Per citar aquest document: https://ddd.uab.cat/record/113378
Scopus: 21 cites, Web of Science: 20 cites,
A selective sweep of >8 Mb on chromosome 26 in the Boxer genome
Quilez Oliete, Javier (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Short, Andrea D. (Centre for Integrated Genomic Medical Research (Manchester, Regne Unit))
Martínez Díaz, Verónica (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Kennedy, Lorna J. (Centre for Integrated Genomic Medical Research (Manchester, Regne Unit))
Ollier, William (Centre for Integrated Genomic Medical Research (Manchester, Regne Unit))
Sánchez Bonastre, Armando (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Altet Sanahujes, Laura (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)
Francino Martí, Olga (Universitat Autònoma de Barcelona. Departament de Ciència Animal i dels Aliments)

Data: 2011
Resum: Background: Modern dog breeds display traits that are either breed-specific or shared by a few breeds as a result of genetic bottlenecks during the breed creation process and artificial selection for breed standards. Selective sweeps in the genome result from strong selection and can be detected as a reduction or elimination of polymorphism in a given region of the genome. Results: Extended regions of homozygosity, indicative of selective sweeps, were identified in a genome-wide scan dataset of 25 Boxers from the United Kingdom genotyped at ~20,000 single-nucleotide polymorphisms (SNPs). These regions were further examined in a second dataset of Boxers collected from a different geographical location and genotyped using higher density SNP arrays (~170,000 SNPs). A selective sweep previously associated with canine brachycephaly was detected on chromosome 1. A novel selective sweep of over 8 Mb was observed on chromosome 26 in Boxer and for a shorter region in English and French bulldogs. It was absent in 171 samples from eight other dog breeds and 7 Iberian wolf samples. A region of extended increased heterozygosity on chromosome 9 overlapped with a previously reported copy number variant (CNV) which was polymorphic in multiple dog breeds. Conclusion: A selective sweep of more than 8 Mb on chromosome 26 was identified in the Boxer genome. This sweep is likely caused by strong artificial selection for a trait of interest and could have inadvertently led to undesired health implications for this breed. Furthermore, we provide supporting evidence for two previously described regions: a selective sweep on chromosome 1 associated with canine brachycephaly and a CNV on chromosome 9 polymorphic in multiple dog breeds.
Drets: Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. Creative Commons
Llengua: Anglès
Document: article ; publishedVersion
Publicat a: BMC Genomics, Vol. 12, N. 339 (July 2011) , p. 1-12, ISSN 1471-2164

DOI: 10.1186/1471-2164-12-339
PMID: 21722374


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