ana Carolina (Institut de Recerca Sant Pau) ;
Tufte, J. (COVID-END Equity group) ;
Brennan, S.E. (Monash University) ;
Motilall, A. (McMaster University (Canadà)) ;
Oloyede, O. (Sefako Makgatho Health Sciences University) ;
Mustafa, R.A. (University of Kansas Health System) ;
Petkovic, J. (University of Ottawa) ;
Nieuwlaat, R. (McMaster University (Canadà)) ;
Xia, J. (University of Nottingham Ningbo) ;
Yao, X. (McMaster University (Canadà)) ;
Chi, Yuan (Beijing Yealth Technology Co.. Ltd) ;
Schünemann, Holger (Humanitas University) ;
Tugwell, P. (Bruyère Health Research Institute) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background: Practice guidelines may reduce health inequities by addressing preventable and unjust differences in health. However, health equity considerations are often inadequately integrated into the guideline planning and development process. [...]
2025 - 10.1016/j.eclinm.2025.103135
EClinicalMedicine, Vol. 82 (april 2025) , p. 103135
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2025-11-25
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15 p, 1.1 MB |
Assessing therapeutic decisions in generalized myasthenia gravis : Study protocol
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Gutiérrez-Gutiérrez, Gerardo (Hospital Universitario Infanta Sofía) ;
Gómez-Ballesteros, R. (Roche Farma) ;
Sotoca Fernández, Javier (Hospital Universitari Vall d'Hebron) ;
Ares, A. (Complejo Asistencial Universitario León) ;
Villaverde, R. (Hospital General Universitario Morales Meseguer (Múrcia)) ;
Reyes, V. (Hospital Regional Universitario de Málaga) ;
Armangué, T. (Hospital Sant Joan de Déu) ;
Salas, Eduardo (Roche Farma) ;
Díaz-Abós, P. (Roche Farma) ;
Rebollo, P. (IQVIA) ;
Sarmiento, M. (IQVIA) ;
Escobar, I. (Roche Farma) ;
Maurino, Jorge (Roche Farma) ;
Querol, Luis (Institut de Recerca Sant Pau) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background The therapeutic landscape in generalized myasthenia gravis (gMG) has been continuously evolving in recent years, with over five products approved, each with different efficacy, safety, and administration profiles. [...]
2025 - 10.1371/journal.pone.0322168
PloS one, Vol. 20 Núm. 4 April (april 2025) , p. e0322168
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2025-11-25
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4 p, 232.9 KB |
Gestionar futuras pandemias en un contexto urbano Un desafío para la salud pública
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Pérez Albarracín, Glòria (Institut de Recerca Sant Pau) ;
Salobral, R. (Agencia de Salut Publica de Barcelona) ;
Simón Vivan, Pere (Institut de Recerca Sant Pau) ;
Artazcoz, Lucía 1963- (Institut de Recerca Sant Pau) ;
Rodríguez-Sanz, Maica (Institut de Recerca Sant Pau) ;
Pasarín, M. Isabel (Institut de Recerca Sant Pau) ;
Borrell i Thió, Carme (Institut de Recerca Sant Pau) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
La pandemia de COVID-19 representó un desafío para el cual muchos países y ciudades no estaban preparados. Las ciudades, debido a sus entornos físicos y sociales, son especialmente vulnerables a los efectos de las crisis de salud. [...]
The COVID-19 pandemic posed a challenge for which many countries and cities were unprepared. Cities, due to their physical and social environments, are particularly vulnerable to the effects of health crises. [...]
2025 - 10.1016/j.gaceta.2025.102469
Gaceta sanitaria, Vol. 39 (enero 2025) , p. 102469
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2025-11-25
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9 p, 255.6 KB |
Negative symptoms and sex differences in first episode schizophrenia : What's their role in the functional outcome? A longitudinal study
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Amoretti, Silvia (University of Perugia) ;
Mezquida, Gisela (Hospital Clínic i Provincial de Barcelona) ;
Verdolini, Norma (Hospital Clínic i Provincial de Barcelona) ;
Bioque, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Sánchez-Torres, A.M. (Complejo Hospitalario de Navarra) ;
Pina-Camacho, Laura (Hospital General Universitario Gregorio Marañón) ;
Zorrilla, Iñaki (Instituto de Salud Carlos III) ;
Trabsa, Amira (Hospital del Mar (Barcelona, Catalunya)) ;
Rodriguez-Jimenez, Roberto (Universidad Complutense de Madrid) ;
Corripio, Iluminada (Institut de Recerca Sant Pau) ;
Sarró, Salvador (FIDMAG Germanes Hospitalàries Research Foundation) ;
Ibañez, A. (Hospital Universitario Ramón y Cajal (Madrid)) ;
Usall, J. (Parc Sanitari Sant Joan de Déu) ;
Segarra, R. (Hospital Universitario de Cruces - Osakidetza) ;
Vieta, Eduard (Hospital Clínic i Provincial de Barcelona) ;
Roberto, Natalia (Hospital Clínic i Provincial de Barcelona) ;
Ramos-Quiroga, Josep Antoni (Hospital Universitari Vall d'Hebron) ;
Tortorella, Alfonso (Hospital Universitari Vall d'Hebron) ;
Menculini, G. (Hospital Universitari Vall d'Hebron) ;
Parellada, M. (Hospital General Universitario Gregorio Marañón) ;
González-Pinto, Ana (Instituto de Salud Carlos III) ;
Berrocoso, E. (Hospital Universitario Puerta del Mar (Cadis, Andalusia)) ;
Bernardo, Miquel (Hospital Clínic i Provincial de Barcelona) ;
Forte, Maria Florencia (Hospital Clínic i Provincial de Barcelona) ;
Serra-Navarro, Maria (Hospital Clínic i Provincial de Barcelona) ;
Alonso-Solís, Anna (Institut de Recerca Sant Pau) ;
Grasa, Eva (Institut de Recerca Sant Pau) ;
Corres, E.G. (Universidad del País Vasco) ;
Fernandez Sevillano, J. (Universidad del País Vasco) ;
Toll Abelló, Agustí (Hospital del Mar (Barcelona, Catalunya)) ;
Martínez Sadurní, Laura (Hospital del Mar (Barcelona, Catalunya)) ;
Nuñez-Doyle, A. (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Sanchez-Pastor, L. (Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)) ;
Pomarol-Clotet, E. (Instituto de Salud Carlos III) ;
Guerrero-Pedraza, A. (Hospital Benito Menni) ;
Butjosa Molines, Anna (Hospital Infanto-juvenil Sant Joan de Déu) ;
Pardo, M. (Hospital Infanto-juvenil Sant Joan de Déu) ;
López-Ilundain, J.M. (Complejo Hospitalario de Navarra) ;
Ribeiro, M. (Complejo Hospitalario de Navarra) ;
Saiz-Ruiz, J. (Universidad de Alcalá) ;
Escarti, M.J. (Fundación Investigación Hospital Clínico de Valencia) ;
Contreras, Fernando (Hospital Universitari de Bellvitge) ;
De-la-Cámara, Concepción (Universidad de Zaragoza) ;
Zabala Rabadán, A. (Instituto de Salud Carlos III) ;
Portilla, M.P. (Centro Médico de Asturias) ;
Cuesta, Manuel J. (Complejo Hospitalario de Navarra) ;
León-Quismondo, Leticia (Hospital Universitario Ramón y Cajal (Madrid)) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Introduction: Negative symptoms (NS) include asociality, avolition, anhedonia, alogia, and blunted affect and are linked to poor prognosis. It has been suggested that they reflect two different factors: diminished expression (EXP) (blunted affect and alogia) and amotivation/pleasure (MAP) (anhedonia, avolition, asociality). [...]
2025 - 10.1016/j.sjpmh.2023.04.001
Spanish journal of psychiatry and mental health, Vol. 18 Núm. 2 (january 2025) , p. 91-99
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2025-11-25
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13 p, 702.5 KB |
Plasma p-tau212 as a biomarker of sporadic and Down syndrome Alzheimer's disease
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Kac, Przemysław R. (University of Gothenburg) ;
Alcolea, Daniel (Institut de Recerca Sant Pau) ;
Montoliu-Gaya, L. (University of Gothenburg) ;
Fernández, S. (Fundació Catalana Síndrome de Down) ;
Rodriguez, J.L. (University of Gothenburg) ;
Maure, L. (Fundació Catalana Síndrome de Down) ;
González-Ortiz, F. (Sahlgrenska University Hospital) ;
Benejam, Bessy (Fundació Catalana Síndrome de Down) ;
Turton, M. (Bioventix Plc) ;
Barroeta, Isabel (Fundació Catalana Síndrome de Down) ;
Harrison, P. (Bioventix Plc) ;
Videla Toro, Laura (Fundació Catalana Síndrome de Down) ;
Ashton, Nicholas J. (King's College London) ;
Lleó, Alberto (Institut de Recerca Sant Pau) ;
Zetterberg, Henrik (UCL Institute of Neurology (Regne Unit)) ;
Carmona Iragui, María (Fundació Catalana Síndrome de Down) ;
Karikari, Thomas K. (University of Pittsburgh) ;
Fortea, Juan (Fundació Catalana Síndrome de Down) ;
Blennow, Kaj (University of Science and Technology of China and First Affiliated Hospital of USTC) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
BACKGROUND: All individuals with Down syndrome (DS) will develop full-blown Alzheimer's disease (AD) pathology by age 40. Several genes encoded in chromosome 21, including dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A), have been proven to contribute to the pathology. [...]
2025 - 10.1002/alz.70172
Alzheimer's & dementia, Vol. 21 Núm. 4 (april 2025) , p. e70172
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2025-11-25
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11 p, 1.3 MB |
The Effect of Staging Intervals on Progression-Free Survival in Registration Studies of Oncologic Drugs : A Meta-Analysis
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Zuellig, J.A. (University of Basel) ;
Adam, Roman (University of Basel) ;
Udry, F. (University of Basel) ;
Tibau Martorell, Ariadna (Institut de Recerca Sant Pau) ;
Šeruga, B. (Univerza V Ljubljani) ;
Ocaña, A. (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos) ;
Amir, Eitan (University of Toronto) ;
Templeton, A.J. (St. Clara Research) ;
Universitat Autònoma de Barcelona.
Departament de Medicina
Background/Objectives: To study whether shorter restaging intervals are associated with lower hazard ratios (HRs) for progression-free survival (PFS), as suggested in breast cancer. Methods: Studies supporting the registration of oncologic drugs in Switzerland from 2010 to 2022 were analyzed. [...]
2025 - 10.3390/cancers17081359
Cancers, Vol. 17 Núm. 8 (april 2025) , p. 1359
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