HIV and mature dendritic cells : Trojan exosomes riding the Trojan horse?
Izquierdo Useros, Nuria (IrsiCaixa Foundation)
Naranjo-Gómez, Mar (Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol)
Erkizia, Itziar (IrsiCaixa Foundation)
Puertas, María Carmen (IrsiCaixa Foundation)
Borràs Serres, Francesc Enric (Fundació Institut per a la Investigació en Ciències de la Salut Germans Trias i Pujol)
Blanco, Julià (IrsiCaixa Foundation)
Martínez Picado, Francisco Javier (Institució Catalana de Recerca i Estudis Avançats)

Date: 2010
Abstract: Exosomes are secreted cellular vesicles that can induce specific CD4+ T cell responses in vivo when they interact with competent antigen-presenting cells like mature dendritic cells (mDCs). The Trojan exosome hypothesis proposes that retroviruses can take advantage of the cell-encoded intercellular vesicle traffic and exosome exchange pathway, moving between cells in the absence of fusion events in search of adequate target cells. Here, we discuss recent data supporting this hypothesis, which further explains how DCs can capture and internalize retroviruses like HIV-1 in the absence of fusion events, leading to the productive infection of interacting CD4+ T cells and contributing to viral spread through a mechanism known as trans-infection. We suggest that HIV-1 can exploit an exosome antigen-dissemination pathway intrinsic to mDCs, allowing viral internalization and final trans-infection of CD4+ T cells. In contrast to previous reports that focus on the ability of immature DCs to capture HIV in the mucosa, this review emphasizes the outstanding role that mature DCs could have promoting trans-infection in the lymph node, underscoring a new potential viral dissemination pathway.
Rights: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Language: Anglès
Document: article ; publishedVersion
Subject: HIV ; Antigen-presenting cells ; HIV-1 ; Immune response
Published in: PLoS pathogens, Vol. 6, Issue 3 (March 2010) , p. e1000740, ISSN 1553-7374

PMID: 20360840

9 p, 5.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (scientific output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Published articles

 Record created 2013-10-14, last modified 2020-11-23

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