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Institut de Neurociències (INc)

En el año 2003 un grupo de biólogos moleculares, fisiólogos, neuropatólogos, histólogos, psicólogos, psicobiólogos y bioinformáticos que trabajan en la UAB creamos el INc con el objetivo estratégico de dejar atrás las disciplinas tradicionales, y abordar de manera multidisciplinaria y translacional cuestiones claves del cerebro en el siglo XXI como son la neurodegeneración, la neuroregeneración y las bases de la mente normal o trastornada. Nos interesa cómo funciona el cerebro normal, qué ocurre cuando enferma, y cómo se cura. Exploramos todos los niveles de la organización biológica desde la interacción de moléculas al comportamiento usando para ello cultivos celulares, modelos animales y pacientes. Nuestro objetivo final es desarrollar nuevas terapias celulares, moleculares, genéticas para el tratamiento de patologías cerebrales.

 
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2026-05-29
16:13
15 p, 870.7 KB Streamlined Quantification of Microglial Morphology in Mouse Brains Using 3D Immunofluorescence Analysis / Donato, Maria Helena de (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kouchaeknejad, Armin (Universitat Autònoma de Barcelona. Institut de Neurociències) ; de Donato, Andreu (Universitat de Barcelona) ; Walt, Gunter van der (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Puighermanal Puigvert, Emma (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia
Microglial cells are crucial patrolling immune cells in the brain and pivotal contributors to neuroinflammation during pathogenic or degenerative stress. Microglia exhibit a heterogeneous "dendrite-like" dense morphology that is subject to change depending on inflammatory status. [...]
2025 - 10.21769/BioProtoc.5218
Bio-protocol, Vol. 15, Num. 4 (February 2025) , art. e5218  
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2026-05-06
12:10
17 p, 11.0 MB Identification of Subtype-Selective Binding Sites in the Opioid Receptor Family / Severo Gomes, Antoniel Augusto (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Guillot, Benoît (Université de Lorraine) ; Jelsch, Christian (Université de Lorraine) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Selectivity is essential in drug discovery for finding or developing more effective opioid modulators. Structure-based approaches and binding kinetics effectively identify potential druggable regions and determine ligand candidates for improved therapies. [...]
2026 - 10.1021/acs.jcim.5c02403
Journal of chemical information and modeling, Vol. 66, Num. 8 (27 2026) , p. 4717-4733  
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2026-05-05
15:12
22 p, 1.3 MB Mesenchymal Stromal/Stem Cells in Chronic Incomplete Traumatic Spinal Cord Injury : A Phase I/II Double-Blind Placebo-Controlled Multicentre Trial / Martins Braga, Fernando (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Kumru, Hatice (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Benito-Penalva, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Vives Armengol, Joaquim (Universitat Autònoma de Barcelona. Departament de Medicina) ; Coll-Bonet, Ruth (Universitat Autònoma de Barcelona. Banc de Sang i Teixits) ; Ge, Wanbao (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rodríguez Gómez, Luciano (Universitat Autònoma de Barcelona. Banc de Sang i Teixits) ; Codinach, Margarita (Universitat Autònoma de Barcelona. Banc de Sang i Teixits) ; Iglesia López, Aurora de la (Complejo Hospitalario Universitario de A Coruña) ; Gómez Rodríguez, Antonio (Complejo Hospitalario Universitario de A Coruña) ; Cid-Fernández, José Javier (Complejo Hospitalario Universitario de A Coruña) ; Montoto-Marqués, Antonio (Complejo Hospitalario Universitario de A Coruña) ; Vidal, Joan (Universitat Autònoma de Barcelona. Institut de Neurociències)
Background/Objectives: Chronic traumatic spinal cord injury (SCI) causes persistent neurological deficits for which no clinically effective regenerative therapy is currently available. Mesenchymal stromal/stem cells (MSCs), particularly Wharton's jelly-derived MSCs (WJ-MSCs), demonstrate immunomodulatory and neurotrophic potential. [...]
2026 - 10.3390/biomedicines14040762
Biomedicines, Vol. 14, Num. 4 (April 2026) , p. 762  
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2026-04-22
10:12
26 p, 1.9 MB Peripheral Oxidation-Inflammation and Immunosenescence in Triple-Transgenic Mice for Alzheimer's Disease (3xTg-AD) at Early Neuropathological Stages of Disease and Decrease of Immune Impairment by Voluntary Exercise / Fuente, Monica de la (Universidad Complutense de Madrid) ; Garrido, Antonio (Universidad Europea de Madrid) ; Vida, Carmen (Universidad Complutense de Madrid) ; Manassra, Rashed (Universidad Complutense de Madrid) ; Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Universitat Autònoma de Barcelona. Institut de Neurociències
Inflammatory-oxidative stress generated by immune cells plays an important role in aging and in age-related neurodegenerative disorders such as Alzheimer's disease (AD). Triple-transgenic mice for AD (3xTg-AD) are a suitable model for mimicking this disease in an age-dependent manner. [...]
2026 - 10.3390/biom16030475
Biomolecules, Vol. 16, Num. 3 (March 2026) , p. 475  
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2026-04-27
15:12
24 p, 5.9 MB Understanding cell-penetrating peptide mechanisms using computational electrophysiology simulations / Catalina-Hernández, Èric (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) ; Aguilella-Arzo, Marcel (Universitat Jaume I) ; López-Martín, Mario (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Cell-penetrating peptides (CPPs) can enter cells without inducing cytotoxicity and can be coupled with cargo molecules to be used to deliver drugs, DNA, or nanoparticles into cells. The peptide-membrane interactions driving the internalization mechanism are not completely understood. [...]
2026 - 10.1002/pro.70536
Protein science, Vol. 35, Num. 4 (April 2026) , art. e70536  
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2026-04-10
10:12
28 p, 1.3 MB Premature Neuroimmune and Redox-Inflammatory Breakdown at the Prodromal Stage in Male and Female Triple-Transgenic Alzheimer's Disease Mice / Gimenez-Llort, Lydia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Vida, Carmen (Universidad Complutense de Madrid) ; Félix, Judith (Universidad Complutense de Madrid. Departamento de Genética, Fisiología y Microbiología) ; Quer-Palomas, Silvia (Universitat Autònoma de Barcelona. Departament de Psiquiatria i de Medicina Legal) ; Fuente, Monica de la (Hospital Universitario 12 de Octubre (Madrid)) ; Manassra, Rashed (Universidad Complutense de Madrid)
Background/Objectives: Homeostatic (nervous, immune and endocrine) systems and their communications network are crucial for health and aging rate. We previously reported behavioral and peritoneal leukocyte function alterations and oxidative-inflammatory stress in young female triple-transgenic (3xTg) mice for Alzheimer's disease (AD). [...]
2026 - 10.3390/diseases14020061
Diseases, Vol. 14, Num. 2 (February 2026) , p. 61  
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2026-04-10
10:12
28 p, 1.3 MB The possibilities of conscious experience in light of the dual origin hypothesis of the neocortex / Chanes, Lorena (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut) ; García-Cabezas, Miguel Ángel (Universidad Autónoma de Madrid)
According to contemporary psycho- and physiological perspectives, the brain supports our experience of the world by constantly anticipating what may happen next. In this context, limbic mesocortical areas have been proposed to play a key domain-general role in cortical processing, holding highly abstract content that may be efficiently broadcasted to virtually the whole brain, ultimately integrating interoception into a unified field of experience from the point of view of someone who has a body. [...]
2026 - 10.1093/nc/niaf058
Neuroscience of Consciousness, Vol. 2025 (January 2026) , art. niaf058  
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2026-04-10
13:12
24 p, 1.0 MB Brentuximab-Induced Peripheral Neurotoxicity : A Multidisciplinary Approach to Manage an Emerging Challenge in Hodgkin Lymphoma Therapy / Velasco, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Domingo-Domenech, Eva (Universitat de Barcelona) ; Sureda, Anna (Universitat de Barcelona)
This article highlights the importance of monitoring peripheral neurotoxicity in patients with Hodgkin lymphoma (HL) who receive brentuximab vedotin, with a particular focus on early recognition and multidisciplinary management of this type of toxicity. [...]
2021 - 10.3390/cancers13236125
Cancers, Vol. 13 (December 2021) , art. 6125  
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2026-03-13
12:12
13 p, 6.8 MB Treatment with slow-releasing hydrogen sulfide donors inhibits the nociceptive and depressive-like behaviours accompanying chronic neuropathic pain : Endogenous antioxidant system activation / Cabarga, Laura (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Batallé Melgarejo, Gerard (Institut de Recerca Sant Pau) ; Pol, Olga (Institut de Recerca Sant Pau)
Background: Therapies to treat chronic neuropathic pain and its associated comorbidities are limited. Recent studies demonstrated that the administration of slow-releasing hydrogen sulfide (HS) donors inhibited chemotherapy-induced neuropathic pain. [...]
2020 - 10.1177/0269881120913154
Journal of Psychopharmacology, Vol. 34, Num. 7 (January 2020) , p. 737-749  
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2026-04-15
14:12
19 p, 2.5 MB Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer's disease / Riberas Sánchez, Andrea (Universitat de Girona) ; García-Brito, Soleil (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Vila Solés, Laia (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ; Aldavert Vera, Laura (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de les Ciències de la Salut) ; Segura Torres, Pilar (Universitat Autònoma de Barcelona, Bellaterra. Institut de Neurociències) ; Huguet, Gemma (Universitat de Girona) ; Carreras-Badosa, Gemma (Universitat de Girona) ; Kádár, Elisabet (Universitat de Girona)
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease associated with aging. While deep brain stimulation (DBS) shows therapeutic promise, the long-term persistence of its effects remains understudied. [...]
2025 - 10.3389/fnagi.2025.1671196
Frontiers in aging neuroscience, Vol. 17 (November 2025) , art. 1671196  
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